Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,916 questions · 3,207 findings · 167 reviews · related questions CL0289

No studies found 596 · 18.6%GRADE not reported 1,666 · 51.9%Very low 603 · 18.8%Low 252 · 7.9%Moderate 78 · 2.4%High 12 · 0.4%

Traditional screening (referral card given if the inspecting dentist judges the child needs to see a dentist) vs No screening

Dental attendance · School children (aged 4 to 15 years), primary and secondary schools in the UK and India
1 finding from 1 review
  • School dental screening programmes for oral health 2022 · Cochrane All outcomes
    3 to 4 months
    Data not pooled; 6281 participants (4 RCTs); Very low. There was substantial heterogeneity, in part due to study design (3 cluster-RCTs and 1 individually randomised trial). We are unable to draw conclusions about this…
    4 studies · 6281 participants
    Very low

Periodontal treatment: scaling and root planing (SRP) plus advice vs Community care: advice only

Cardiovascular events · Patients with cardiovascular disease and chronic periodontitis
1 finding from 1 review

Artemisia desertorum spreng (Shahaosan) vs placebo

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Artemisia desertorum spreng (Shahaosan) showed no clear difference in presence of dry socket compared with placebo; GRADE not reported.

1 finding from 1 review

Cetylpyridinium chloride (CPC) vs Water

Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them

Cetylpyridinium chloride (CPC) may leads to lower reduction in level of contamination by particles >5 um (droplets) at… compared with water (low certainty).

3 findings from 1 review

Periodontal treatment (subgingival instrumentation, with or without antimicrobials/surgery) vs usual care or no treatment

Probing pocket depth (PPD/PD) · People with diabetes mellitus (type 1 or type 2, mostly type 2) and periodontitis, at least 16 years of age

Periodontal treatment (subgingival instrumentation, with or without… led to lower probing pocket depth (PPD/PD) compared with no active intervention/usual care; GRADE not reported.

1 finding from 1 review

Mindfulness plus medication vs Medication alone

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People aged 12 years and over with painful TMD lasting 3 months or longer
1 finding from 1 review

Single-visit root canal treatment vs Multiple-visit root canal treatment (two or more visits)

Analgesic (painkiller) use · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption

It is very uncertain whether single-visit root canal treatment changes analgesic (painkiller) use compared with multiple-visit root canal treatment (two or more visits) (very low certainty).

1 finding from 1 review

Amoxicillin + metronidazole + SRP vs Supragingival scaling (plus placebo)

All CVD-related death · People with periodontitis and metabolic syndrome (no CVD; primary prevention)

It is very uncertain whether scaling and root planing (SRP) plus antibiotics (amoxicillin and… changes all CVD-related death compared with supragingival scaling (plus placebo) (very low certainty).

1 finding from 1 review

Zinc oxide and eugenol (ZOE) vs Alvogyl (old formulation)

Success rate (radiographically‐assessed healing of cyst healing based on the Neer/Cole rating system) · Adults (>18 years) with established dry socket following permanent tooth extraction
1 finding from 1 review

Platelet-rich fibrin after bone surgery vs Bone surgery alone

Healing of MRONJ (mucosal integrity, absence of infection, and no re-intervention) · People with established (manifest) MRONJ

It is very uncertain whether platelet-rich fibrin after bone surgery changes healing of MRONJ (mucosal integrity, absence of infection, and no… compared with bone surgery alone (very low certainty).

1 finding from 1 review

Single-visit root canal treatment vs Multiple-visit root canal treatment (two or more visits)

Pain at two weeks (postobturation) · People aged 10 years or above requiring root canal treatment; permanent teeth with completely formed apex and without internal resorption

Single-visit root canal treatment showed no clear difference in pain at two weeks (postobturation) compared with multiple-visit root canal treatment (two or more visits); GRADE not reported.

1 finding from 1 review

Criteria-based screening with specific (personalised) referral letter vs Criteria-based screening with non-specific referral letter

Dental attendance at orthodontist · School children, secondary school in the UK (aged 11 to 13 years)

It is very uncertain whether criteria-based screening with specific (personalised) referral letter changes dental attendance at orthodontist compared with criteria-based screening with non-specific referral letter (very low certainty).

1 finding from 1 review

Recombinant bovine fibroblast growth factor gel vs control

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Recombinant bovine fibroblast growth factor gel led to lower presence of dry socket compared with control; GRADE not reported.

1 finding from 1 review