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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Every word you type has to appear somewhere in the question, and the closest matches are ranked first.
3,358 questions in 190 reviews · cluster CL0289
current versionsNo studies 599 · 17.8%Ungraded 1,759 · 52.4%Very low 612 · 18.2%Low 269 · 8%Moderate 107 · 3.2%High 12 · 0.4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Guided tissue regeneration (GTR) combined with bone substitutes/graft vs Open flap debridement (access flap surgery) Change in probing depth (probing depth reduction) · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved… · >=12 months Guided tissue regeneration for periodontal infra-bony defects (2006) · Cochrane | MD 1.24 [0.89, 1.59] | 2 studies | Ungraded |
Lingualised teeth (maxillary anatomic + mandibular non-anatomic; lingualised occlusion scheme) vs Zero-degree teeth (non-anatomic, cuspless) Number of denture adjustments required · Edentulous adult patients requiring complete dentures · 3 weeks per denture set (cross-over) Interventions for replacing missing teeth: denture chewing surface designs in edentulous people (2005) · Cochrane | No statistically significant difference was found between the two occlusal patterns with regard to the number of adjustments required. | 1 study · 30 participants | Ungraded |
Lingualised teeth (maxillary anatomic + mandibular non-anatomic; lingualised occlusion scheme) vs Zero-degree teeth (non-anatomic, cuspless) Patient perceived comfort · Edentulous adult patients requiring complete dentures Interventions for replacing missing teeth: denture chewing surface designs in edentulous people (2005) · Cochrane | no estimate extracted | NR | No studies |
Lingualised teeth (maxillary anatomic + mandibular non-anatomic; lingualised occlusion scheme) vs Zero-degree teeth (non-anatomic, cuspless) Patient perceived masticatory/chewing efficiency · Edentulous adult patients requiring complete dentures Interventions for replacing missing teeth: denture chewing surface designs in edentulous people (2005) · Cochrane | no estimate extracted | NR | No studies |
Lingualised teeth (maxillary anatomic + mandibular non-anatomic; lingualised occlusion scheme) vs Zero-degree teeth (non-anatomic, cuspless) Patient perceived satisfaction (denture preference) · Edentulous adult patients requiring complete dentures · 3 weeks per denture set (cross-over) Interventions for replacing missing teeth: denture chewing surface designs in edentulous people (2005) · Cochrane | OR 10 [2.04, 48.96] | 1 study · 30 participants | Ungraded |
Lingualised teeth (maxillary anatomic + mandibular non-anatomic; lingualised occlusion scheme) vs Zero-degree teeth (non-anatomic, cuspless) Patient perceived masticatory/chewing function · Edentulous adult patients requiring complete dentures Interventions for replacing missing teeth: denture chewing surface designs in edentulous people (2005) · Cochrane | no estimate extracted | NR | No studies |
Stabilisation splint (SS) vs Minimal/no treatment Pain (severity/palpation; PSS, PPI, VAS) · Patients with pain dysfunction syndrome (PDS) of all degrees of severity · 3 months or less Stabilisation splint therapy for temporomandibular pain dysfunction syndrome (2004) · Cochrane | MD -3.20 [-4.81, -1.59] | 4 studies | Ungraded |
Stabilisation splint (SS) vs Jaw exercises TMJ clicking · Patients with pain dysfunction syndrome (PDS) of all degrees of severity · up to 6 months Stabilisation splint therapy for temporomandibular pain dysfunction syndrome (2004) · Cochrane | SS vs jaw exercises (Magnusson 1999): TMJ clicking at 3 months and greater than 3 months; no statistically significant between-group difference. Forest-plot data presented, totals not pooled. | 1 study | Ungraded |
