Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,032 questions · 3,358 findings · 190 reviews · related questions CL0289

No studies found 599 · 17.8%GRADE not reported 1,759 · 52.4%Very low 612 · 18.2%Low 269 · 8%Moderate 107 · 3.2%High 12 · 0.4%

Brain wave music (BWM) vs No special instructions (control)

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adults undergoing orthodontic treatment

Brain wave music (BWM) showed no clear difference in patient‐reported pain intensity or pain relief (VAS, NRS or… compared with no special instructions (control); GRADE not reported.

3 findings from 1 review

Physical barriers (tongue protector) vs placebo

Change in QoL - anxiety (surrogate marker) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether physical barriers (tongue protector) changes change in QoL - anxiety (surrogate marker) compared with placebo (very low certainty).

1 finding from 1 review

Perioperative infraorbital nerve block vs Intravenous analgesia

Need for analgesic prescription for pain (supplemental analgesic requirements) · Children up to 13 years of age, undergoing cleft lip repair surgery

It is very uncertain whether perioperative infraorbital nerve block changes need for analgesic prescription for pain (supplemental analgesic… compared with intravenous analgesia (very low certainty).

1 finding from 1 review

Any experimental intervention (surgical or non-surgical) vs active control

Healing of osteonecrosis - improvement ('healed' or 'improved' vs 'unchanged' or 'worse') · People of any age and either sex, in any setting, with BRONJ; bisphosphonate exposure past or current; includes people with cancer and…

The review found no eligible studies for this question.

1 finding from 1 review

Perioperative infraorbital nerve block vs Placebo (sham/placebo device)

Heart rate, respiratory rate, and blood pressure · Children up to 13 years of age, undergoing cleft lip repair surgery
1 finding from 1 review

Oral appliance or functional orthopaedic appliance vs placebo or no treatment

Daytime symptom: sleepiness (Brouillette questionnaire) · Children with obstructive sleep apnoea (aged 15 years or younger)

It is very uncertain whether oral appliance or functional orthopaedic appliance changes daytime symptom: sleepiness (Brouillette questionnaire) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Cholinergics (bethanechol 15 mg/day) vs placebo

Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether cholinergics (bethanechol 15 mg/day) changes relief of burning/discomfort (symptom relief; pain intensity) compared with placebo (very low certainty).

1 finding from 1 review

Psychological therapies (cognitive therapy) vs placebo

Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether psychological therapies (cognitive therapy) changes relief of burning/discomfort (symptom relief; pain intensity) compared with placebo (very low certainty).

1 finding from 1 review

Topical treatments (capsaicin oral rinse) vs placebo

Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
2 findings from 1 review
  • Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
    short-term (up to 3 months) · capsaicin oral rinse
    Capsaicin oral rinse (Marino 2010; Silvestre 2012) contributes to the topical treatments short-term symptom-relief comparison (insufficient/contradictory). Silvestre 2012 data not presented due to 23% first-phase…
    1 study
    GRADE not reported
  • Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
    long-term (>3 to 6 months) · capsaicin oral rinse
    MD -2.60 [-5.11, -0.09]
    1 study · 18 participants
    Very low

Chemically cured zinc phosphate cement vs Glass ionomer cement (GIC)

Decalcification · Patients with full arch fixed orthodontic appliances with bands attached to molars (patients with cleft lip/palate or other craniofacial…
1 finding from 1 review
  • Adhesives for fixed orthodontic bands 2016 · Cochrane All outcomes
    Approximately 12 months (to end of treatment)
    No statistical analysis. Kvam 1983 (28 participants): 4 teeth affected by small decalcification spots (reversed by polishing and fluoride), all with the zinc phosphate cement. Galarraga 2003 (40 participants): 8…
    2 studies · 68 participants
    GRADE not reported

Guided tissue regeneration (GTR) with bovine bone mineral + resorbable collagen membrane vs No GTR (no grafting)

Healing - 1 year · People requiring retreatment of periapical lesions (failed root canal therapy)

Guided tissue regeneration (GTR) with bovine bone mineral +… showed no clear difference in healing - 1 year compared with no GTR (no grafting) (low certainty).

1 finding from 1 review

Oral appliance or functional orthopaedic appliance vs placebo or no treatment

Irritability · Children with obstructive sleep apnoea (aged 15 years or younger)

It is very uncertain whether oral appliance or functional orthopaedic appliance changes daytime symptom: irritability (Brouillette questionnaire) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Systemic beta carotene or carotenoids (incl. lycopene) vs placebo or no treatment

Malignant transformation (oral cancer development) · People with a diagnosis of oral leukoplakia

It is very uncertain whether systemic beta carotene or carotenoids (incl. lycopene) changes oral cancer development compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Perioperative infraorbital nerve block vs Placebo (sham/placebo device)

Duration of postoperative analgesia · Children up to 13 years of age, undergoing cleft lip repair surgery

It is very uncertain whether perioperative infraorbital nerve block changes duration of postoperative analgesia (in hours) compared with placebo (sham block) (very low certainty).

1 finding from 1 review

Monitoring (any means of observation, supervision, keeping under review, measuring or testing at intervals) vs No monitoring

Leaving the study early · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

Monitoring (any means of observation, supervision, keeping under… showed no clear difference in leaving the study early compared with no monitoring (moderate certainty).

1 finding from 1 review