What do systematic reviews say?

Withdrawal due to serious adverse events Not reported · patients with rheumatoid arthritis

Adverse events: serious adverse events ‐ not reported · patients with schizophrenia

Adverse event** Less patient involvement as a result of the intervention Not measured · older patients with multi‐morbidity

Serious adverse events ‐ Haemodilution versus control. · patients with liver resection.

Adverse events None of the included studies evaluated adverse events · young people (aged 10 to 18 years old) with harmful sexual behaviour

Adverse events None of the included studies evaluated adverse events · young people (aged 10 to 18 years old) with harmful sexual behaviour

Adverse events ‐ total participants with adverse events · patients (mainly young male adults) with fractures of the middle third of the clavicle

Number of women reporting adverse events ‐ not reported · women with urinary incontinence

Number of women reporting adverse events ‐ not reported · women with urinary incontinence

Number of women reporting adverse events ‐ not reported · women with urinary incontinence

Number of women reporting adverse events ‐ not reported · women with urinary incontinence

Adverse events considered non‐serious · participants with unresectable hepatocellular carcinoma

Dropouts due to adverse events · adults (aged 18 and older) exposed to a traumatic event

Dropouts due to adverse events · adults (aged 18 and older) exposed to a traumatic event

Dropouts due to adverse events · adults (aged 18 and older) exposed to a traumatic event

Severe adverse events leading to withdrawal of treatment · bacterial folliculitis and boils (furuncles and carbuncles)

Severe adverse events leading to withdrawal of treatment · bacterial folliculitis and boils (furuncles and carbuncles)

Severe adverse events leading to withdrawal of treatment · bacterial folliculitis and boils (furuncles and carbuncles)

Withdrawals due to adverse events not measured · atopic eczema

Serious adverse events: life‐threatening/ hospitalisation · adults with surgical wounds