Stabilisation splint (SS) vs Visual feedback Movement (lateral mandibular movement) · Patients with pain dysfunction syndrome (PDS) of all degrees of severity · 3 months or less Stabilisation splint therapy for temporomandibular pain dysfunction syndrome (2004) · Cochrane | SS vs visual feedback (Monteiro 1988): both SS and visual feedback groups showed a significant decrease in lateral mandibular movement scores (P<0.01); data were unavailable for analysis. | 1 study | Ungraded |
Stabilisation splint (SS) vs Bite plates Helkimo dysfunction score · Patients with pain dysfunction syndrome (PDS) of all degrees of severity · 3 months or less Stabilisation splint therapy for temporomandibular pain dysfunction syndrome (2004) · Cochrane | RR 0.68 [0.20, 2.23] | 1 study | Ungraded |
Stabilisation splint (SS) vs Acupuncture Movement (deviation and range of mouth opening) · Patients with pain dysfunction syndrome (PDS) of all degrees of severity · 3 months or less Stabilisation splint therapy for temporomandibular pain dysfunction syndrome (2004) · Cochrane | RR 0.55 [0.35, 0.84] | 1 study | Ungraded |
Direct resin composite veneer vs Indirect resin composite veneer Pain following treatment · Patients with permanent anterior teeth with intrinsic staining suitable for laminate veneer restorations Direct versus indirect veneer restorations for intrinsic dental stains (2004) · Cochrane | Planned outcome; pain following treatment was not reported by the included trial (earlier trial publications reported treatment times, not pain). | 0 studies | No studies |
Stabilisation splint (SS) vs Minimal/no treatment Depression (CES-D, POMS) · Patients with pain dysfunction syndrome (PDS) of all degrees of severity · 3 months or less Stabilisation splint therapy for temporomandibular pain dysfunction syndrome (2004) · Cochrane | MD -3.90 [-6.29, -1.52] | 1 study | Ungraded |
Stabilisation splint (SS) vs Acupuncture Helkimo clinical dysfunction score · Patients with pain dysfunction syndrome (PDS) of all degrees of severity · 3 months or less Stabilisation splint therapy for temporomandibular pain dysfunction syndrome (2004) · Cochrane | SS vs acupuncture (Johansson 1991): Helkimo clinical dysfunction score decreased significantly in both groups (P<0.01) with no significant between-group difference; data not available for a pooled estimate. | 1 study | Ungraded |
Stabilisation splint (SS) vs Acupuncture TMJ clicking · Patients with pain dysfunction syndrome (PDS) of all degrees of severity · 3 months or less Stabilisation splint therapy for temporomandibular pain dysfunction syndrome (2004) · Cochrane | RR 1.00 [0.56, 1.78] | 1 study | Ungraded |
Direct resin composite veneer vs Indirect resin composite veneer Patient satisfaction · Patients with permanent anterior teeth with intrinsic staining suitable for laminate veneer restorations · 2 years Direct versus indirect veneer restorations for intrinsic dental stains (2004) · Cochrane | Meijering 1998 (Table 4): patients satisfied at 2 years - direct resin composite 67%, indirect resin composite 82%. No statistical comparison performed. | 1 study | Ungraded |
Direct resin composite veneer vs Porcelain (indirect) veneer Patient satisfaction · Patients with permanent anterior teeth with intrinsic staining suitable for laminate veneer restorations · 2 years Direct versus indirect veneer restorations for intrinsic dental stains (2004) · Cochrane | Meijering 1998 (Table 4): patients satisfied at 2 years - direct resin composite 67%, porcelain 93%. No statistical comparison performed. | 1 study | Ungraded |
Stabilisation splint (SS) vs Biofeedback/stress management Treatment credibility · Patients with pain dysfunction syndrome (PDS) of all degrees of severity · 3 months or less Stabilisation splint therapy for temporomandibular pain dysfunction syndrome (2004) · Cochrane | MD -0.10 [-0.69, 0.49] | 1 study | Ungraded |
