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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
25 questions in 4 reviews · cluster CL0245
current versionsNo studies 0 · 0%Ungraded 20 · 80%Very low 2 · 8%Low 1 · 4%Moderate 2 · 8%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Resin infiltration vs Non-invasive measures (fluoride varnish/toothpaste, flossing, oral hygiene instruction, sham/standard of care) Radiographic progression of proximal caries lesions · Children and adults with non-cavitated proximal (interproximal) caries lesions in primary and/or permanent teeth (ages… · Final follow-up (1 to 7 years across trials), Resin infiltration vs non-invasive (Fig. 5, subgroup 2.1.1) Microinvasive interventions in the management of proximal caries lesions in primary and permanent teeth-… (2025) | OR 0.23 [0.15, 0.35] | 10 studies · 459 participants | Ungraded |
Resin infiltration vs CPP-ACFP Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic… Comparison of therapies of white spot lesions: a systematic review and network meta-analysis. (2023) | SMD -0.52 [-1.16, 0.12] | NR | Ungraded |
Resin infiltration vs Fluoride varnish (gold standard) Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic… Comparison of therapies of white spot lesions: a systematic review and network meta-analysis. (2023) | SMD -0.70 [-1.18, -0.21] | 4 studies | Ungraded |
Resin infiltration vs P11-4 + fluoride varnish Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic… Comparison of therapies of white spot lesions: a systematic review and network meta-analysis. (2023) | SMD 0.01 [-0.62, 0.65] | NR | Ungraded |
Resin infiltration vs Self-assembling peptide P11-4 Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic… Comparison of therapies of white spot lesions: a systematic review and network meta-analysis. (2023) | SMD -0.39 [-0.97, 0.20] | 1 study | Ungraded |
Resin infiltration vs CPP-ACP Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic… Comparison of therapies of white spot lesions: a systematic review and network meta-analysis. (2023) | SMD -0.77 [-1.31, -0.23] | 1 study | Ungraded |
Resin infiltration vs Control (placebo / no active therapy) Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic… Comparison of therapies of white spot lesions: a systematic review and network meta-analysis. (2023) | SMD -0.94 [-1.46, -0.43] | 1 study | Ungraded |
Micro-invasive treatment (resin infiltration or sealing) vs Non-invasive / control treatment Radiographic proximal caries lesion progression · Patients with non-cavitated proximal (approximal) caries lesions (primary or permanent dentition) · Longest available follow-up, Caries risk: low Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis. (2021) | OR 0.24 [0.08, 0.72] | 2 studies | Ungraded |
Resin infiltration (Icon) vs Non-invasive treatment Radiographic proximal caries lesion progression · Patients with non-cavitated proximal caries lesions · Longest available follow-up Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis. (2021) | OR 0.21 [0.15, 0.30] | 11 studies · 549 participants | Moderate |
Resin infiltration (Icon) vs Non-invasive treatment Radiographic proximal caries lesion progression · Patients with non-cavitated proximal caries lesions · Longest available follow-up, Caries risk: low Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis. (2021) | OR 0.24 [0.08, 0.72] | 2 studies | Ungraded |
Micro-invasive treatment (resin infiltration or sealing) vs Non-invasive / control treatment Radiographic proximal caries lesion progression · Patients with non-cavitated proximal (approximal) caries lesions (primary or permanent dentition) · Longest available follow-up, Caries risk: moderate to high Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis. (2021) | OR 0.17 [0.10, 0.29] | 4 studies | Ungraded |
Micro-invasive treatment (resin infiltration or sealing) vs Non-invasive / control treatment Radiographic proximal caries lesion progression · Patients with non-cavitated proximal (approximal) caries lesions (primary or permanent dentition) · Longest available follow-up, Primary dentition Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis. (2021) | OR 0.30 [0.20, 0.45] | 5 studies | Ungraded |
Resin infiltration (Icon) vs Non-invasive treatment Radiographic proximal caries lesion progression · Patients with non-cavitated proximal caries lesions · Longest available follow-up, Caries risk: moderate to high Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis. (2021) | OR 0.20 [0.10, 0.39] | 3 studies | Ungraded |
