What do systematic reviews say?

Grades 3 and 4 adverse events ‐ not reported · individuals with moderate to severe disease

Grades 3 and 4 adverse events ‐ not reported · outpatients withmild disease

Grades 3 and 4 adverse events · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Adverse events (seroma or allergic reaction) · adults with pilonidal sinus

Withdrawals due to adverse events · active EoE pediatric patients

Any adverse events (excluding major bleeding) · people with cerebral small vessel disease and no dementia

Number of participants experiencing any serious adverse events · Children with obstructive sleep apnoea (aged 15 years or younger)

Serious adverse events: cardiovascular events · Dialysis vascular access outcomes in AVF patients with ESKD

Adverse events: new diagnosis of heart failure · Human trial participants undergoing ablation for atrial fibrillation

Adverse events: new diagnosis of heart failure · Human trial participants undergoing ablation for atrial fibrillation

Adverse events: new diagnosis of heart failure · Human trial participants undergoing ablation for atrial fibrillation

Adverse events resulting from DUS surveillance · people who underwent a lower limb revascularisation

Adverse events resulting from DUS surveillance · people who underwent a lower limb revascularisation

Number of participants experiencing any serious adverse events · Children with obstructive sleep apnoea (aged 15 years or younger)

Adverse events ‐ Gastrointestinal disturbances · women with subfertility

Discontinuation of medication due to adverse events · Women of reproductive age seeking to avoid pregnancy

Serious adverse events at 'less than 3 months' · patients with suspected or diagnosed myocardial infarction

Number of participants reporting an adverse event · patients with hip osteoarthritis

Number of participants reporting an adverse event · patients with hip osteoarthritis

Number of participants reporting an adverse event · patients with hip osteoarthritis