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Evidence found and GRADE certainty

3,032 questions · 3,358 findings · 190 reviews · Oral Health · related questions CL0289

No studies found 599 · 17.8%GRADE not reported 1,759 · 52.4%Very low 612 · 18.2%Low 269 · 8%Moderate 107 · 3.2%High 12 · 0.4%

Cryotherapy (ice chips) 30 minutes vs Cryotherapy (ice chips) 60 minutes

Oral mucositis (any severity) · Adults with solid cancers receiving fluorouracil (5FU) and leucovorin

It is very uncertain whether oral cryotherapy for 30 minutes changes oral mucositis (any severity) compared with oral cryotherapy for 60 minutes (very low certainty).

1 finding from 1 review

Maxillary sinus lift (augmentation) with long implants vs Short implants (5 to 8.5 mm) without sinus augmentation

Patient satisfaction · Patients with missing teeth and an atrophic posterior maxilla, with residual bone height between 4 and 9 mm below the maxillary sinus
1 finding from 1 review

IMZ TPS titanium cylinders vs ITI TPS solid titanium screws

Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

IMZ TPS titanium cylinders showed no clear difference in implant failure compared with ITI TPS solid titanium screws; GRADE not reported.

1 finding from 1 review

Branemark Mark II turned titanium screws vs ITI TPS solid titanium screws

Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

Branemark Mark II turned titanium screws showed no clear difference in implant failure compared with ITI TPS solid titanium screws; GRADE not reported.

1 finding from 1 review

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Mandibular ramus growth · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
1 finding from 1 review

Powered toothbrush, side-to-side action vs Manual toothbrush

Plaque · Individuals of any age with no reported disability that might affect toothbrushing (including people wearing orthodontic appliances)

Powered toothbrush, side-to-side action showed no clear difference in plaque score (>3 months) compared with manual toothbrush; GRADE not reported.

2 findings from 1 review

Bio-Oss (anorganic bovine bone) vs A different bone substitute

Implant failure · Patients undergoing two-stage maxillary sinus augmentation

Bone substitute (anorganic bovine bone / Bio-Oss) showed no clear difference in implant failure compared with A different bone substitute; GRADE not reported.

1 finding from 1 review

Powered toothbrush, ionic action vs Manual toothbrush

Plaque · Individuals of any age with no reported disability that might affect toothbrushing (including people wearing orthodontic appliances)

Powered toothbrush, ionic action led to lower plaque score (1 to 3 months) compared with manual toothbrush; GRADE not reported.

2 findings from 1 review

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Stability of anterior open bite correction (1 year after treatment) · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…

The review found no eligible studies for this question.

1 finding from 1 review

Resorbable barrier (membrane) to seal the lateral window vs No membrane to seal the lateral window

Implant failure · Patients undergoing lateral-window maxillary sinus lift

Resorbable barrier (membrane) to seal the lateral window showed no clear difference in implant failure compared with no membrane to seal the lateral window; GRADE not reported.

1 finding from 1 review

Sucralfate suspension (topical) vs Placebo suspension

Duration of episodes · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care

Sucralfate suspension (topical) showed no clear difference in mean duration of episodes compared with placebo suspension; GRADE not reported.

1 finding from 1 review

One-stage lateral sinus lift with monocortical autogenous bone blocks (iliac crest) vs Two-stage lateral sinus lift with autogenous particulate bone (iliac crest)

Complication (perforation of sinus membrane) at augmented site · Patients with 2 to 7 mm of residual alveolar bone height in the edentulous maxillary sinus floor

One-stage lateral sinus lift with monocortical autogenous bone… showed no clear difference in complications (sinus membrane perforation) compared with two-stage lateral sinus lift with autogenous particulate bone (iliac…; GRADE not reported.

1 finding from 1 review

Early loading of mini-screw implant vs Delayed loading of mini-screw implant

Success of the anchorage device · Patients undergoing orthodontic treatment requiring surgical (mini-screw implant) anchorage

Early loading of mini-screw implant showed no clear difference in success of the anchorage device compared with delayed loading of mini-screw implant; GRADE not reported.

1 finding from 1 review

Interferon-alpha (topical lozenges) vs placebo

Total ulcer burden · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • Kilic 2009 (interferon-alpha lozenges 1000 IU or 2000 IU vs placebo, 84 patients; high risk of selective reporting): the data presented did not allow analysis; authors reported no statistically significant difference…
    1 study · 84 participants
    GRADE not reported

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

Reduction or treatment of obstructive sleep apnoea syndrome (OSAS) or upper airway resistance syndrome (UARS) · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…

The review found no eligible studies for this question.

1 finding from 1 review

IMZ TPS titanium cylinders vs ITI TPS hollow titanium screws

Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

IMZ TPS titanium cylinders showed no clear difference in implant failure compared with ITI TPS hollow titanium screws; GRADE not reported.

1 finding from 1 review

Systemic interventions (aciclovir, thalidomide, corticosteroids, rebamipide, etanercept, colchicine, interferon-alpha) vs placebo

Episode duration associated with oral ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • SoF 2 (systemic interventions vs placebo), grouped comment spanning all four listed outcomes (verbatim; the review's wording "topical" is a typo for systemic): "8 placebo-controlled trials evaluated topical…
    Studies not reported
    GRADE not reported

Removable appliance with palatal crib associated with high-pull chincup vs no treatment

Mandibular ramus growth · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
1 finding from 1 review
  • Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomes
    End of treatment (12 months)
    Cephalometric data (SNA, Co-A, SNB, Ar-Go, Ar.GoMe, Co-Gn, ANB) were reported to be not significantly different between groups; effects were dento-alveolar rather than skeletal. No pooled estimate (Almeida 2005).
    1 study
    GRADE not reported