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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
856 questions in 87 reviews · Cystic Fibrosis and Genetic Disorders
current versionsNo studies 856 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Hypertonic saline 7% vs hypertonic saline 3% FEV1 (% predicted) change from baseline, long‐term · children with cystic fibrosis Nebulised hypertonic saline for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Hypertonic saline 7% vs hypertonic saline 3% LCI · children with cystic fibrosis Nebulised hypertonic saline for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Hypertonic saline 7% vs hypertonic saline 3% Mortality · children with cystic fibrosis Nebulised hypertonic saline for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Hypertonic saline 7% vs hypertonic saline 3% Measures of sputum clearance · children with cystic fibrosis Nebulised hypertonic saline for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Hypertonic saline 7% vs hypertonic saline 3% Pulmonary exacerbations · children with cystic fibrosis Nebulised hypertonic saline for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Hypertonic saline 7% vs hypertonic saline 3% Adverse events · children with cystic fibrosis Nebulised hypertonic saline for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Hypertonic saline 3% to 7% vs isotonic saline FEV1 (% predicted) change from baseline, long‐term · adults and children with cystic fibrosis (during acute exacerbations of lung disease) Nebulised hypertonic saline for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Bisphosphonates vs placebo BMD: % change in BMD at the hip or femur · children with cystic fibrosis who have not had a lung transplant Bisphosphonates for osteoporosis in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Bisphosphonates vs placebo QoL · children with cystic fibrosis who have not had a lung transplant Bisphosphonates for osteoporosis in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Bisphosphonates vs no bisphosphonates QoL · adults with cystic fibrosis who have had a lung transplant Bisphosphonates for osteoporosis in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs extrapulmonary mechanical percussion Mucus weight · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs ACBT Respiratory exacerbations: time to first exacerbation · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs ACBT QoL: change in CFQ score · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs ACBT Mucus weight · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs O‐PEP devices Respiratory exacerbations: number of respiratory exacerbations per year · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs AD Respiratory exacerbations: number of respiratory exacerbations per year · children and adolescents with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs AD QoL · children and adolescents with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs AD Mucus weight · children and adolescents with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs exercise FEV1 · children and young adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs exercise FVC · children and young adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs exercise FEF25–75 · children and young adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs exercise Respiratory exacerbations: number of respiratory exacerbations per year · children and young adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs PEP Respiratory exacerbations: number of respiratory exacerbations per year · children and adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs exercise QoL · children and young adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs exercise Adherence to therapy and individual preference · children and young adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
CCPT vs exercise Mucus weight · children and young adults with cystic fibrosis Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Cycled inhaled tobramycin (TNS) vs culture‐based TNS Eradication of P aeruginosa from the respiratory tract: proportion of participants with one or more isolates of P aeruginosa from the respiratory tract · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Cycled inhaled tobramycin (TNS) vs culture‐based TNS FVC · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Ciprofloxacin vs placebo added to cycled and culture‐based inhaled tobramycin (TNS) therapy Eradication of P aeruginosa from the respiratory tract: proportion of participants with one or more isolates of P aeruginosa from the respiratory tract · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Ciprofloxacin vs placebo added to cycled and culture‐based inhaled tobramycin (TNS) therapy FVC · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Oral ciprofloxacin and inhaled colistin vs inhaled tobramycin (TNS) FVC · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Oral ciprofloxacin and inhaled colistin vs inhaled tobramycin (TNS) Isolation of other micro‐organisms from the respiratory tract: number of positive cultures per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Inhaled colistin plus oral ciprofloxacin vs inhaled tobramycin (TNS) plus oral ciprofloxacin FEV1: relative change in % predicted FEV1 from baseline · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Inhaled colistin plus oral ciprofloxacin vs inhaled tobramycin (TNS) plus oral ciprofloxacin FVC · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Inhaled colistin plus oral ciprofloxacin vs inhaled tobramycin (TNS) plus oral ciprofloxacin Growth and nutritional status · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Inhaled tobramycin (TNS) vs placebo Growth and nutritional status: change in weight (kg) from baseline · adults and children with cystic fibrosis and a positive microbiological isolate of Pseudomonas aeruginosa from a… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Inhaled colistin plus oral ciprofloxacin vs inhaled tobramycin (TNS) plus oral ciprofloxacin Frequency of infective pulmonary exacerbations: number of exacerbations per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Inhaled tobramycin (TNS) vs placebo Frequency of infective pulmonary exacerbations: number of exacerbations per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of Pseudomonas aeruginosa from a… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Oral ciprofloxacin and inhaled colistin vs no treatment Eradication of P aeruginosa from the respiratory tract · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Oral ciprofloxacin and inhaled colistin vs no treatment FEV1 · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Oral ciprofloxacin and inhaled colistin vs no treatment FVC · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Oral ciprofloxacin and inhaled colistin vs no treatment Growth and nutritional status · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Oral ciprofloxacin and inhaled colistin vs no treatment Frequency of infective pulmonary exacerbations: number of exacerbations per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Oral ciprofloxacin and inhaled colistin vs no treatment Isolation of other micro‐organisms from the respiratory tract: number of positive cultures per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
14 days inhaled AZLI plus 14 days placebo vs 28 days inhaled AZLI FEV1 % predicted · children and adolescents with cystic fibrosis Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
14 days inhaled AZLI plus 14 days placebo vs 28 days inhaled AZLI FVC % predicted · children and adolescents with cystic fibrosis Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
Inhaled tobramycin (TNS) vs placebo Isolation of other micro‐organisms from the respiratory tract: number of positive cultures per patient year · adults and children with cystic fibrosis and a positive microbiological isolate of Pseudomonas aeruginosa from a… Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
14 days inhaled AZLI plus 14 days placebo vs 28 days inhaled AZLI Growth and nutritional status · children and adolescents with cystic fibrosis Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
14 days inhaled AZLI plus 14 days placebo vs 28 days inhaled AZLI Frequency of infective pulmonary exacerbations · children and adolescents with cystic fibrosis Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |
14 days inhaled AZLI plus 14 days placebo vs 28 days inhaled AZLI Isolation of other micro‐organisms from the respiratory tract · children and adolescents with cystic fibrosis Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane | no estimate extracted | NR | No studies |