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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
856 questions in 87 reviews · Cystic Fibrosis and Genetic Disorders
current versionsNo studies 856 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Isoxsuprine vs placebo Quality of life ‐ not reported · individuals with sickle cell disease and a leg ulcer Interventions for treating leg ulcers in people with sickle cell disease (2021) · Cochrane | no estimate extracted | NR | No studies |
Isoxsuprine vs placebo Amputation ‐ not reported · individuals with sickle cell disease and a leg ulcer Interventions for treating leg ulcers in people with sickle cell disease (2021) · Cochrane | no estimate extracted | NR | No studies |
Isoxsuprine vs placebo Adverse events ‐ not reported · individuals with sickle cell disease and a leg ulcer Interventions for treating leg ulcers in people with sickle cell disease (2021) · Cochrane | no estimate extracted | NR | No studies |
Arginine butyrate plus standard care alone vs standard care alone Time to ulcer closure ‐ not reported · individuals with sickle cell disease and a leg ulcer Interventions for treating leg ulcers in people with sickle cell disease (2021) · Cochrane | no estimate extracted | NR | No studies |
High‐dose rhGH vs standard‐dose rhGH QoL · children and young adults with CF Recombinant growth hormone therapy for cystic fibrosis in children and young adults (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs spontaneous cough Participant preference · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs spontaneous cough Exercise tolerance · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs spontaneous cough Number of admissions to hospital · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs spontaneous cough Need for extra treatment · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs active cycle of breathing technique Number of admissions to hospital · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs positive expiratory pressure Exercise tolerance: modified shuttle test · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs positive expiratory pressure Adverse events · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs positive expiratory pressure Number of admissions to hospital · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs Cornet® Exercise tolerance: modified shuttle test · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs Cornet® Adverse events · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs Cornet® Number of admissions to hospital · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs Flutter® Exercise tolerance: modified shuttle test · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs conventional physiotherapy Exercise tolerance · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs Flutter® Adverse events · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs Flutter® Number of admissions to hospital · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs high frequency chest wall oscillation FEV1 · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs high frequency chest wall oscillation QoL · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs high frequency chest wall oscillation Participant preference · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs high frequency chest wall oscillation Exercise tolerance (modified shuttle test) · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs high frequency chest wall oscillation Adverse events · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs high frequency chest wall oscillation Number of admissions to hospital · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs high frequency chest wall oscillation Need for extra treatment · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs conventional physiotherapy Adverse events · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs intrapulmonary percussive ventilation (200 bpm) QoL · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs intrapulmonary percussive ventilation (200 bpm) Participant preference · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs intrapulmonary percussive ventilation (200 bpm) Exercise tolerance (modified shuttle test) · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs intrapulmonary percussive ventilation (200 bpm) Adverse events · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs intrapulmonary percussive ventilation (200 bpm) Number of admissions to hospital · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs intrapulmonary percussive ventilation (200 bpm) Need for extra treatment · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs intrapulmonary percussive ventilation (400 bpm) QoL · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs intrapulmonary percussive ventilation (400 bpm) Participant preference · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs intrapulmonary percussive ventilation (400 bpm) Exercise tolerance (modified shuttle test) · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs intrapulmonary percussive ventilation (400 bpm) Adverse events · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs intrapulmonary percussive ventilation (400 bpm) Number of admissions to hospital · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs intrapulmonary percussive ventilation (400 bpm) Need for extra treatment · adults with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Autogenic drainage vs spontaneous cough QoL · adults and children with CF Autogenic drainage for airway clearance in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Cardiac function  · children and adults with mucopolysaccharidosis type VI Enzyme replacement therapy with galsulfase for mucopolysaccharidosis type VI (2021) · Cochrane | no estimate extracted | NR | No studies |
Cisapride vs placebo Hospitalisation for any cause · people with cystic fibrosis Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Cisapride vs placebo Hospitalisation for DIOS · people with cystic fibrosis Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Cisapride vs placebo Quality of life · people with cystic fibrosis Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Cisapride vs placebo Tolerability · people with cystic fibrosis Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ high‐dose pancreatic enzymes vs low‐dose pancreatic enzymes Time taken from start of treatment until the resolution of DIOS · children and adults with cystic fibrosis Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ high‐dose pancreatic enzymes vs low‐dose pancreatic enzymes Treatment failure rate · children and adults with cystic fibrosis Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ high‐dose pancreatic enzymes vs low‐dose pancreatic enzymes Adherence · children and adults with cystic fibrosis Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis (2021) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics Acquisition of multiply‐resistant S aureus · children with cystic fibrosis Prophylactic anti‐staphylococcal antibiotics for cystic fibrosis (2020) · Cochrane | no estimate extracted | NR | No studies |