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Evidence found and GRADE certainty

397 questions · 449 findings · 37 reviews · Dental caries · related questions CL0289

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No studies found 39 · 8.7%GRADE not reported 245 · 54.6%Very low 72 · 16%Low 42 · 9.4%Moderate 51 · 11.4%High 0 · 0%

Induction chemotherapy plus locoregional treatment (radiotherapy and/or surgery) vs Locoregional treatment (radiotherapy and/or surgery) alone

Overall survival, induction cisplatin + 5-fluorouracil prior to concurrent chemoradiation (cisplatin) vs concurrent chemoradiation (cisplatin) · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Induction chemotherapy plus locoregional treatment (radiotherapy… showed no clear difference in overall survival, induction cisplatin + 5-fluorouracil prior to… compared with locoregional treatment (radiotherapy and/or surgery) alone (low certainty).

1 finding from 1 review

Chemotherapy regimen A (+/- locoregional treatment) vs Chemotherapy regimen B (+/- locoregional treatment)

Locoregional control · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
1 finding from 1 review

Rubber dam isolation and moisture control (alone or with saliva aspiration) vs Cotton rolls (with or without saliva aspiration)

Clinical evaluation of restoration's quality · Dental patients undergoing direct or indirect restorative treatment (no age or gender restriction)
1 finding from 1 review
  • Rubber dam isolation for restorative treatment in dental patients 2021 · Cochrane All outcomes
    6, 12, 18 months · Non-carious cervical lesions (composite restoration)
    Loguercio 2015: no significant differences (P>0.05) in marginal staining and marginal adaptation of NCCL restorations between rubber dam and cotton rolls/retraction cords at 6, 12 and 18 months.
    1 study · 30 participants
    GRADE not reported

Clear aligners (Invisalign / thermoformed aligners) vs Fixed appliances

Lesion area (decalcification area, pixels) · Adults undergoing orthodontic treatment

A single study reported a larger decalcification lesion area with aligners versus fixed appliances in adults at 3 months (MD 80.50 pixels, 95% CI 60.52 to 100.48; ungraded).

1 finding from 1 review

Rubber dam isolation and moisture control (alone or with saliva aspiration) vs Cotton rolls (with or without saliva aspiration)

Participant acceptance/satisfaction · Dental patients undergoing direct or indirect restorative treatment (no age or gender restriction)
1 finding from 1 review
  • Rubber dam isolation for restorative treatment in dental patients 2021 · Cochrane All outcomes
    Non-carious cervical lesions (composite restoration)
    Evidence did not support higher acceptance/preference for rubber dam than cotton rolls (P = 0.85 from binomial test on 28 participants; very low-certainty evidence) (Loguercio 2015).
    1 study · 28 participants
    Very low

Concomitant (concurrent) chemoradiotherapy vs Radiotherapy alone

Overall survival, adjuvant concomitant chemoradiotherapy vs post-surgery radiotherapy alone · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Concomitant (concurrent) chemoradiotherapy probably leads to lower overall survival, concurrent chemoradiotherapy vs radiotherapy alone… compared with radiotherapy alone (non-resectable tumours) (moderate certainty).

1 finding from 1 review

No additional acid etching (self-etch adhesive alone) after Er,Cr:YSGG preparation vs Prior acid etching before self-etch adhesive after Er,Cr:YSGG preparation

Incidence of microleakage · Er,Cr:YSGG laser-prepared cavities restored with self-etch adhesive systems (in vitro)

At the dentin margin, prior acid etching with self-etch adhesives significantly reduced microleakage (RR 2.44, 95% CI 1.38-4.34; ungraded).

3 findings from 1 review

Traditional bur cavity preparation vs Er,Cr:YSGG laser cavity preparation

Incidence of microleakage · Human teeth requiring cavity preparation and restoration (in vitro)

At the dentin margin, microleakage did not differ significantly between bur and Er,Cr:YSGG laser preparation (RR 1.26, 95% CI 0.67-2.38; ungraded).

4 findings from 1 review
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No additional acid etching (etch-and-rinse adhesive alone) after Er,Cr:YSGG preparation vs Prior acid etching before etch-and-rinse adhesive after Er,Cr:YSGG preparation

Incidence of microleakage · Er,Cr:YSGG laser-prepared cavities restored with etch-and-rinse adhesive systems (in vitro)

Prior acid etching with etch-and-rinse adhesives did not significantly change microleakage after Er,Cr:YSGG preparation (RR 1.18, 95% CI 0.63-2.22; ungraded).

1 finding from 1 review

Tooth bleaching (combined in-office and home bleaching) vs No bleaching (untreated control)

Patient satisfaction (measured by patient satisfaction or aesthetic scales) · Patients with post-orthodontic white spot lesions and permanent dentition

In the single RCT, all bleached patients were satisfied with the aesthetic outcome, though the trial was at high risk of bias (ungraded).

1 finding from 1 review

Bleaching vs No bleaching or alternative control

Colour disparity between carious and non-affected enamel · Permanent teeth with post-orthodontic or artificial white spot lesions

Bleaching may diminish colour disparities between carious and non-affected areas (very low certainty).

1 finding from 1 review

Triple antibiotic paste (TAP) vs Abscess remedy (AR)

Overall success (composite of clinical and radiographic success) · Immature (young) permanent teeth with open apex and vital pulp exposed to dental caries or trauma, in children aged 6-14 years

A single RCT found higher pulpotomy success with triple antibiotic paste than abscess remedy (100% vs 80%; statistically significant, P<0.05; not pooled; ungraded).

1 finding from 1 review

Professionally-applied 12,300 ppm F APF foam, every 2 months vs 0 ppm F placebo foam

Number of participants with more severe DLs (severity of DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

The review found no eligible studies for this question.

1 finding from 1 review

Professionally-applied 12,300 ppm F APF foam, every 2 months vs 0 ppm F placebo foam

Number of participants with new demineralised lesions (DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

Professionally-applied 12,300 ppm F APF foam, every 2 months may leads to lower number of participants with new demineralised lesions (DLs) compared with 0 ppm F placebo foam (low certainty).

1 finding from 1 review

Glutaraldehyde + zinc oxide and eugenol (ZOE) vs Full strength formocresol (FC)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Glutaraldehyde + zinc oxide and eugenol (ZOE) showed no clear difference in clinical failure compared with full strength formocresol (FC); GRADE not reported.

1 finding from 1 review

Bilateral extraction of compromised mandibular first permanent molars vs Age- and gender-matched non-extraction controls

Lower incisor inclination (lingual tipping and retrusion) · Children (approximately 11 years or older) with compromised mandibular first permanent molars

Bilateral lower first permanent molar extraction was associated with lingual tipping and retrusion of the lower incisors in one case-control study; ungraded.

1 finding from 1 review

Mineral trioxide aggregate (MTA) vs Calcium hydroxide (CH)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Mineral trioxide aggregate (MTA) may leads to lower radiological failure compared with calcium hydroxide (CH) (low certainty).

2 findings from 1 review