Stabilisation splint (SS) vs Non-occluding splint Pain (unpleasantness/intensity/palpation) · Patients with pain dysfunction syndrome (PDS) of all degrees of severity · 3 months or less Stabilisation splint therapy for temporomandibular pain dysfunction syndrome (2004) · Cochrane | RR 1.44 [0.81, 2.58] | 3 studies | Ungraded |
Stabilisation splint (SS) vs Non-occluding splint Movement (increase in maximal mouth opening) · Patients with pain dysfunction syndrome (PDS) of all degrees of severity · 3 months or less Stabilisation splint therapy for temporomandibular pain dysfunction syndrome (2004) · Cochrane | MD 1.45 [-1.47, 4.37] | 1 study | Ungraded |
Stabilisation splint (SS) vs Relaxation Pain (reduction in pain on palpation) · Patients with pain dysfunction syndrome (PDS) of all degrees of severity · 3 months or less Stabilisation splint therapy for temporomandibular pain dysfunction syndrome (2004) · Cochrane | SS vs relaxation (Okeson 1983; Winocur 2002): reduction in pain on palpation. Okeson 1983 showed a significant reduction favouring SS; Winocur 2002 did not. Significant heterogeneity (P<0.01, I2=98.3%) meant the data… | 2 studies | Ungraded |
Stabilisation splint (SS) vs Biofeedback/stress management Helkimo clinical dysfunction index · Patients with pain dysfunction syndrome (PDS) of all degrees of severity · 3 months or less Stabilisation splint therapy for temporomandibular pain dysfunction syndrome (2004) · Cochrane | RR 1.11 [0.64, 1.92] | 1 study | Ungraded |
Stabilisation splint (SS) vs Acupuncture Pain (palpation and on movement) · Patients with pain dysfunction syndrome (PDS) of all degrees of severity · 3 months or less Stabilisation splint therapy for temporomandibular pain dysfunction syndrome (2004) · Cochrane | RR 0.63 [0.24, 1.65] | 2 studies | Ungraded |
Stabilisation splint (SS) vs Biofeedback/stress management Pain (severity/muscle palpation) · Patients with pain dysfunction syndrome (PDS) of all degrees of severity · 3 months or less Stabilisation splint therapy for temporomandibular pain dysfunction syndrome (2004) · Cochrane | MD 0.30 [-0.48, 1.08] | 1 study | Ungraded |
Stabilisation splint (SS) vs Jaw exercises Pain (TMJ, muscle, on movement) · Patients with pain dysfunction syndrome (PDS) of all degrees of severity · up to 6 months Stabilisation splint therapy for temporomandibular pain dysfunction syndrome (2004) · Cochrane | SS vs jaw exercises (Magnusson 1999): improvements in all pain outcomes (TMJ pain, muscle pain, pain on movement) for both groups at 3 and 6 months; no statistically significant between-group difference at any time… | 1 study | Ungraded |
Stabilisation splint (SS) vs Relaxation Movement (maximal mouth opening) · Patients with pain dysfunction syndrome (PDS) of all degrees of severity · 3 months or less Stabilisation splint therapy for temporomandibular pain dysfunction syndrome (2004) · Cochrane | SS vs relaxation (Okeson 1983; Winocur 2002): change in maximal mouth opening (active/comfortable and assisted/painful). Significant heterogeneity (active/comfortable P<0.01, I2=92.9%; assisted/painful P<0.01, I2=94%);… | 2 studies | Ungraded |
Stabilisation splint (SS) vs Biofeedback/stress management Depression (CES-D, POMS) · Patients with pain dysfunction syndrome (PDS) of all degrees of severity · 3 months or less Stabilisation splint therapy for temporomandibular pain dysfunction syndrome (2004) · Cochrane | MD 5.50 [1.49, 9.51] | 1 study | Ungraded |
Direct resin composite veneer vs Indirect resin composite veneer Colour match (aesthetic achievement) · Patients with permanent anterior teeth with intrinsic staining suitable for laminate veneer restorations Direct versus indirect veneer restorations for intrinsic dental stains (2004) · Cochrane | Planned outcome; colour match was not reported by the single included trial (Meijering 1998). | 0 studies | No studies |
