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Evidence found and GRADE certainty

3,032 questions · 3,358 findings · 190 reviews · related questions CL0289

No studies found 599 · 17.8%GRADE not reported 1,759 · 52.4%Very low 612 · 18.2%Low 269 · 8%Moderate 107 · 3.2%High 12 · 0.4%

Nickel-titanium archwire vs Multistranded stainless steel archwire

Harms (pain) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth
1 finding from 1 review
  • Orthodontic treatment for crowded teeth in children 2021 · Cochrane All outcomes
    first days
    No difference in overall pain, but more pain with nickel-titanium at 12 hours and day 1 (morning, afternoon, bedtime) vs multistranded stainless steel (Sandhu 2013). Narrative; no pooled estimate.
    1 study
    GRADE not reported

Induction chemotherapy plus locoregional treatment (radiotherapy and/or surgery) vs Locoregional treatment (radiotherapy and/or surgery) alone

Disease-free survival · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

Induction chemotherapy plus locoregional treatment (radiotherapy… led to lower disease-free survival, induction platinum + 5-fluorouracil prior to… compared with locoregional treatment (radiotherapy and/or surgery) alone; GRADE not reported.

1 finding from 1 review

Copper nickel-titanium archwire vs Nickel-titanium archwire

Amount of crowding · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

It is very uncertain whether copper nickel-titanium archwire changes amount of crowding (Little's Irregularity Index) at 12 weeks compared with nickel-titanium archwire (very low certainty).

1 finding from 1 review

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs Supra-gingival scaling

Plasma level of IL-6 (pg/mL) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension

Intensive periodontal treatment (subgingival SRP with or without… showed no clear difference in plasma level of IL-6 (pg/mL) compared with supra-gingival scaling; GRADE not reported.

3 findings from 1 review

Quad-helix plus multi-bracket appliance vs Expansion arch plus multi-bracket appliance

Canine expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…

Quad-helix plus multi-bracket appliance showed no clear difference in canine expansion compared with expansion arch plus multi-bracket appliance; GRADE not reported.

1 finding from 1 review

Fixed tooth-borne expansion (quad-helix) vs observation

Molar expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…

Fixed tooth-borne expansion (quad-helix) probably leads to higher molar expansion (inter-molar distance) compared with observation (no treatment) (moderate certainty).

1 finding from 1 review

Schwarz appliance vs No active treatment (control)

Amount of crowding (change in mandibular crowding) at 8 weeks · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

It is very uncertain whether schwarz appliance changes amount of crowding (lower arch crowding, change) at 9 months compared with no active treatment (control) (very low certainty).

1 finding from 1 review

Fixed tooth-borne expansion (Hyrax) vs Fixed tooth-tissue-borne expansion (Haas)

Molar expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…

Fixed tooth-borne expansion (Hyrax) showed no clear difference in molar expansion (inter-molar distance) compared with fixed tooth-tissue-borne expansion (Haas) (moderate certainty).

1 finding from 1 review

Extraction of the primary (baby) canine (single primary tooth extraction) vs No extraction (non-intervention control)

Time taken for the canine to erupt into the mouth · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)

The review found no eligible studies for this question.

1 finding from 1 review

Fixed tooth-borne expansion (Hyrax) vs observation

Crossbite correction · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…

Fixed tooth-borne expansion (Hyrax) probably leads to higher crossbite correction compared with observation (no treatment) (moderate certainty).

1 finding from 1 review

Fixed tooth-borne expansion (Hyrax) vs Bonded Hyrax (tooth/tissue-borne)

Molar expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…
1 finding from 1 review
  • Orthodontic treatment for posterior crossbites 2021 · Cochrane All outcomes
    3 months after completion of expansion
    Asanza 1997: banded 6 mm (min 4.3-max 7.2) vs bonded 5.9 mm (min 3.2-max 7.7); P=NS (no SD reported); no significant difference in tipping or symmetrical expansion
    1 study
    GRADE not reported

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

Presence of dry socket · People undergoing tooth extraction (21 of 23 trials: healthy patients undergoing impacted third molar extraction; 1 routine intra-alveolar…

Systemic antibiotic prophylaxis (any regimen; topical therapy… may leads to lower dry socket compared with placebo (low certainty).

1 finding from 1 review

ARP with xenograft (bone graft) vs Extraction alone

Complications (e.g. discomfort, pain and swelling) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…
1 finding from 1 review

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs No treatment (no periodontal treatment)

Plasma level of hs-CRP (mg/L) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension

Periodontal treatment (subgingival SRP with or without other… showed no clear difference in plasma level of hs-CRP (mg/L) compared with no treatment (no periodontal treatment); GRADE not reported.

4 findings from 1 review
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Double primary (canine and first molar) tooth extraction vs Single primary (canine) tooth extraction

Number of participants referred for surgical exposure of the PDC · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)

It is very uncertain whether double primary (canine and first molar) tooth extraction changes number of participants referred for surgical exposure of the PDC compared with single primary (canine) tooth extraction (very low certainty).

1 finding from 1 review

Nickel-titanium archwire vs Multistranded stainless steel archwire

Amount of crowding (change in mandibular crowding) at 8 weeks · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

It is very uncertain whether nickel-titanium archwire changes amount of crowding (change in mandibular crowding) at 8 weeks compared with multistranded stainless steel archwire (very low certainty).

1 finding from 1 review