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What do systematic reviews say?

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Evidence found and GRADE certainty

486 questions · 503 findings · 36 reviews · Oral and maxillofacial surgery · related questions CL0289

No studies found 116 · 23.1%GRADE not reported 303 · 60.2%Very low 66 · 13.1%Low 12 · 2.4%Moderate 2 · 0.4%High 4 · 0.8%

Autologous platelet‐rich plasma vs placebo or no treatment

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

It is very uncertain whether platelet rich plasma changes presence of dry socket compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Artemisia desertorum spreng (Yunnan) vs placebo

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Artemisia desertorum spreng (Yunnan) showed no clear difference in presence of dry socket compared with placebo; GRADE not reported.

1 finding from 1 review

Autofluorescence-guided bone surgery vs Tetracycline fluorescence-guided bone surgery

Healing of MRONJ (mucosal integrity) · People with MRONJ referred for surgical treatment

It is very uncertain whether autofluorescence-guided bone surgery changes healing of MRONJ (mucosal integrity) compared with tetracycline fluorescence-guided bone surgery (very low certainty).

1 finding from 1 review

Topical anaesthetic gel (prilocaine-lidocaine) vs Eugenol

Pain at 48 hours (VAS 0-10) · Adults (>18 years) with established dry socket following permanent tooth extraction

Topical anaesthetic gel (prilocaine-lidocaine) showed no clear difference in pain at 48 hours (VAS 0-10) compared with eugenol; GRADE not reported.

1 finding from 1 review

Teriparatide 56.5 microg weekly in addition to standard care vs Teriparatide 20 microg daily in addition to standard care

Healing of MRONJ (remission) · People with established (manifest) MRONJ

It is very uncertain whether teriparatide 56.5 microg weekly in addition to standard care changes healing of MRONJ (remission) compared with teriparatide 20 microg daily in addition to standard care (very low certainty).

1 finding from 1 review

Tap water irrigation (monoject syringe) vs No rinsing

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Tap water irrigation (monoject syringe) led to lower presence of dry socket compared with no rinsing; GRADE not reported.

1 finding from 1 review

Honey (Manuka, topical) vs Chlorhexidine rinse (0.2%)

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Honey (Manuka, topical) showed no clear difference in presence of dry socket compared with chlorhexidine rinse (0.2%); GRADE not reported.

1 finding from 1 review

Artemisia desertorum spreng (Shahaosan) vs Artemisia desertorum spreng (Yunnan)

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Artemisia desertorum spreng (Shahaosan) showed no clear difference in presence of dry socket compared with artemisia desertorum spreng (Yunnan); GRADE not reported.

1 finding from 1 review

Dental extraction protocol with plasma rich in growth factors (PRGF) inserted into the postextraction alveolus vs Standard dental extraction protocol without PRGF

MRONJ (incidence proportion) · People with cancer treated with intravenous bisphosphonates undergoing dental extractions (at risk of MRONJ)

It is very uncertain whether dental extraction protocol with plasma rich in growth factors (PRGF)… changes MRONJ (incidence proportion) compared with standard dental extraction protocol without PRGF (very low certainty).

1 finding from 1 review

Dental examinations at three-month intervals and preventive treatments vs usual care

MRONJ (incidence rate: cases per patient-year) · Men with metastatic prostate cancer receiving intravenous zoledronic acid (at risk of MRONJ)

It is very uncertain whether dental examinations at three-month intervals and preventive treatments changes MRONJ (incidence rate: cases per patient-year) compared with standard care (very low certainty).

1 finding from 1 review

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

Presence of dry socket · People undergoing tooth extraction (21 of 23 trials: healthy patients undergoing impacted third molar extraction; 1 routine intra-alveolar…

Systemic antibiotic prophylaxis (any regimen; topical therapy… may leads to lower dry socket compared with placebo (low certainty).

1 finding from 1 review

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

Infectious complications · People undergoing tooth extraction (21 of 23 trials: healthy patients undergoing impacted third molar extraction; 1 routine intra-alveolar…

Systemic antibiotic prophylaxis (any regimen; topical therapy… may leads to lower postsurgical infectious complications compared with placebo (low certainty).

1 finding from 1 review

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

Swelling (7th day) · People undergoing tooth extraction (21 of 23 trials: healthy patients undergoing impacted third molar extraction; 1 routine intra-alveolar…

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes swelling (7th day) compared with placebo (very low certainty).

1 finding from 1 review

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing tooth extraction (21 of 23 trials: healthy patients undergoing impacted third molar extraction; 1 routine intra-alveolar…

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes pain (continuous, VAS 0-10 cm, 7th day) compared with placebo (very low certainty).

1 finding from 1 review

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

Pain (dichotomous, present/absent on 6th-7th day) · People undergoing tooth extraction (21 of 23 trials: healthy patients undergoing impacted third molar extraction; 1 routine intra-alveolar…

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes presence of pain (dichotomous, yes/no on 6th-7th day) compared with placebo (very low certainty).

1 finding from 1 review

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

Trismus (dichotomous, 7th day) · People undergoing tooth extraction (21 of 23 trials: healthy patients undergoing impacted third molar extraction; 1 routine intra-alveolar…

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes trismus (dichotomous, 7th day) compared with placebo (very low certainty).

1 finding from 1 review