Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,916 questions · 3,207 findings · 167 reviews · related questions CL0289

No studies found 596 · 18.6%GRADE not reported 1,666 · 51.9%Very low 603 · 18.8%Low 252 · 7.9%Moderate 78 · 2.4%High 12 · 0.4%

Systemic antibiotic (oral penicillin 500 mg) plus analgesic vs Placebo plus analgesic

Total number of paracetamol (acetaminophen) with codeine (Tylenol) tablets · Adults over 18 years presenting with a single tooth with a clinical diagnosis of irreversible pulpitis

Systemic antibiotic (oral penicillin 500 mg) plus analgesic showed no clear difference in total number of paracetamol (acetaminophen) with codeine (Tylenol)… compared with placebo plus analgesic (low certainty).

1 finding from 1 review

Pycnogenol chewing gum vs Placebo chewing gum

VSC: methyl sulphide · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Pycnogenol chewing gum showed no clear difference in VSC: methyl sulphide compared with placebo chewing gum; GRADE not reported.

1 finding from 1 review

Acupressure at P6 point with sea band vs sham

Presence or absence of gagging · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

The review found no eligible studies for this question.

1 finding from 1 review

Mechanical tongue cleaning (tongue scraper) vs No tongue cleaning

Dentist-reported organoleptic test (OLT) score (scale 0 to 5) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

It is very uncertain whether mechanical tongue cleaning (tongue scraper) changes dentist-reported organoleptic test (OLT) score (scale 0 to 5) compared with no tongue cleaning (very low certainty).

1 finding from 1 review

Miswak (Salvadora persica) stick vs Chlorhexidine mouthwash

Dentist-reported organoleptic test (OLT) score (scale 0 to 5) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

It is very uncertain whether miswak (Salvadora persica) stick changes dentist-reported organoleptic test (OLT) score (scale 0 to 5) compared with chlorhexidine mouthwash (very low certainty).

1 finding from 1 review

PRP (platelet-rich plasma) in cellulose foam placed in extraction socket vs placebo, no treatment or surveillance only

Incidence of ORN · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)

It is very uncertain whether PRP (platelet-rich plasma) in cellulose foam placed in extraction… changes incidence of ORN compared with no treatment/placebo (cellulose foam only) placed in extraction socket (very low certainty).

1 finding from 1 review

Hyperbaric oxygen (following replantation) vs control

Pulpal healing at 12 months · People with avulsed and replanted permanent (front) teeth

It is very uncertain whether hyperbaric oxygen (following replantation) changes pulpal healing at 12 months compared with control (very low certainty).

1 finding from 1 review

Individualised oral care plan based on a multidisciplinary assessment vs usual care

Plaque · Adults aged 22 to 57 years with mixed levels of ID; setting residential
1 finding from 1 review
  • Oral hygiene interventions for people with intellectual disabilities 2019 · Cochrane All outcomes
    Medium term (6 weeks to 12 months)
    Individualised oral care plan vs usual care. Subjective Oral Hygiene Rating scale 1-5 and Improvement Differential, mean 12 months; SOHR 2.97 (intervention) vs 3.10 (control); improvement differential 38% vs 5%; 79…
    1 study · 79 participants
    Very low

Acupressure at P6 point with sea band vs sham

Reduction in gagging (patient-reported) · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

It is very uncertain whether acupressure at P6 point with sea band changes reduction in gagging (patient-reported) compared with sham (dummy) acupressure (very low certainty).

1 finding from 1 review

Acupuncture at P6 point with sedation vs Sham (dummy) acupuncture with sedation

Reduction in gagging (patient-reported) · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

It is very uncertain whether acupuncture at P6 point with sedation changes reduction in gagging (patient-reported – dichotomous) compared with sham (dummy) acupuncture with sedation (very low certainty).

1 finding from 1 review

Professionally-applied 12,300 ppm F APF foam, every 2 months vs 0 ppm F placebo foam

Number of participants with more severe DLs (severity of DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

The review found no eligible studies for this question.

1 finding from 1 review

Mechanical tongue cleaning (tongue scraper) vs No tongue cleaning

Volatile sulphur compounds (VSC), halimeter · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Mechanical tongue cleaning (tongue scraper) showed no clear difference in volatile sulphur compounds (VSC) compared with no tongue cleaning; GRADE not reported.

1 finding from 1 review

Acupressure at P6 point with sea band plus sedation vs Sham (dummy) acupressure with sedation

Reduction in gagging (patient-reported) · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

It is very uncertain whether acupressure at P6 point with sea band plus sedation changes reduction in gagging (patient-reported) compared with sham (dummy) acupressure with sedation (very low certainty).

1 finding from 1 review

Acupressure at P6 point with device vs sham

Presence or absence of gagging · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

The review found no eligible studies for this question.

1 finding from 1 review

Hinokitiol gel vs Placebo gel

VSC: hydrogen sulphide · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Hinokitiol gel showed no clear difference in VSC: hydrogen sulphide compared with placebo gel; GRADE not reported.

1 finding from 1 review

Combined HBO and perioperative antibiotics prior to dental implant therapy vs antibiotics alone

Incidence of ORN · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)

It is very uncertain whether combined HBO and perioperative antibiotics prior to dental implant… changes incidence of ORN compared with antibiotics alone prior to dental implant therapy (very low certainty).

1 finding from 1 review

Professionally-applied 12,300 ppm F APF foam, every 2 months vs 0 ppm F placebo foam

Number of participants with new demineralised lesions (DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

Professionally-applied 12,300 ppm F APF foam, every 2 months may leads to lower number of participants with new demineralised lesions (DLs) compared with 0 ppm F placebo foam (low certainty).

1 finding from 1 review