Micro-invasive treatment (resin infiltration or sealing) vs Non-invasive / control treatment Radiographic proximal caries lesion progression · Patients with non-cavitated proximal (approximal) caries lesions (primary or permanent dentition) · Longest available follow-up Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis. (2021) | OR 0.23 [0.18, 0.30] | 17 studies · 830 participants | Moderate |
Micro-invasive treatment (resin infiltration or sealing) vs Non-invasive / control treatment Radiographic proximal caries lesion progression · Patients with non-cavitated proximal (approximal) caries lesions (primary or permanent dentition) · Longest available follow-up, Caries risk: low to moderate Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis. (2021) | OR 0.38 [0.18, 0.81] | 1 study | Ungraded |
Micro-invasive treatment (resin infiltration or sealing) vs Non-invasive / control treatment Radiographic proximal caries lesion progression · Patients with non-cavitated proximal (approximal) caries lesions (primary or permanent dentition) · Longest available follow-up, Caries risk: moderate Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis. (2021) | OR 0.32 [0.01, 8.27] | 1 study | Ungraded |
Micro-invasive treatment (resin infiltration or sealing) vs Non-invasive / control treatment Radiographic proximal caries lesion progression · Patients with non-cavitated proximal (approximal) caries lesions (primary or permanent dentition) · Longest available follow-up, Caries risk: high Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis. (2021) | OR 0.14 [0.07, 0.28] | 3 studies | Ungraded |
Resin infiltration (Icon) vs Non-invasive treatment Radiographic proximal caries lesion progression · Patients with non-cavitated proximal caries lesions · Longest available follow-up, Caries risk: moderate Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis. (2021) | OR 0.32 [0.01, 8.27] | 1 study | Ungraded |
Micro-invasive treatment (resin infiltration or sealing) vs Non-invasive / control treatment Radiographic proximal caries lesion progression · Patients with non-cavitated proximal (approximal) caries lesions (primary or permanent dentition) · Longest available follow-up, Permanent dentition Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis. (2021) | OR 0.20 [0.14, 0.28] | 12 studies | Ungraded |
Micro-invasive treatment (resin infiltration or sealing) vs Non-invasive / control treatment Radiographic proximal caries lesion progression · Patients with non-cavitated proximal (approximal) caries lesions (primary or permanent dentition) · Longest available follow-up, All caries-risk levels (caries-risk subset) Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis. (2021) | OR 0.20 [0.14, 0.28] | 9 studies | Ungraded |
Resin infiltration (Icon) vs Non-invasive treatment Radiographic proximal caries lesion progression · Patients with non-cavitated proximal caries lesions · Longest available follow-up, Caries risk: high Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis. (2021) | OR 0.14 [0.05, 0.37] | 2 studies | Ungraded |
Resin infiltration (Icon) vs Non-invasive treatment Radiographic proximal caries lesion progression · Patients with non-cavitated proximal caries lesions · Longest available follow-up, Caries risk: low to moderate Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis. (2021) | OR 0.38 [0.18, 0.81] | 1 study | Ungraded |
Resin infiltration vs No treatment Arrest or reversal of noncavitated approximal carious lesions · Children and adults with noncavitated carious lesions on approximal surfaces (primary and permanent teeth) · 12-36 mo Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019) | RR 2.11 [1.08, 4.13] | 6 studies · 565 participants | Low |
Resin infiltration vs Sealant Arrest or reversal of noncavitated approximal carious lesions · Children and adults with noncavitated carious lesions on approximal surfaces (primary and permanent teeth) · 12-36 mo Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019) | RR 0.88 [0.4, 1.91] | 6 studies · 565 participants | Very low |
Resin infiltration vs Resin infiltration + 5% NaF varnish Arrest or reversal of noncavitated approximal carious lesions · Children and adults with noncavitated carious lesions on approximal surfaces (primary and permanent teeth) · 12-36 mo Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019) | RR 0.46 [0.09, 2.23] | 6 studies · 565 participants | Very low |