Gap finder

Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

79 questions in 7 reviews · cluster CL0071

current versions
No studies 0 · 0%Ungraded 62 · 78.5%Very low 11 · 13.9%Low 0 · 0%Moderate 6 · 7.6%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters

QuestionEffectEvidenceStatus / GRADE
Gingivitis vs No gingivitis
Poor oral health-related quality of life · Indians
Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023)
no estimate extracted3 studies · 943 participantsVery low
Malocclusion (occlusal disorders) vs Absence/lower severity of malocclusion
Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years)
Oral-health-related quality of life in adolescents: umbrella review. (2023)
The studies who avaliate occlusal disorders, concluded that this pathology have a negative impact on OHRQoL in adolescents.NRUngraded
Dental caries (assessed by DMFT/deft/dmft, WHO criteria or PUFA) vs Individuals without dental caries
Oral health-related quality of life (dichotomous: poor vs not) · Indians across all ages (children, adolescents, adults, elderly) · By OHRQoL scale / score direction (dichotomous)
Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023)
OR 4.73 [2.91, 7.68]7 studies · 4114 participantsUngraded
Favorable family structure (being an only child; nuclear family) vs Having siblings / non-nuclear family structure
Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years)
Oral-health-related quality of life in adolescents: umbrella review. (2023)
Being an only child, growing up in your nuclear family or family structure, household conditions, and number of people per household and maternal age are predictors of better OHRQoL [43].NRUngraded
Treatment of traumatic dental injury vs Untreated dental trauma
Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years)
Oral-health-related quality of life in adolescents: umbrella review. (2023)
Treatment of TDI reduces the negative impact on OHRQoL in adolescents, based on parental perception [33]. Treatment of traumatic dental injuries reduces the impact on the OHRQoL with low evidence [46].NRUngraded
Functional edentulism vs No functional edentulism
Poor oral health-related quality of life · Indians
Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023)
no estimate extracted2 studies · 368 participantsVery low
Functional edentulism (<20 remaining teeth) vs Individuals without functional edentulism
Oral health-related quality of life (dichotomous: poor vs not) · Indian elderly (>60 years)
Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023)
Functional edentulism vs none: studies show inconsistency; one study found a significant association (Pushpanjali 2013), one did not (Shivakumar 2018); 368 participants, 2 observational studies; Very low certainty (Fig…2 studies · 368 participantsVery low
Periodontal disease assessed by loss of attachment (LOA / clinical attachment loss) vs Individuals without periodontal disease (by LOA)
Oral health-related quality of life (continuous), measured by GOHAI · Indian adults and elderly (police, teachers, general and institutionalised populations)
Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023)
Periodontal disease (LOA) and QoL (continuous, GOHAI): one study reported a significant negative impact (Rekhi 2016), one found no significant association (Marya 2020). Not pooled.2 studiesUngraded
Functional edentulism (<20 remaining teeth) vs Individuals without functional edentulism
Oral health-related quality of life (continuous), measured by GOHAI · Indian elderly (>60 years)
Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023)
SMD 0.31 [-0.37, 0.99]4 studies · 1146 participantsVery low
Toothache / dental pain vs No dental pain
Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years)
Oral-health-related quality of life in adolescents: umbrella review. (2023)
Toothache, DMT and tooth loss have a high impact on OHRQoL in adolescentes [26]. There is low evidence that dental pain has a negative impact on OHRQoL [37].NRUngraded
Access to dental care / health services vs No / limited access to dental care
Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years)
Oral-health-related quality of life in adolescents: umbrella review. (2023)
having parents who can provide dental care and safe housing are positive predictors for OHRQoL. access to dental care and the performance of health promotion programs are directly proportional to OHRQoL in adolescents.NRUngraded
Malocclusion vs No malocclusion
Oral health-related quality of life (OHRQoL), impaired (qualitative synthesis) · Adolescents aged 10-19 years
Malocclusions and quality of life among adolescents: a systematic review and meta-analysis. (2023)
Impaired OHRQoL, qualitative synthesis: relative effect not estimable across the 13 studies (13,864 participants); moderate quality of evidence (GRADE).13 studies · 13864 participantsModerate
Periodontal disease assessed by loss of attachment (LOA / clinical attachment loss) vs Individuals without periodontal disease (by LOA)
Oral health-related quality of life (dichotomous: poor vs not) · Indian adults and elderly (police, teachers, general and institutionalised populations)
Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023)
Periodontal disease (LOA) and QoL (dichotomous): two studies found a significant association (Saxena 2018, Abhishek 2016), one denied it (Nagarajappa 2015, P=0.687). Not pooled.3 studiesUngraded
Dental caries (assessed by DMFT/deft/dmft, WHO criteria or PUFA) vs Individuals without dental caries
Oral health-related quality of life (dichotomous: poor vs not) · Indians across all ages (children, adolescents, adults, elderly)
Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023)
OR 3.54 [2.24, 5.60]10 studies · 4945 participantsModerate
Prosthetic need vs Individuals without prosthetic need
Oral health-related quality of life (continuous), measured by OHIP-14 · Indian elderly and general-population adults
Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023)
Prosthetic need and QoL (continuous, OHIP-14): prosthetic need was significantly related to various components of OHRQoL (Joseph 2016). Single study, not pooled.1 studyUngraded
Dental caries (assessed by DMFT/deft/dmft, WHO criteria or PUFA) vs Individuals without dental caries
Oral health-related quality of life (continuous), measured by OHIP-14 / ECOHIS / Michigan Oral Health QoL · Indians across all ages (children, adolescents, adults, elderly)
Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023)
SMD 0.87 [0.34, 1.40]6 studies · 4511 participantsModerate
Gingivitis (assessed by gingival index or WHO criteria) vs Individuals without gingivitis
Oral health-related quality of life (dichotomous: poor vs not) · Indians (adolescents, adults, elderly, children)
Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023)
Gingivitis vs no gingivitis: studies show inconsistency; one study showed poor QoL (Shivakumar 2018, OR 1.39, 95% CI 1.09 to 1.67), two studies no significant association (Baiju 2019, Singh 2020); 943 participants, 3…3 studies · 943 participantsVery low
Prosthetic need vs Individuals without prosthetic need
Oral health-related quality of life (continuous), measured by GOHAI · Indian elderly and general-population adults
Impact of oral conditions on oral health-related quality of life among Indians- a systematic review and… (2023)
Prosthetic need and QoL (continuous, GOHAI): of three studies, one found no significant difference (Shetty 2013) and two proved the association (Pillai 2015, Rekhi 2018). Not pooled.3 studiesUngraded
Dental (tooth) agenesis vs No dental agenesis
Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years)
Oral-health-related quality of life in adolescents: umbrella review. (2023)
tooth agenesis does not have enough scientific evidence to support a relationship between OHRQoL [41]. No articles were found that had evaluated children and adolescent. Only one was found to have a greater impact in…NRUngraded
Skin color / ethnicity vs Reference skin color / ethnicity
Oral health-related quality of life (OHRQoL) · Adolescents (10-19 years)
Oral-health-related quality of life in adolescents: umbrella review. (2023)
Biological data such as skin color and age have no concrete evidence about this impact in the OHRQoL. Important aspects like gender and skin color did not have their level of impact clarified.NRUngraded
Younger children's age (3-5 years) vs Older children (>5 years)
Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years · Age 3 years
The Association of Oral Health Status, demographic characteristics and socioeconomic determinants with Oral… (2020)
OR 2.00 [1.42, 2.57]2 studiesUngraded
All exposure-OHRQoL estimates pooled for publication-bias correction (meta-trim sensitivity); specific exposure set not defined in source vs Not specified
Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years · Trim-and-fill adjusted (publication-bias corrected), random-effects
The Association of Oral Health Status, demographic characteristics and socioeconomic determinants with Oral… (2020)
OR 0.17 [0.13, 0.21]NRUngraded
Periodontal disease (present) vs No periodontal disease
Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years
The Association of Oral Health Status, demographic characteristics and socioeconomic determinants with Oral… (2020)
OR 1.15 [1.12, 1.18]3 studiesUngraded
Female gender (girls) vs Male gender (boys)
Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years
The Association of Oral Health Status, demographic characteristics and socioeconomic determinants with Oral… (2020)
OR 1.13 [1.09, 1.17]3 studiesUngraded
Higher dental caries experience vs Caries-free children
Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years
The Association of Oral Health Status, demographic characteristics and socioeconomic determinants with Oral… (2020)
OR 1.66 [1.43, 1.88]6 studiesUngraded
Younger children's age (3-5 years) vs Older children (>5 years)
Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years · Age 4 years
The Association of Oral Health Status, demographic characteristics and socioeconomic determinants with Oral… (2020)
OR 2.13 [1.50, 2.76]2 studiesUngraded
Age 5 years vs Age older than 5 years
Poor OHRQoL · Children
The Association of Oral Health Status, demographic characteristics and socioeconomic determinants with Oral… (2020)
OR 3.68 [2.20, 5.17]1 studyUngraded
Orthodontic treatment need vs No orthodontic treatment need
Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years
The Association of Oral Health Status, demographic characteristics and socioeconomic determinants with Oral… (2020)
OR 1.13 [1.07, 1.18]3 studiesUngraded
Juvenile idiopathic arthritis (JIA) vs Children and adolescents without JIA (healthy peers)
Oral health-related quality of life (OHRQoL) · Children and adolescents with juvenile idiopathic arthritis (JIA)
Oral health in children and adolescents with juvenile idiopathic arthritis - a systematic review and… (2019)
Santos et al. [29] found oral health status had little or no effect on well-being with no significant difference between JIA and healthy groups (SF:13-B-PCPQ); Leksell et al. [38] found orofacial symptoms influenced…2 studies · 111 participantsUngraded