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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
9 questions in 3 reviews · cluster CL0038
current versionsNo studies 1 · 11.1%Ungraded 8 · 88.9%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Periodontitis vs Without periodontitis Lacunar stroke · Adults The contribution of oral infectious diseases in lacunar stroke based on meta-analysis and Mendelian… (2025) | OR 5.16 [3.68, 7.24] | 3 studies | Ungraded |
Periodontitis vs No periodontitis (periodontal health or gingivitis) Mixed-type caries (crown and root) · Adults · Mixed-type caries Association between periodontitis and dental caries: a systematic review and meta-analysis. (2024) | OR 3.40 [3.10, 3.73] | 1 study | Ungraded |
Periodontitis vs No periodontitis (periodontal health or gingivitis) Mean DFR (decayed, filled root teeth) · Adults · Overall Association between periodontitis and dental caries: a systematic review and meta-analysis. (2024) | WMD 1.13 [0.48, 1.78] | 4 studies | Ungraded |
Periodontitis vs No periodontitis (periodontal health or gingivitis) Crown caries · Adults · Crown caries Association between periodontitis and dental caries: a systematic review and meta-analysis. (2024) | OR 1.03 [1.01, 1.05] | 3 studies | Ungraded |
Gastroesophageal or laryngopharyngeal reflux (GERD/LPR) vs Healthy individuals without reflux (controls) Dental erosion (prevalence and severity) · Adults with gastroesophageal reflux disease (GERD) or laryngopharyngeal reflux (LPR) Laryngopharyngeal reflux, gastroesophageal reflux and dental disorders: A systematic review. (2020) | Controlled studies showed GERD patients have a significantly higher rate or severity of dental erosion than healthy individuals; prevalence of dental erosion in reflux patients ranged from 16% to 44% versus <20% in… | 18 studies | Ungraded |
GERD/NERD vs Healthy controls Oral mucosa inflammation · Adults Laryngopharyngeal reflux, gastroesophageal reflux and dental disorders: A systematic review. (2020) | no estimate extracted | 5 studies | Ungraded |
Gastroesophageal or laryngopharyngeal reflux (GERD/LPR) vs Healthy individuals (controls) Oral/pharyngeal microbiota modifications · Adults with GERD/LPR reflux Laryngopharyngeal reflux, gastroesophageal reflux and dental disorders: A systematic review. (2020) | no estimate extracted | 0 studies | No studies |
GERD or LPR vs Healthy controls Dental erosion · Adults Laryngopharyngeal reflux, gastroesophageal reflux and dental disorders: A systematic review. (2020) | no estimate extracted | 18 studies | Ungraded |
Surgically induced or chronic acid gastroesophageal reflux (experimental) vs Non-reflux control animals Dental erosion, alveolar bone destruction and oral/pharyngeal lesions · Rat models with surgically induced or chronic acid gastroesophageal reflux Laryngopharyngeal reflux, gastroesophageal reflux and dental disorders: A systematic review. (2020) | Two rat-model studies found significantly higher rates of dental erosion, alveolar bone destruction and osteomyelitis (Higo) and shorter molar crown heights with dentin exposure, inflammatory infiltration and fibrosis… | 2 studies | Ungraded |