Cantilevered bridge failure · Adults (18 years or older) needing replacement of one premolar or incisor with a cantilevered fixed dental prosthesis
1 finding from 1 review
Oral mucositis (moderate to severe) · Adults with cancer receiving treatment
Epidermal growth factor (EGF), oral spray showed no clear difference in oral mucositis (moderate to severe) compared with placebo; GRADE not reported.
2 findings from 1 review
Oral mucositis (any severity) · Children with acute lymphoblastic leukaemia receiving chemotherapy alone
Keratinocyte growth factor (KGF), intravenous led to lower oral mucositis (any severity) compared with chlorhexidine mouthwash; GRADE not reported.
1 finding from 1 review
Dysgeusia (grade >= 2, 0-4 scale) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
Amifostine led to lower dysgeusia (grade >= 2, 0-4 scale) compared with no treatment/placebo; GRADE not reported.
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
It is very uncertain whether ibuprofen taken pre-emptively (about 1 hour before treatment) changes pain intensity (VAS 0-100 mm) compared with ibuprofen taken post-treatment (very low certainty).
3 findings from 1 review
MD -9.74 [-47.88, 28.40]
2 studies · 69 participants
Very low
MD -11.30 [-16.27, -6.33]
1 study · 41 participants
Very low
MD -8.43 [-30.37, 13.50]
2 studies · 69 participants
Very low
Zinc supplements vs Acupuncture
Outcome not reported · Patients with taste disturbances (dysgeusia/hypogeusia; idiopathic, zinc-deficient, or secondary to chronic renal failure)
The review found no eligible studies for this question.
1 finding from 1 review
Mean birth weight · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination
1 finding from 1 review
Patient satisfaction (VAS 0 to 10) · Adults (>16 years old) undergoing orthognathic surgery
It is very uncertain whether resorbable (bioresorbable) plates or screws for fixation changes patient satisfaction (VAS 0 to 10) compared with titanium plates or screws for fixation (very low certainty).
1 finding from 1 review
Normalcy of diet (total parenteral nutrition) · Children receiving bone marrow/stem cell transplantation after conditioning therapy for mixed cancers
Granulocyte-colony stimulating factor (G-CSF; pegfilgrastim, single… showed no clear difference in normalcy of diet (total parenteral nutrition) compared with granulocyte-colony stimulating factor (G-CSF; filgrastim, multiple…; GRADE not reported.
1 finding from 1 review
Rescue analgesia · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
It is very uncertain whether NSAID (systemic) changes rescue analgesia compared with paracetamol (very low certainty).
1 finding from 1 review
Dry mouth (xerostomia) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review
Overall survival · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
Palifermin showed no clear difference in overall survival compared with placebo (moderate certainty).
1 finding from 1 review
HR 1.00 [0.72, 1.39]
3 studies
Moderate
Gestational age (preterm birth < 37 weeks) · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination
It is very uncertain whether periodontal treatment (scaling and root planing, alone or with… changes gestational age (preterm birth < 37 weeks) compared with alternative (less intensive) periodontal treatment, alone or with… (very low certainty).
3 findings from 1 review
Pre‐eclampsia · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination
The review found no eligible studies for this question.
1 finding from 1 review
Oral mucositis (severe) · Adults with cancer receiving treatment
Granulocyte-colony stimulating factor (G-CSF) may leads to lower oral mucositis (severe) compared with placebo or no treatment (low certainty).
1 finding from 1 review
Pain intensity (0‐10cm visual analogue scale) · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)
Open surgical exposure showed no clear difference in patient response: pain/soreness score (visual analogue scale 1 to 10) compared with closed surgical exposure; GRADE not reported.
1 finding from 1 review
Aesthetics · Adults (18 years or older) needing a three-unit tooth-supported fixed dental prosthesis
1 finding from 1 review
Treatment time: time from surgical exposure to eruption/bonding a bracket · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)
Open surgical exposure led to lower treatment time: time from surgical exposure to eruption/bonding a… compared with closed surgical exposure; GRADE not reported.
1 finding from 1 review
Survival (overall survival and locoregional control) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review
Postoperative pain during the immediate recovery period (VAS 0 to 10) · Adults (>16 years old) undergoing orthognathic surgery
It is very uncertain whether resorbable (bioresorbable) plates or screws for fixation changes postoperative pain during the immediate recovery period (VAS 0 to 10) compared with titanium plates or screws for fixation (very low certainty).
1 finding from 1 review