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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
83 questions in 2 reviews · cluster CL0010
current versionsNo studies 0 · 0%Ungraded 83 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability Postmenopausal osteoporosis with pathological fracture · European GWAS participants · SVMR Weighted Median From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.979 [0.826, 1.159] | 281786 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS Lumbar spine and pelvis fracture · European GWAS participants · SVMR MR-Egger From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.994 [0.729, 1.355] | 490700 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability Forearm fracture · European GWAS participants · SVMR MR-Egger From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.994 [0.948, 1.042] | 490889 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability Femur fracture · European GWAS participants · SVMR MR-Egger From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.063 [0.991, 1.140] | 489106 participants | Ungraded |
Genetically predicted periodontitis vs Reference (lower genetically predicted periodontitis liability) Postmenopausal osteoporosis with pathological fracture · Postmenopausal women (European ancestry) · Lifelong genetic liability, SVMR (IVW), total causal effect From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.014 [0.857, 1.199] | 281786 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability, adjusted for DMFS Osteoporosis · European GWAS participants · MVMR MR-Egger From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.005 [0.940, 1.074] | 483725 participants | Ungraded |
Genetically predicted dental caries (DMFS index) vs Reference (1-SD lower genetically predicted DMFS) Fracture of femur · European-ancestry adults · Lifelong genetic liability, MVMR (IVW), adjusted for periodontitis From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.069 [0.923, 1.239] | 489106 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS, adjusted for periodontitis Lumbar spine and pelvis fracture · European GWAS participants · MVMR MR-Egger From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.034 [0.769, 1.390] | 490700 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability Osteoporosis with pathological fracture · European GWAS participants · SVMR MR-Egger From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.953 [0.813, 1.117] | 376746 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability Forearm fracture · European GWAS participants · SVMR Maximum Likelihood From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.990 [0.950, 1.032] | 490889 participants | Ungraded |
Genetically predicted dental caries (DMFS index) vs Reference (1-SD lower genetically predicted DMFS) Fracture of lumbar spine and pelvis · European-ancestry adults · Lifelong genetic liability, SVMR (IVW), total causal effect From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.950 [0.810, 1.113] | 490700 participants | Ungraded |
Genetically predicted dental caries (DMFS index) vs Reference (1-SD lower genetically predicted DMFS) Fracture of forearm · European-ancestry adults · Lifelong genetic liability, SVMR (IVW), total causal effect From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.921 [0.838, 1.012] | 490889 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability Postmenopausal osteoporosis with pathological fracture · European GWAS participants · SVMR Maximum Likelihood From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.014 [0.872, 1.179] | 281786 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS, adjusted for periodontitis Postmenopausal osteoporosis with pathological fracture · European GWAS participants · MVMR MR-Egger From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.281 [0.640, 2.565] | 281786 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability Osteoporosis · European GWAS participants · SVMR Maximum Likelihood From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.998 [0.934, 1.067] | 483725 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS, adjusted for periodontitis Lumbar spine bone mineral density · European GWAS participants · MVMR IVW From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | BETA 0.105 [0.011, 0.199] | 28498 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS Osteoporosis · European GWAS participants · SVMR Maximum Likelihood From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.162 [0.998, 1.353] | 483725 participants | Ungraded |
Genetically predicted periodontitis vs Reference (lower genetically predicted periodontitis liability) Postmenopausal osteoporosis with pathological fracture · Postmenopausal women (European ancestry) · Lifelong genetic liability, MVMR (IVW), adjusted for DMFS From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.016 [0.867, 1.191] | 281786 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS Forearm fracture · European GWAS participants · SVMR Weighted Median From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.914 [0.799, 1.046] | 490889 participants | Ungraded |
Genetically predicted dental caries (DMFS index) vs Reference (1-SD lower genetically predicted DMFS) Fracture of femur · European-ancestry adults · Lifelong genetic liability, SVMR (IVW), total causal effect From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.126 [0.975, 1.300] | 489106 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability Osteoporosis · European GWAS participants · SVMR Weighted Median From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.002 [0.925, 1.086] | 483725 participants | Ungraded |
Genetically predicted periodontitis vs Reference (lower genetically predicted periodontitis liability) Osteoporosis · European-ancestry adults · Lifelong genetic liability, SVMR (IVW), total causal effect From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.998 [0.933, 1.067] | 483725 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS, adjusted for periodontitis Osteoporosis with pathological fracture · European GWAS participants · MVMR MR-Egger From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.011 [0.876, 1.167] | 376746 participants | Ungraded |
Genetically predicted dental caries (DMFS index) vs Reference (1-SD lower genetically predicted DMFS) Osteoporosis · European-ancestry adults · Lifelong genetic liability, SVMR (IVW), total causal effect From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.156 [0.994, 1.343] | 483725 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS Osteoporosis · European GWAS participants · SVMR MR-Egger From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.329 [0.991, 1.782] | 483725 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability Postmenopausal osteoporosis with pathological fracture · European GWAS participants · SVMR MR-Egger From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.934 [0.786, 1.111] | 281786 participants | Ungraded |
Genetically predicted periodontitis vs Reference (lower genetically predicted periodontitis liability) Fracture of forearm · European-ancestry adults · Lifelong genetic liability, SVMR (IVW), total causal effect From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.990 [0.951, 1.031] | 490889 participants | Ungraded |
Genetically predicted dental caries (DMFS index) vs Reference (1-SD lower genetically predicted DMFS) Postmenopausal osteoporosis with pathological fracture · Postmenopausal women (European ancestry) · Lifelong genetic liability, SVMR (IVW), total causal effect From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.343 [0.948, 1.901] | 281786 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability Osteoporosis · European GWAS participants · SVMR IVW From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.998 [0.933, 1.067] | 483725 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS Osteoporosis with pathological fracture · European GWAS participants · SVMR Maximum Likelihood From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.278 [0.921, 1.773] | 376746 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability Lumbar spine and pelvis fracture · European GWAS participants · SVMR Maximum Likelihood From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.055 [0.983, 1.132] | 490700 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS Forearm fracture · European GWAS participants · SVMR MR-Egger From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.883 [0.738, 1.057] | 490889 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS Forearm fracture · European GWAS participants · SVMR Maximum Likelihood From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.920 [0.836, 1.011] | 490889 participants | Ungraded |