What do systematic reviews say?

Mucin spray (Saliva Orthana) vs Placebo spray (base without mucin)

Mucin spray (Saliva Orthana) led to lower patient satisfaction / desire to continue treatment compared with placebo spray (base without mucin); GRADE not reported.

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  Sweeney 1997: majority in both groups wished to continue the allocated spray, no significant difference (Analysis 1.3). Duxbury 1989: 14/30 (46.6%) and 15/30 (50%) wished to continue Saliva Orthana and the spray base…
  2 studies
  GRADE not reported

CMC spray / HCC spray / HCC gel vs Liquid margarine (and between each other)

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  Furumoto 1998 (crossover, n=28, medians/IQR): median day-10 oral dryness (lower = less dry): CMC spray 28.00 (3.06), HCC spray 28.75 (2.23), HCC gel 27.75 (3.62), margarine 29.25 (5.06). Only HCC gel showed a…
  1 study · 28 participants
  GRADE not reported

Cryotherapy (ice chips) 30 minutes vs Cryotherapy (ice chips) 60 minutes

Cryotherapy (ice chips) 30 minutes showed no clear difference in oral mucositis (moderate to severe) compared with cryotherapy (ice chips) 60 minutes; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.68 [0.36, 1.3]
  1 study · 178 participants
  GRADE not reported

Squeezable (modified) feeding bottle vs Rigid feeding bottle

Squeezable (modified) feeding bottle showed no clear difference in length (cm) compared with rigid feeding bottle; GRADE not reported.

• Feeding interventions for growth and development in infants with cleft lip, cleft palate or cleft lip and palate 2011 · Cochrane All outcomes

  >6 months
  MD 0.21 [-0.72, 1.14]
  2 studies · 130 participants
  GRADE not reported

Intestinal trefoil factor vs placebo

Intestinal trefoil factor led to lower oral mucositis (moderate to severe) compared with placebo; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.22 [0.1, 0.48]
  1 study · 99 participants
  GRADE not reported

Aloe vera vs placebo

Aloe vera led to lower oral mucositis (severe) compared with placebo; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.13 [0.02, 0.97]
  1 study · 61 participants
  GRADE not reported

Pilocarpine vs placebo

Pilocarpine showed no clear difference in oral mucositis (severe) compared with placebo; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.89 [0.58, 1.37]
  1 study · 34 participants
  GRADE not reported

Yangyin-humo decoction vs Traditional Western medicine

Yangyin-humo decoction showed no clear difference in oral mucositis (moderate to severe) compared with traditional Western medicine; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.65 [0.41, 1.02]
  1 study · 42 participants
  GRADE not reported

Clarithromycin vs no treatment

Systemic antibiotic (clarithromycin) showed no clear difference in oral mucositis (moderate to severe) compared with no treatment; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.69 [0.48, 1.01]
  1 study · 70 participants
  GRADE not reported

Oral care protocol vs usual care or no treatment

Oral care protocol showed no clear difference in oral mucositis (moderate to severe) compared with no treatment/usual care; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.91 [0.82, 1.02]
  1 study · 150 participants
  GRADE not reported

Intraoral device releasing Biotene Oral Balance gel vs Manually administered bolus of the same gel

Intraoral device releasing Biotene Oral Balance gel led to lower xerostomia (Xerostomia Inventory) compared with manually administered bolus of the same gel; GRADE not reported.

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes
  SMD -1.01 [-1.44, -0.58]
  1 study · 22 participants
  GRADE not reported

Arthroscopy vs open surgery

Arthroscopy showed no clear difference in maximum protrusion over 5 mm (clinical evaluation, 12 months) compared with open surgery; GRADE not reported.

• Arthroscopy for temporomandibular disorders 2011 · Cochrane All outcomes

  12 months
  Peto OR 0.12 [0.01, 2.09]
  2 studies · 40 participants
  GRADE not reported

Hydrolytic enzymes vs no treatment

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  no estimate extracted
  3 studies
  GRADE not reported

Shenqi-fanghou vs no treatment

Shenqi-fanghou showed no clear difference in oral mucositis (any severity) compared with no treatment; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.9 [0.8, 1]
  1 study · 140 participants
  GRADE not reported

Propantheline vs placebo

Propantheline showed no clear difference in oral mucositis (any severity) compared with placebo; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.4 [0.12, 1.31]
  1 study · 12 participants
  GRADE not reported

Arthroscopy vs open surgery

Arthroscopy showed no clear difference in interincisal opening over 35 mm (clinical evaluation, 12 months) compared with open surgery; GRADE not reported.

• Arthroscopy for temporomandibular disorders 2011 · Cochrane All outcomes

  12 months
  Peto OR 1.31 [0.31, 5.60]
  2 studies · 40 participants
  GRADE not reported

Sucralfate vs placebo or usual care

Sucralfate showed no clear difference in oral mucositis (moderate to severe) compared with placebo/usual care; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.75 [0.54, 1.04]
  4 studies
  GRADE not reported

Amifostine vs placebo/no treatment

It is very uncertain whether amifostine changes oral mucositis (severe) compared with placebo/no treatment (very low certainty).

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.68 [0.45, 1.03]
  9 studies · 845 participants
  Very low

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no treatment

Cryotherapy (ice chips) may leads to lower oral mucositis (severe) compared with no treatment (low certainty).

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.36 [0.17, 0.77]
  5 studies · 472 participants
  Low

Pilocarpine lozenge (3 mg or 5 mg) vs placebo control

• Interventions for the management of dry mouth: topical therapies 2011 · Cochrane All outcomes

  Single dose (up to 3 hours)
  Taweechaisupapong 2006 (crossover): participants reported a statistically significant improvement in oral dryness after both 3 mg and 5 mg pilocarpine lozenges vs placebo (P <= 0.05); no usable data presented. No…
  1 study · 33 participants
  GRADE not reported