Gap finder
Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
83 questions in 2 reviews · cluster CL0010
current versionsNo studies 0 · 0%Ungraded 83 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS, adjusted for periodontitis Femur fracture · European GWAS participants · MVMR MR-Egger From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.820 [0.618, 1.087] | 489106 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability Lumbar spine and pelvis fracture · European GWAS participants · SVMR Weighted Median From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.058 [0.966, 1.158] | 490700 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS, adjusted for periodontitis Forearm fracture · European GWAS participants · MVMR MR-Egger From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.901 [0.751, 1.081] | 490889 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability Osteoporosis · European GWAS participants · SVMR MR-Egger From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.001 [0.918, 1.093] | 483725 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability Osteoporosis with pathological fracture · European GWAS participants · SVMR Weighted Median From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.985 [0.846, 1.146] | 376746 participants | Ungraded |
Genetically predicted dental caries (DMFS index) vs Reference (1-SD lower genetically predicted DMFS) Osteoporosis with pathological fracture · European-ancestry adults · Lifelong genetic liability, MVMR (IVW), adjusted for periodontitis From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.279 [0.955, 1.713] | 376746 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS Postmenopausal osteoporosis with pathological fracture · European GWAS participants · SVMR Maximum Likelihood From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.363 [0.955, 1.947] | 281786 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability Osteoporosis with pathological fracture · European GWAS participants · SVMR Maximum Likelihood From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.003 [0.874, 1.151] | 376746 participants | Ungraded |
Genetically predicted dental caries (DMFS index) vs Reference (1-SD lower genetically predicted DMFS) Osteoporosis · European-ancestry adults · Lifelong genetic liability, MVMR (IVW), adjusted for periodontitis From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.165 [1.020, 1.331] | 483725 participants | Ungraded |
Genetically predicted dental caries (DMFS index) vs Reference (1-SD lower genetically predicted DMFS) Forearm bone mineral density (FA-BMD) · European-ancestry adults · Lifelong genetic liability, SVMR and MVMR (IVW) From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | No causal effect of oral diseases on FA-BMD was found (SVMR and MVMR); no numeric estimate reported in text (see Fig. 3). | 8143 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability Forearm fracture · European GWAS participants · SVMR Weighted Median From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.992 [0.945, 1.042] | 490889 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS Osteoporosis with pathological fracture · European GWAS participants · SVMR MR-Egger From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.097 [0.598, 2.011] | 376746 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability, adjusted for DMFS Lumbar spine and pelvis fracture · European GWAS participants · MVMR MR-Egger From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.062 [0.991, 1.137] | 490700 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS Osteoporosis with pathological fracture · European GWAS participants · SVMR Weighted Median From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.181 [0.748, 1.866] | 376746 participants | Ungraded |
Genetically predicted dental caries (DMFS index) vs Reference (1-SD lower genetically predicted DMFS) Fracture of lumbar spine and pelvis · European-ancestry adults · Lifelong genetic liability, MVMR (IVW), adjusted for periodontitis From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.968 [0.840, 1.114] | 490700 participants | Ungraded |
Genetically predicted dental caries (DMFS index) vs Reference (1-SD lower genetically predicted DMFS) Fracture of forearm · European-ancestry adults · Lifelong genetic liability, MVMR (IVW), adjusted for periodontitis From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.973 [0.891, 1.063] | 490889 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS Femur fracture · European GWAS participants · SVMR MR-Egger From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.893 [0.678, 1.175] | 489106 participants | Ungraded |
Genetically predicted periodontitis vs Reference (lower genetically predicted periodontitis liability) Osteoporosis with pathological fracture · European-ancestry adults · Lifelong genetic liability, SVMR (IVW), total causal effect From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.003 [0.875, 1.150] | 376746 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS Lumbar spine and pelvis fracture · European GWAS participants · SVMR Weighted Median From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.867 [0.691, 1.087] | 490700 participants | Ungraded |
Genetically predicted dental caries (DMFS index) vs Reference (1-SD lower genetically predicted DMFS) Postmenopausal osteoporosis with pathological fracture · Postmenopausal women (European ancestry) · Lifelong genetic liability, MVMR (IVW), adjusted for periodontitis From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.422 [1.027, 1.969] | 281786 participants | Ungraded |
Genetically predicted periodontitis vs Without periodontitis (lower genetic liability) Lacunar stroke · European-ancestry adults (GWAS) The contribution of oral infectious diseases in lacunar stroke based on meta-analysis and Mendelian… (2025) | OR 1.24 [1.03, 1.49] | NR | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS Femur fracture · European GWAS participants · SVMR Maximum Likelihood From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.137 [0.976, 1.325] | 489106 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability, adjusted for DMFS Lumbar spine bone mineral density · European GWAS participants · MVMR IVW From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | BETA 0.047 [-0.002, 0.096] | 28498 participants | Ungraded |