Stabilisation splint (SS) vs Non-occluding splint Overall improvement of symptoms · Patients with pain dysfunction syndrome (PDS) of all degrees of severity · 3 months or less Stabilisation splint therapy for temporomandibular pain dysfunction syndrome (2004) · Cochrane | RR 1.13 [0.79, 1.61] | 2 studies | Ungraded |
Stabilisation splint (SS) vs Jaw exercises Overall improvement · Patients with pain dysfunction syndrome (PDS) of all degrees of severity · up to 6 months Stabilisation splint therapy for temporomandibular pain dysfunction syndrome (2004) · Cochrane | SS vs jaw exercises (Magnusson 1999): overall improvement at 3 months and greater than 3 months; no statistically significant between-group difference; a follow-up questionnaire 1 to 4 years later showed a lasting… | 1 study | Ungraded |
Ceramic inlays (all types) vs Composite resin inlay Outcome NR · Adults who require restorative treatment in posterior teeth Ceramic inlays for restoring posterior teeth (2003) · Cochrane | One randomised controlled trial (Gladys 1995) compared ceramic and resin composite inlays over 3 years, but it was excluded because the study design (parallel-group or split-mouth) was not clearly described; no… | 0 studies | No studies |
Ceramic inlays (all types) vs Amalgam Outcome NR · Adults who require restorative treatment in posterior teeth Ceramic inlays for restoring posterior teeth (2003) · Cochrane | No eligible randomised controlled trial comparing ceramic inlays with amalgam restorations was identified; this planned comparison could not be evaluated. | 0 studies | No studies |
Occlusal adjustment (OA) vs Placebo Psychosocial outcomes · Adults (aged 18 years or older) with clinically diagnosed temporomandibular disorders (TMD) Occlusal adjustment for treating and preventing temporomandibular joint disorders (2003) · Cochrane | There were no data on psychosocial outcomes, costs or quality of life in any of the trials. | 0 studies | No studies |
Occlusal adjustment (OA) vs Placebo Headache (severity) · Adults (aged 18 years or older) with clinically diagnosed temporomandibular disorders (TMD) Occlusal adjustment for treating and preventing temporomandibular joint disorders (2003) · Cochrane | OR 0.90 [0.13, 6.08] | 1 study · 18 participants | Ungraded |
Occlusal adjustment (OA) vs Reassurance Pain (frequency) · Adults (aged 18 years or older) with clinically diagnosed temporomandibular disorders (TMD) Occlusal adjustment for treating and preventing temporomandibular joint disorders (2003) · Cochrane | OR 0.13 [0.01, 2.58] | 1 study · 50 participants | Ungraded |
Occlusal adjustment (OA) vs Reassurance Headache (frequency) · Adults (aged 18 years or older) with clinically diagnosed temporomandibular disorders (TMD) Occlusal adjustment for treating and preventing temporomandibular joint disorders (2003) · Cochrane | OR 1.40 [0.45, 4.35] | 1 study · 50 participants | Ungraded |
Occlusal adjustment (OA) vs Placebo Pain (severity) · Adults (aged 18 years or older) with clinically diagnosed temporomandibular disorders (TMD) Occlusal adjustment for treating and preventing temporomandibular joint disorders (2003) · Cochrane | OR 0.5 [0.07, 3.85] | 1 study · 18 participants | Ungraded |
Occlusal adjustment (OA) vs No treatment Pain (severity) · Adults (aged 18 years or older) with clinically diagnosed temporomandibular disorders (TMD) Occlusal adjustment for treating and preventing temporomandibular joint disorders (2003) · Cochrane | OR 0.10 [0.00, 2.15] | 1 study · 17 participants | Ungraded |
Ceramic inlays (all types) vs Gold inlay Aesthetic satisfaction (colour match) · Adults who require restorative treatment in posterior teeth Ceramic inlays for restoring posterior teeth (2003) · Cochrane | Information on aesthetic satisfaction could not be obtained from this study as it did not use the tooth-coloured restorations as the control group. | 0 studies | No studies |
