Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,916 questions · 3,207 findings · 167 reviews · related questions CL0289

No studies found 596 · 18.6%GRADE not reported 1,666 · 51.9%Very low 603 · 18.8%Low 252 · 7.9%Moderate 78 · 2.4%High 12 · 0.4%

Relaxation and imagery training vs control (e.g. usual activities)

Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Relaxation and imagery training showed no clear difference in average pain scores (0-100 VAS) compared with control (treatment as usual); GRADE not reported.

1 finding from 1 review

Referral to specialist agencies for support in relation to domestic violence vs no intervention

Frequency of physical assault by self report · Adults (16 years of age and older) who present to any healthcare setting with dental or facial injury

The review found no eligible studies for this question.

1 finding from 1 review

Topical methyl salicylate (Theraflex-TMJ) vs placebo

Spontaneous masseter muscle pain (numerical graph rating scale) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Topical methyl salicylate (Theraflex-TMJ) led to lower spontaneous masseter muscle pain (numerical graph rating scale) compared with placebo; GRADE not reported.

1 finding from 1 review

Neutron radiotherapy vs Conventional photon radiotherapy

Disease-free survival · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Neutron radiotherapy showed no clear difference in disease free survival compared with conventional photon radiotherapy; GRADE not reported.

1 finding from 1 review

Screening for domestic violence vs Different screening tool

Proportion of victims of domestic violence detected by self report · Adults (16 years of age and older) who present to any healthcare setting with dental or facial injury

The review found no eligible studies for this question.

1 finding from 1 review

Topical methyl salicylate (Theraflex-TMJ) vs placebo

Spontaneous pain in the TMJ (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Topical methyl salicylate (Theraflex-TMJ) led to lower spontaneous TMJ pain (numerical graph rating scale) compared with placebo; GRADE not reported.

1 finding from 1 review

Hyperfractionated radiotherapy vs Conventional (standard) fractionation radiotherapy

Locoregional control · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Hyperfractionated radiotherapy led to lower locoregional control compared with conventional (standard) fractionation radiotherapy; GRADE not reported.

1 finding from 1 review

Accelerated radiotherapy with concomitant boost vs Conventional (standard) fractionation radiotherapy

Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Accelerated radiotherapy with concomitant boost showed no clear difference in total mortality compared with conventional (standard) fractionation radiotherapy; GRADE not reported.

1 finding from 1 review

Oral glucosamine hydrochloride/chondroitin sulphate vs placebo

Total pain rating index (McGill Pain Questionnaire) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral glucosamine hydrochloride/chondroitin sulphate showed no clear difference in total pain rating index (McGill Pain Questionnaire) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral prazepam (benzodiazepine) vs placebo

No improvement in TMJ pain during mastication · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral prazepam (benzodiazepine) showed no clear difference in no improvement in TMJ pain during mastication compared with placebo; GRADE not reported.

2 findings from 1 review

Accelerated radiotherapy with concomitant boost vs Conventional (standard) fractionation radiotherapy

Disease-free survival · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…
1 finding from 1 review

Hypnosis vs No hypnosis (no hypnotic intervention)

Completion of treatment · Children and adolescents (0 to 16 years) needing dental treatment

The review found no eligible studies for this question.

1 finding from 1 review
  • Completion of treatment was a protocol-planned primary outcome but was not reported as an outcome by any of the three included studies; statistical analysis and meta-analysis were not possible due to the insufficient…
    Studies not reported
    No studies found

Split‐course radiotherapy (8 fractions, 30 Gy) vs Accelerated radiotherapy

Locoregional control · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Split-course radiotherapy showed no clear difference in locoregional control compared with accelerated radiotherapy; GRADE not reported.

1 finding from 1 review

Hypnosis vs No hypnosis (no hypnotic intervention)

Physiological measures during local anaesthesia (pulse rate and oxygen saturation) · Children aged 4 to 13 years with no previous dental experience undergoing restorative treatment with local anaesthesia (Gokli 1994)
1 finding from 1 review
  • With regard to oxygen saturation and pulse rate, only pulse rate was significantly lower in the hypnosis group (P = 0.005); oxygen saturation did not differ significantly. (Gokli 1994; cross-over, 29 children.)
    1 study · 29 participants
    GRADE not reported

Gelclair vs Sucralfate and mucaine

Mucositis severity (mild to moderate) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Gelclair showed no clear difference in mucositis severity (mild to moderate) compared with sucralfate and mucaine; GRADE not reported.

1 finding from 1 review

Pre-operative and post-operative radiotherapy vs Post-operative radiotherapy alone

Disease-free survival · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Pre-operative and post-operative radiotherapy showed no clear difference in disease free survival compared with post-operative radiotherapy alone; GRADE not reported.

1 finding from 1 review

Oral gabapentin vs placebo

Participants' assessment of global function (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral gabapentin (anticonvulsant) showed no clear difference in participants' assessment of global function (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Hyperfractionated radiotherapy vs Conventional (standard) fractionation radiotherapy

Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Hyperfractionated radiotherapy led to lower total mortality compared with conventional (standard) fractionation radiotherapy; GRADE not reported.

1 finding from 1 review

Absorbed drug (fluconazole or ketoconazole) vs Antifungal drugs not absorbed from GI tract

Mycological: eradication of oral candidiasis · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

Absorbed drug (fluconazole or ketoconazole) led to higher mycological: eradication of oral candidiasis compared with drug not absorbed from GI tract (amphotericin B or nystatin); GRADE not reported.

1 finding from 1 review

Split‐course radiotherapy (8 fractions, 30 Gy) vs Accelerated radiotherapy

Disease-free survival · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Split-course radiotherapy showed no clear difference in disease free survival compared with accelerated radiotherapy; GRADE not reported.

1 finding from 1 review