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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
41 questions in 3 reviews · cluster CL0338
current versionsNo studies 0 · 0%Ungraded 33 · 80.5%Very low 0 · 0%Low 7 · 17.1%Moderate 1 · 2.4%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Age 8-10 years vs Age >10 years Spontaneous space closure · Children and adolescents with maxillary permanent first molar extraction · Follow-up to complete eruption of the permanent second molar, Maxilla Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR >100.00 [0.01, >100.00] | 3 studies | Ungraded |
Mandibular third molar present vs Mandibular third molar absent Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR 2.28 [1.67, 3.09] | 4 studies · 467 participants | Low |
Extraction of the permanent first molar vs None (single-group prevalence) Spontaneous space closure · Children and adolescents (<18 years) after extraction of a permanent first molar before eruption of the permanent… · Until eruption of the permanent second molar (median follow-up 4.0 years), Maxilla Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | Prevalence 85.3 [73.7, 92.3] | 9 studies · 665 participants | Ungraded |
Extraction of a maxillary permanent first molar vs Extraction of a mandibular permanent first molar Spontaneous space closure · Children and adolescents (<18 years) after extraction of a permanent first molar before eruption of the permanent… · Until eruption of the permanent second molar (median follow-up 4.0 years), Overall Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR 7.77 [4.99, 12.11] | 9 studies · 1349 participants | Low |
Not applicable (single-group prevalence) vs Not applicable (single-group prevalence) Regular toothbrushing usage (prevalence) · Children (<18 years) with intellectual and developmental disabilities (IDD) in India · Overall Oral health status of children with intellectual and developmental disabilities in India: a systematic… (2024) | Prevalence 91 [80, 96] | 6 studies · 1036 participants | Ungraded |
Extraction at patient age 11-12 years vs Extraction at patient age 8-10 years Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR 0.82 [0.35, 1.88] | 2 studies | Ungraded |
Extraction at patient age 11-12 years vs Extraction at patient age 8-10 years Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR 0.29 [0.11, 0.81] | 2 studies | Ungraded |
Second molar at Nolla developmental stage 6-7 at extraction vs Second molar at later Nolla stages at extraction Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR 55.1 [3.0, at least 100.0] | 1 study | Ungraded |
Extraction of the permanent first molar vs None (single-group prevalence) Spontaneous space closure · Children and adolescents (<18 years) after extraction of a permanent first molar before eruption of the permanent… · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | Prevalence 48.1 [34.5, 62.0] | 11 studies · 1095 participants | Ungraded |
Higher mean patient age (per 1 year) vs Lower mean patient age (per 1-year decrement) Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR 0.59 [0.20, >100.00] | 3 studies | Ungraded |
Second molar distally inclined at extraction vs Second molar upright at extraction Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR 1.18 [0.43, 3.21] | 3 studies | Ungraded |
Unilateral extraction of the mandibular first permanent molar vs Bilateral extraction of the mandibular first permanent molars Midline deviation of the mandibular arch · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR 11.6 [1.9, 70.3] | 1 study | Ungraded |
Second molar at Demirjian stage F-G at extraction vs Second molar at Demirjian stage D-E at extraction Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR 0.68 [0.28, 1.66] | 4 studies | Ungraded |
Second molar at Demirjian stage A-D at extraction vs Second molar at Demirjian stage G-H at extraction Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR 2.75 [0.50, 15.10] | 3 studies | Ungraded |
Extraction of the mandibular permanent first molar vs None (single-group prevalence) Rotation of the mandibular second premolar · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | Prevalence 60.0 [10.7, 95.0] | 2 studies · 105 participants | Ungraded |
Male sex vs Female sex Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR 1.38 [0.37, 5.14] | 2 studies | Ungraded |
Second molar at Demirjian stage E at extraction vs Second molar at Demirjian stage F-H at extraction Spontaneous space closure · Children and adolescents after extraction of a maxillary permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Maxilla Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR 4.78 [1.56, 14.66] | 3 studies · 252 participants | Low |
M2 Demirjian stages F-G vs M2 Demirjian stages E-D Spontaneous space closure · Children and adolescents with maxillary permanent first molar extraction · Follow-up to complete eruption of the permanent second molar, Maxilla Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR >100.00 [0.01, >100.00] | 3 studies | Ungraded |
Second molar at Demirjian stage E-F at extraction vs Second molar at Demirjian stage G-H at extraction Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR 4.44 [0.43, 46.10] | 3 studies | Ungraded |
Second molar at Demirjian stage A-D at extraction vs Second molar at Demirjian stage F-H at extraction Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR 3.11 [1.25, 7.72] | 3 studies · 95 participants | Low |
Second molar mesially inclined at extraction vs Second molar upright at extraction Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR 0.68 [0.27, 1.71] | 3 studies | Ungraded |
Not applicable (single-group prevalence) vs Not applicable (single-group prevalence) Poor (inadequate) oral hygiene (prevalence) · Children (<18 years) with intellectual and developmental disabilities (IDD) in India · Overall Oral health status of children with intellectual and developmental disabilities in India: a systematic… (2024) | Prevalence 38 [21, 59] | 5 studies · 1333 participants | Ungraded |
Extraction at patient age <8 years vs Extraction at patient age >10 years Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR 5.01 [1.45, 17.30] | 2 studies · 15 participants | Low |
