Overweight/obesity risk · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
Non-responsive complementary feeding showed no significant association with overweight/obesity across observational studies (very low certainty).
1 finding from 1 review
Weight gain · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
Narratively, restrictive NRCF style tended to favor excess weight and coercive/pressuring style tended to favor lower weight (3 of 5 studies each; ungraded).
1 finding from 1 review
Overweight/obesity risk · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
Among observational studies, baby-led weaning was associated with lower odds of overweight/obesity than other feeding models (OR 0.37, 95% CI 0.25 to 0.55), but certainty is very low.
1 finding from 1 review
Infant weight-length gain (achievement of adequate weight) · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
Baby-led weaning/BLISS did not significantly influence infant weight-length (adequate weight) gain versus other complementary feeding models (pooled OR 1.36, 95% CI 0.18 to 10.51; ungraded).
1 finding from 1 review
Pulp exposure during caries removal · Children with dentine caries in primary and permanent teeth
Partial caries removal was reported to reduce pulp-exposure risk by 77% versus complete caries removal (RR 0.23; ungraded).
1 finding from 1 review
RR 0.23 [0.08, 0.69]
2 studies
GRADE not reported
Choking · Healthy children aged 6–24 months in Western industrialized countries
No eligible studies of RCF and choking were found.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Pulp exposure during caries removal · Children (3-11 years) with symptomless, vital dentine caries in primary molars
Partial caries removal reduced the reported risk of pulp exposure versus complete caries removal in primary teeth (RR 0.24; ungraded).
1 finding from 1 review
RR 0.24 [0.06, 0.90]
262 participants
GRADE not reported
Food purchasing · Children and adolescents (general population, aged under 20 years)
Across five studies, 40% showed any association of potential public health harm for food purchasing (very low certainty).
1 finding from 1 review
Physical growth / weight gain · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
Two RCTs suggest responsive complementary feeding leads to better weight gain in the first two years, though effects were small and not always sustained (ungraded).
1 finding from 1 review
Overweight/obesity risk · Healthy children aged 6–24 months in Western industrialized countries
BLW was associated with lower overweight/obesity risk in observational studies, but the certainty was very low.
1 finding from 1 review
Choking · Healthy children aged 6–24 months in Western industrialized countries
No statistically significant difference in choking events between BLW/BLISS and TCF was reported.
1 finding from 1 review
no estimate extracted
6 studies
GRADE not reported
Overweight/obesity risk · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
In RCTs, BLISS did not significantly change overweight/obesity risk versus traditional feeding (RR 0.15, 95% CI 0.00 to 17.79; low certainty).
1 finding from 1 review
Overweight/obesity risk · Healthy children aged 6–24 months in Western industrialized countries
NRCF showed no significant association with overweight/obesity across the reported comparisons (very low certainty).
1 finding from 1 review
Choking · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
No systematic reviews or studies assessed choking risk for RCF or NRCF (only BLW/BLISS); this is an evidence gap.
1 finding from 1 review
Choking · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
No significant difference in choking risk was found between BLW/BLISS-fed and traditionally fed infants (ungraded).
1 finding from 1 review
Overweight/obesity risk · Healthy children aged 6–24 months in Western industrialized countries
BLISS did not show a statistically significant reduction in overweight/obesity risk at 24 months (low certainty).
1 finding from 1 review
Food preference · Children and adolescents (general population, aged under 20 years)
In crossover studies with binary outcomes, food marketing increased food preference (OR 3.49, 95% CI 2.03 to 6.22; ungraded).
1 finding from 1 review
OR 3.49 [2.03, 6.22]
4 studies
GRADE not reported
Pulpal disease (signs/symptoms of pulp necrosis) · Children with dentine caries in primary and permanent teeth
The reported estimate did not show a clear difference in pulpal disease after partial versus complete caries removal (ungraded).
1 finding from 1 review
RR 0.27 [0.05, 1.60]
3 studies
GRADE not reported
Disease-free survival · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
1 finding from 1 review
Induction cisplatin+5-FU+docetaxel vs cisplatin+5-FU: disease-free survival HR 0.72 (95% CI 0.57 to 0.91, P = 0.006; Vermorken 2007). Prior to concurrent chemoradiation: Posner 2007 HR 0.71 (0.56 to 0.90, P = 0.005).…
2 studies
GRADE not reported
Overall survival, induction cisplatin + 5-fluorouracil + docetaxel prior to concurrent chemoradiation (cisplatin) vs concurrent chemoradiation (cisplatin) · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
Induction chemotherapy plus locoregional treatment (radiotherapy… showed no clear difference in overall survival, induction cisplatin + 5-fluorouracil + docetaxel… compared with locoregional treatment (radiotherapy and/or surgery) alone (low certainty).
1 finding from 1 review