Discomfort/pain · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)
1 finding from 1 review
Locoregional control · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
Amifostine (intravenous) showed no clear difference in locoregional tumour control compared with amifostine (subcutaneous); GRADE not reported.
1 finding from 1 review
HR 1.34 [0.76, 2.36]
1 study
GRADE not reported
Survival · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
The review found no eligible studies for this question.
1 finding from 1 review
Aesthetics: canine rated as abnormal position in the dental arch · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)
Open surgical exposure showed no clear difference in aesthetics: canine rated as abnormal position in the dental arch compared with closed surgical exposure; GRADE not reported.
1 finding from 1 review
Dry mouth (xerostomia) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
Pilocarpine led to lower xerostomia (objective, LENT-SOMA scale) compared with no treatment/placebo; GRADE not reported.
3 findings from 1 review
MD -0.40 [-0.69, -0.11]
1 study · 39 participants
GRADE not reported
RR 1.00 [0.92, 1.08]
2 studies · 48 participants
GRADE not reported
SMD -0.35 [-1.04, 0.33]
2 studies · 126 participants
Very low
Taste acuity improvement - objective outcome (continuous) - individual taste sensations · Patients with taste disturbances (dysgeusia/hypogeusia; idiopathic, zinc-deficient, or secondary to chronic renal failure)
Zinc supplements (zinc sulphate, zinc gluconate, zinc picolinate,… showed no clear difference in taste acuity improvement - objective outcome (continuous) -… compared with placebo; GRADE not reported.
1 finding from 1 review
Interventions for managing taste disturbances 2017 · Cochrane All outcomesChronic renal failure
Results (Mahajan 1980, chronic renal failure; Analysis 1.3): mean difference by taste sensation - salt MD 285 (95% CI 238.75 to 331.25); sweet MD 190 (142.36 to 237.64); sour MD 10 (-16.43 to 36.43); bitter MD 2.40…
1 study · 22 participants
GRADE not reported
Failure to complete orthodontic treatment due to pain · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
The review found no eligible studies for this question.
1 finding from 1 review
Time off school or work · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
The review found no eligible studies for this question.
1 finding from 1 review
Analgesic medication used (type, dose, frequency) · Adults (>16 years old) undergoing orthognathic surgery
The review found no eligible studies for this question.
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
NSAID (systemic) showed no clear difference in pain intensity (VAS 0-100 mm) compared with paracetamol (low certainty).
3 findings from 1 review
MD -5.17 [-11.71, 1.37]
7 studies · 664 participants
Low
MD -0.51 [-8.93, 7.92]
9 studies · 734 participants
Low
MD -2.92 [-8.48, 2.65]
7 studies · 664 participants
Low
Xerostomia (grade >= 2, 0-4 scale) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
Amifostine may leads to lower xerostomia (grade >= 2, 0-4 scale) compared with no treatment/placebo (low certainty).
3 findings from 1 review
RR 0.35 [0.19, 0.67]
3 studies · 119 participants
Low
RR 0.70 [0.40, 1.23]
7 studies · 682 participants
Low
RR 0.66 [0.48, 0.92]
5 studies · 687 participants
Low
Rescue analgesia · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
1 finding from 1 review
Taste disturbance (severe, > 2 on 0-3 scale) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
Polaprezinc led to lower taste disturbance (severe, > 2 on 0-3 scale) compared with azulene oral rinse; GRADE not reported.
1 finding from 1 review
Abutment failure · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown
It is very uncertain whether metal-free implant abutments (zirconia) changes abutment failure compared with metal implant abutments (titanium) (very low certainty).
1 finding from 1 review
Decalcification · Participants with full arch fixed orthodontic appliance(s) with molar tubes bonded to first or second permanent molars; excludes prior…
Bonded molar tubes (attached with adhesive) led to higher decalcification (participant level) compared with molar bands (cemented, e.g. with glass ionomer cement); GRADE not reported.
1 finding from 1 review
Xerostomia (VAS) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review
Oral mucositis (any severity) · Adults with cancer receiving treatment
Granulocyte-colony stimulating factor (G-CSF) led to lower oral mucositis (any severity) compared with placebo or no treatment; GRADE not reported.
2 findings from 1 review
Dry mouth (xerostomia) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
Antimicrobial lozenge showed no clear difference in xerostomia compared with placebo; GRADE not reported.
1 finding from 1 review
Patient response: total discomfort score (pain, difficulty eating, brushing, speaking, bad taste) · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)
Open surgical exposure showed no clear difference in patient response: total discomfort score (pain, difficulty eating,… compared with closed surgical exposure; GRADE not reported.
1 finding from 1 review
Survival · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
The review found no eligible studies for this question.
1 finding from 1 review