Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,032 questions · 3,358 findings · 190 reviews · related questions CL0289

No studies found 599 · 17.8%GRADE not reported 1,759 · 52.4%Very low 612 · 18.2%Low 269 · 8%Moderate 107 · 3.2%High 12 · 0.4%

Doxycycline + SRP vs SRP

Clinical attachment level (CAL) · Adults with aggressive periodontitis

It is very uncertain whether doxycycline + SRP changes clinical attachment level (CAL) compared with SRP (very low certainty).

3 findings from 1 review

Azithromycin + SRP vs SRP

Percentage of closed pockets · Adults with periodontitis (chronic and aggressive)

Azithromycin + SRP showed no clear difference in percentage of closed pockets compared with SRP; GRADE not reported.

2 findings from 1 review

Doxycycline + SRP vs SRP

Probing pocket depth · Adults with aggressive periodontitis

Doxycycline + SRP showed no clear difference in probing pocket depth compared with SRP; GRADE not reported.

3 findings from 1 review

General ventilation (e.g. natural ventilation, exhaust fans, opening windows) vs No general ventilation / standard operatory

Outcome not reported · Dental healthcare providers (dentist, dental surgery assistant, dental hygienist, dental technologist, dental laboratory staff, dental…

The review found no eligible studies for this question.

1 finding from 1 review

Amoxicillin + metronidazole + SRP vs SRP

Probing pocket depth · Adults with periodontitis (chronic and aggressive)

Amoxicillin + metronidazole + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.

3 findings from 1 review

Topical clobetasol propionate vs Topical ciclosporin

Pain resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether topical clobetasol propionate changes pain resolution compared with topical ciclosporin (very low certainty).

1 finding from 1 review

Hypnosis vs Conventional treatment

Physical/verbal resistance and self-reported pain during LA (other studies) · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

Hypnosis led to lower physical/verbal resistance and self-reported pain during LA (other… compared with conventional treatment; GRADE not reported.

1 finding from 1 review

High-volume evacuation (HVE) vs No HVE

Reduction in contamination of aerosols on operator's face shield/mask (RCTs) · People undergoing aerosol-generating procedures (AGPs) in a dental setting

High-volume evacuation (HVE) showed no clear difference in reduction in contamination of aerosols on operator's face… compared with no HVE; GRADE not reported.

1 finding from 1 review

Doxycycline + SRP vs Metronidazole + SRP

Probing pocket depth · Adults with aggressive periodontitis

Doxycycline + SRP showed no clear difference in probing pocket depth compared with metronidazole + SRP; GRADE not reported.

3 findings from 1 review

Clindamycin + SRP vs Metronidazole + SRP

Probing pocket depth · Adults with aggressive periodontitis

Clindamycin + SRP showed no clear difference in probing pocket depth compared with metronidazole + SRP; GRADE not reported.

3 findings from 1 review

No additional acid etching (self-etch adhesive alone) after Er,Cr:YSGG preparation vs Prior acid etching before self-etch adhesive after Er,Cr:YSGG preparation

Incidence of microleakage · Er,Cr:YSGG laser-prepared cavities restored with self-etch adhesive systems (in vitro)

At the dentin margin, prior acid etching with self-etch adhesives significantly reduced microleakage (RR 2.44, 95% CI 1.38-4.34; ungraded).

3 findings from 1 review

Amoxicillin + metronidazole + SRP vs Clarithromycin + SRP

Clinical attachment level (CAL) · Adults with aggressive periodontitis

Amoxicillin + metronidazole + SRP showed no clear difference in clinical attachment level (CAL) compared with clarithromycin + SRP; GRADE not reported.

2 findings from 1 review

Topical clobetasol propionate vs Topical tacrolimus

Pain (mean VAS score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical clobetasol propionate showed no clear difference in pain (mean VAS score) compared with topical tacrolimus; GRADE not reported.

1 finding from 1 review

Amoxicillin + clavulanate + SRP vs SRP

Probing pocket depth · Adults with chronic periodontitis

Amoxicillin + clavulanate + SRP showed no clear difference in probing pocket depth compared with SRP; GRADE not reported.

3 findings from 1 review