Occlusal adjustment (OA) vs Placebo Relief of globus · Adults (aged 18 years or older) with clinically diagnosed temporomandibular disorders (TMD) Occlusal adjustment for treating and preventing temporomandibular joint disorders (2003) · Cochrane | OR 6.0 [0.72, 49.84] | 1 study · 17 participants | Ungraded |
Ceramic inlays (all types) vs Gold inlay Failure rate (longevity) at 5 years · Adults who require restorative treatment in posterior teeth · 5 years Ceramic inlays for restoring posterior teeth (2003) · Cochrane | OR 1.12 [0.08, 15.0] | 1 study · 20 participants | Ungraded |
Occlusal adjustment (OA) vs Placebo Headache (frequency) · Adults (aged 18 years or older) with clinically diagnosed temporomandibular disorders (TMD) Occlusal adjustment for treating and preventing temporomandibular joint disorders (2003) · Cochrane | OR 0.90 [0.13, 6.08] | 1 study · 18 participants | Ungraded |
Occlusal adjustment (OA) vs No treatment Headache (severity) · Adults (aged 18 years or older) with clinically diagnosed temporomandibular disorders (TMD) Occlusal adjustment for treating and preventing temporomandibular joint disorders (2003) · Cochrane | OR 0.10 [0.00, 2.15] | 1 study · 17 participants | Ungraded |
Occlusal adjustment (OA) vs Reassurance Overall symptoms improvement · Adults (aged 18 years or older) with clinically diagnosed temporomandibular disorders (TMD) Occlusal adjustment for treating and preventing temporomandibular joint disorders (2003) · Cochrane | OR 3.12 [0.12, 80.39] | 1 study · 50 participants | Ungraded |
Occlusal adjustment (OA) vs Reassurance Limitation of movement (range of mandibular movement) · Adults (aged 18 years or older) with clinically diagnosed temporomandibular disorders (TMD) Occlusal adjustment for treating and preventing temporomandibular joint disorders (2003) · Cochrane | Additional clinical outcomes reported included range of mandibular movement (Vallon 1991); no pooled effect estimate was reported. | 1 study | Ungraded |
Occlusal adjustment (OA) vs No treatment Pain (frequency) · Adults (aged 18 years or older) with clinically diagnosed temporomandibular disorders (TMD) Occlusal adjustment for treating and preventing temporomandibular joint disorders (2003) · Cochrane | OR 0.10 [0.00, 2.15] | 1 study · 17 participants | Ungraded |
Occlusal adjustment (OA) vs No treatment Headache (frequency) · Adults (aged 18 years or older) with clinically diagnosed temporomandibular disorders (TMD) Occlusal adjustment for treating and preventing temporomandibular joint disorders (2003) · Cochrane | OR 0.10 [0.00, 2.15] | 1 study · 17 participants | Ungraded |
Occlusal adjustment (OA) vs Placebo Pain (frequency) · Adults (aged 18 years or older) with clinically diagnosed temporomandibular disorders (TMD) Occlusal adjustment for treating and preventing temporomandibular joint disorders (2003) · Cochrane | OR 0.5 [0.07, 3.85] | 1 study · 18 participants | Ungraded |
Occlusal adjustment (OA) vs No treatment or placebo (control) Incidence of TMD symptoms · Healthy subjects without TMD at baseline (children, adolescents and young adults) Occlusal adjustment for treating and preventing temporomandibular joint disorders (2003) · Cochrane | OR 0.43 [0.14, 1.37] | 3 studies · 300 participants | Ungraded |
Ceramic inlays (all types) vs Composite resin (direct restoration) Outcome NR · Adults who require restorative treatment in posterior teeth Ceramic inlays for restoring posterior teeth (2003) · Cochrane | No eligible randomised controlled trial comparing ceramic inlays with composite resin (direct) restorations was identified; this planned comparison could not be evaluated. | 0 studies | No studies |