Extraction at patient age 8-10 years vs Extraction at patient age >10 years Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR 3.32 [1.73, 6.36] | 3 studies · 109 participants | Low |
Extraction of the mandibular permanent first molar vs None (single-group prevalence) Rotation of the mandibular second permanent molar · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | Prevalence 76.9 [15.5, 98.4] | 2 studies · 108 participants | Ungraded |
Second molar at Demirjian stage E at extraction vs Second molar at Demirjian stage F-H at extraction Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR 3.81 [1.85, 7.83] | 3 studies · 94 participants | Low |
Dental crowding present vs Dental spacing present Spontaneous space closure · Children and adolescents (<18 years) after extraction of a permanent first molar before eruption of the permanent… · Until eruption of the permanent second molar (median follow-up 4.0 years), Overall Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR 5.9 [1.3, 27.7] | 1 study | Ungraded |
Extraction of the permanent first molar vs None (single-group prevalence) Spontaneous space closure · Children and adolescents (<18 years) after extraction of a permanent first molar before eruption of the permanent… · Until eruption of the permanent second molar (median follow-up 4.0 years), Overall (both jaws) Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | Prevalence 61.6 [50.2, 71.9] | 13 studies · 1787 participants | Ungraded |
Extraction of the mandibular permanent first molar vs None (single-group prevalence) Rotation of the mandibular first premolar · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar) · Until eruption of the permanent second molar (median follow-up 4.0 years), Mandible Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | Prevalence 37.8 [0.7, 98.2] | 2 studies · 109 participants | Ungraded |
M2 Demirjian stages A-D vs M2 Demirjian stages F-H Spontaneous space closure · Children and adolescents with maxillary permanent first molar extraction · Follow-up to complete eruption of the permanent second molar, Maxilla Spontaneous space closure after extraction of permanent first molars in children and adolescents: a… (2024) | OR >100.00 [0.02, >100.00] | 3 studies | Ungraded |
Mutans streptococci present in oral samples at baseline vs Mutans streptococci absent in oral samples at baseline Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline) · 6 months to 3.5 years, Overall Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and… (2023) | OR 4.13 [3.33, 5.12] | 12 studies · 3010 participants | Moderate |
Mutans streptococci present in oral samples at baseline vs Mutans streptococci absent in oral samples at baseline Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline) · 6 months to 3.5 years, Sample: plaque Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and… (2023) | OR 5.16 [2.99, 8.91] | 5 studies · 736 participants | Ungraded |
Mutans streptococci present in oral samples at baseline vs Mutans streptococci absent in oral samples at baseline Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline) · 6 months to 3.5 years, Sample: saliva Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and… (2023) | OR 3.92 [3.20, 4.80] | 9 studies · 2577 participants | Ungraded |
Mutans streptococci present in oral samples at baseline vs Mutans streptococci absent in oral samples at baseline Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline) · 1 year, Follow-up: 1 year Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and… (2023) | OR 4.37 [3.50, 5.45] | 4 studies · 2016 participants | Ungraded |
Mutans streptococci present in oral samples at baseline vs Mutans streptococci absent in oral samples at baseline Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline) · 2.7 years (31 months median), Follow-up: 2.7 years (31 months median) Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and… (2023) | OR 33.00 [3.18, 342.26] | 1 study · 28 participants | Ungraded |
Mutans streptococci present in oral samples at baseline vs Mutans streptococci absent in oral samples at baseline Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline) · 2 years, Follow-up: 2 years Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and… (2023) | OR 2.53 [1.22, 5.23] | 4 studies · 297 participants | Ungraded |
Mutans streptococci present in oral samples at baseline vs Mutans streptococci absent in oral samples at baseline Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline) · 6 months to 3.5 years, Microbiological assessment: quantitative (culture/CFU counting) Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and… (2023) | OR 3.82 [2.01, 7.26] | 6 studies · 732 participants | Ungraded |
Mutans streptococci present in oral samples at baseline vs Mutans streptococci absent in oral samples at baseline Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline) · 3.5 years (42 months), Follow-up: 3.5 years (42 months) Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and… (2023) | OR 4.23 [2.49, 7.18] | 1 study · 366 participants | Ungraded |
Mutans streptococci present in oral samples at baseline vs Mutans streptococci absent in oral samples at baseline Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline) · 6 months, Follow-up: 6 months Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and… (2023) | OR 4.65 [2.01, 10.76] | 2 studies · 303 participants | Ungraded |
Mutans streptococci present in oral samples at baseline vs Mutans streptococci absent in oral samples at baseline Development of any (cavitated or non-cavitated) carious lesion · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline) · 6 months to 3.5 years, Microbiological assessment: semi-quantitative (Dentocult/commercial kit) Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and… (2023) | OR 4.36 [3.53, 5.39] | 6 studies · 2278 participants | Ungraded |
Mutans streptococci detected in plaque or saliva at baseline vs No mutans streptococci detected in plaque or saliva at baseline Development of carious lesions · Children younger than 6 years with caries-free primary dentition · 6 months to 3.5 years, Overall sample sensitivity analysis Is Mutans Streptococci count a risk predictor of Early Childhood Caries? A systematic review and… (2023) | OR 4.04 [3.33, 4.90] | 12 studies · 3313 participants | Ungraded |