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Evidence found and GRADE certainty

2,916 questions · 3,207 findings · 167 reviews · related questions CL0289

No studies found 596 · 18.6%GRADE not reported 1,666 · 51.9%Very low 603 · 18.8%Low 252 · 7.9%Moderate 78 · 2.4%High 12 · 0.4%

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs Antifungal drugs not absorbed from GI tract

Empirical antifungal treatment · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs absorbed from GI tract showed no clear difference in empirical antifungal treatment compared with antifungal drugs not absorbed from GI tract; GRADE not reported.

1 finding from 1 review

Potassium nitrate/dimethyl isosorbide/polycarboxylate cement (KNO3/DMI/PCa) vs Polycarboxylate cement (PCa) alone

Clinical success (absence of periapical pathology, tenderness to pressure and fistula formation) at 24 months · Adults with asymptomatic teeth with vital carious pulp exposures
1 finding from 1 review
  • Hodosh 2003 (Analysis 3.1): all 18 patients receiving KNO3/DMI/PCa responded favourably (0/18 developed clinical symptoms) versus 10/12 in the PCa group. "The results in groups two and three were statistically…
    1 study · 30 participants
    GRADE not reported

Glycerrhetinic acid/antibiotic mixture vs Zinc oxide and eugenol (ZOE)

Clinical success (survival free of symptoms) at 24 months · Adults with asymptomatic teeth with vital carious pulp exposures
1 finding from 1 review
  • Shovelton 1971 (Analysis 1.1): 275 teeth followed for 2 years (235 at 6 months, 160 at 12 months, 85 analysed at 24 months). Success rates 50% to 80%. Ledermix and calcium hydroxide had the highest success rates,…
    1 study · 275 participants
    GRADE not reported

Antifungal drugs partially absorbed from GI tract (miconazole, clotrimazole) vs placebo or no treatment

Oral candidiasis (present) · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs partially absorbed from GI tract (miconazole,… led to lower oral candidiasis (present) compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs placebo or no treatment

Amount of analgesia · Patients with cancer receiving chemotherapy and/or radiotherapy

The review found no eligible studies for this question.

1 finding from 1 review

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs Antifungal drugs not absorbed from GI tract

Systemic fungal infection · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs absorbed from GI tract showed no clear difference in systemic fungal infection compared with antifungal drugs not absorbed from GI tract; GRADE not reported.

1 finding from 1 review

Occlusal splint vs Palatal splint

Comfort · People with sleep bruxism (tooth grinding or clenching); children (greater than 1 year old) and adults; diagnosis clinical,…
1 finding from 1 review
  • Occlusal splint versus palatal splint, comfort (median VAS 0 to 100 mm) (Dube 2004): occlusal splint 79.3 (SD 4.7) mm versus palatal splint 77.8 (8.1) mm; both rated as equally comfortable. No participant reported dry…
    1 study
    GRADE not reported

Occlusal splint vs Palatal splint

Preference (device preferred by participants) · People with sleep bruxism (tooth grinding or clenching); children (greater than 1 year old) and adults; diagnosis clinical,…
1 finding from 1 review
  • Occlusal splint versus palatal splint, preference (Dube 2004): all participants preferred the palatal splint rather than the occlusal splint; 71% felt the occlusal splint offered greater protection for their teeth. At…
    1 study
    GRADE not reported

Antifungal drugs partially absorbed from GI tract (miconazole, clotrimazole) vs placebo or no treatment

Empirical antifungal treatment · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs partially absorbed from GI tract (miconazole,… showed no clear difference in empirical antifungal treatment compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Non-metal carbon-fibre post and core (Category III; Composipost) vs Metal custom-cast post and core (Category I)

Clinical/technical failure (root fracture) · Participants with permanent endodontically-treated (root-filled) teeth for which a post is indicated to retain the final restoration

Non-metal carbon-fibre post and core (Category III; Composipost) led to lower clinical/technical failure (root fracture) compared with metal custom-cast post and core (Category I; gold alloy); GRADE not reported.

1 finding from 1 review

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs Antifungal drugs not absorbed from GI tract

Death associated with fungal infection · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs absorbed from GI tract showed no clear difference in death associated with fungal infection compared with antifungal drugs not absorbed from GI tract; GRADE not reported.

1 finding from 1 review

Occlusal splint vs Palatal splint

Number of bruxism episodes per hour of sleep (Epi/h) · People with sleep bruxism (tooth grinding or clenching); children (greater than 1 year old) and adults; diagnosis clinical,…

Occlusal splint showed no clear difference in number of bruxism episodes per hour of sleep (Epi/h) compared with palatal splint; GRADE not reported.

1 finding from 1 review

Oral paracetamol vs placebo

Participant‐reported pain relief of 50% or greater · Patients requiring surgical removal of a lower wisdom tooth or teeth, with baseline moderate to severe pain (surgery under local…

Paracetamol (single oral dose, any dose or formulation; subgroups up… led to higher achieving at least 50% pain relief at 6 hours (using pain relief… compared with placebo; GRADE not reported.

1 finding from 1 review

Potassium nitrate/polycarboxylate cement (KNO3/PCa) vs Polycarboxylate cement (PCa) alone

Clinical success (absence of periapical pathology, tenderness to pressure and fistula formation) at 24 months · Adults with asymptomatic teeth with vital carious pulp exposures
1 finding from 1 review
  • Hodosh 2003 (Analysis 3.1): 9/17 in the KNO3/PCa group and 10/12 in the PCa group developed clinical symptoms requiring endodontic therapy or extraction. No significance test reported for this specific contrast; no…
    1 study · 29 participants
    GRADE not reported

Antifungal drugs not absorbed from GI tract vs placebo or no treatment

Death associated with fungal infection · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs not absorbed from GI tract showed no clear difference in death associated with fungal infection compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs placebo or no treatment

Relief of pain · Patients with cancer receiving chemotherapy and/or radiotherapy

The review found no eligible studies for this question.

1 finding from 1 review