Genetically predicted dental caries (DMFS index) vs Reference (1-SD lower genetically predicted DMFS) Osteoporosis with pathological fracture · European-ancestry adults · Lifelong genetic liability, SVMR (IVW), total causal effect From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.261 [0.918, 1.732] | 376746 participants | Ungraded |
Genetically predicted periodontitis vs Reference (lower genetically predicted periodontitis liability) Fracture of lumbar spine and pelvis · European-ancestry adults · Lifelong genetic liability, MVMR (IVW), adjusted for DMFS From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.060 [0.989, 1.135] | 490700 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS, adjusted for periodontitis Osteoporosis · European GWAS participants · MVMR MR-Egger From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.343 [1.015, 1.778] | 483725 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability, adjusted for DMFS Forearm fracture · European GWAS participants · MVMR MR-Egger From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.992 [0.950, 1.036] | 490889 participants | Ungraded |
Genetically predicted periodontitis vs Reference (lower genetically predicted periodontitis liability) Femoral neck bone mineral density (FN-BMD) · European-ancestry adults · Lifelong genetic liability, SVMR and MVMR (IVW) From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | No causal effect of oral diseases on FN-BMD was found (SVMR and MVMR); no numeric estimate reported in text (see Fig. 3). | 32735 participants | Ungraded |
Genetically predicted periodontitis vs Reference (lower genetically predicted periodontitis liability) Osteoporosis with pathological fracture · European-ancestry adults · Lifelong genetic liability, MVMR (IVW), adjusted for DMFS From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.003 [0.546, 1.842] | 376746 participants | Ungraded |
Genetically predicted dental caries (DMFS index) vs Reference (1-SD lower genetically predicted DMFS) Femoral neck bone mineral density (FN-BMD) · European-ancestry adults · Lifelong genetic liability, SVMR and MVMR (IVW) From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | No causal effect of oral diseases on FN-BMD was found (SVMR and MVMR); no numeric estimate reported in text (see Fig. 3). | 32735 participants | Ungraded |
Genetically predicted periodontitis vs Reference (lower genetically predicted periodontitis liability) Fracture of femur · European-ancestry adults · Lifelong genetic liability, MVMR (IVW), adjusted for DMFS From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.034 [0.963, 1.109] | 489106 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS Lumbar spine bone mineral density · European GWAS participants · SVMR IVW From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | BETA 0.105 [0.006, 0.205] | 28498 participants | Ungraded |
Genetically predicted periodontitis vs Reference (lower genetically predicted periodontitis liability) Osteoporosis · European-ancestry adults · Lifelong genetic liability, MVMR (IVW), adjusted for DMFS From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.000 [0.937, 1.067] | 483725 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability, adjusted for DMFS Femur fracture · European GWAS participants · MVMR MR-Egger From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.024 [0.960, 1.093] | 489106 participants | Ungraded |
Genetically predicted periodontitis vs Reference (lower genetically predicted periodontitis liability) Fracture of femur · European-ancestry adults · Lifelong genetic liability, SVMR (IVW), total causal effect From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.044 [0.982, 1.110] | 489106 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS Lumbar spine and pelvis fracture · European GWAS participants · SVMR Maximum Likelihood From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.950 [0.808, 1.117] | 490700 participants | Ungraded |
Genetically predicted dental caries vs Without dental caries (lower genetic liability) Lacunar stroke · European-ancestry adults (GWAS) The contribution of oral infectious diseases in lacunar stroke based on meta-analysis and Mendelian… (2025) | OR 0.92 [0.69, 1.23] | NR | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability Lumbar spine and pelvis fracture · European GWAS participants · SVMR MR-Egger From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.036 [0.956, 1.122] | 490700 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability, adjusted for DMFS Postmenopausal osteoporosis with pathological fracture · European GWAS participants · MVMR MR-Egger From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.012 [0.858, 1.193] | 281786 participants | Ungraded |
Genetically predicted periodontitis vs Reference (lower genetically predicted periodontitis liability) Fracture of lumbar spine and pelvis · European-ancestry adults · Lifelong genetic liability, SVMR (IVW), total causal effect From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.055 [0.984, 1.130] | 490700 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability, adjusted for DMFS Osteoporosis with pathological fracture · European GWAS participants · MVMR MR-Egger From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.002 [0.867, 1.158] | 376746 participants | Ungraded |
Genetically predicted periodontitis vs Reference (lower genetically predicted periodontitis liability) Forearm bone mineral density (FA-BMD) · European-ancestry adults · Lifelong genetic liability, SVMR and MVMR (IVW) From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | No causal effect of oral diseases on FA-BMD was found (SVMR and MVMR); no numeric estimate reported in text (see Fig. 3). | 8143 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS Osteoporosis · European GWAS participants · SVMR Weighted Median From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.260 [1.017, 1.560] | 483725 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS Postmenopausal osteoporosis with pathological fracture · European GWAS participants · SVMR MR-Egger From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.355 [0.696, 2.635] | 281786 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS Femur fracture · European GWAS participants · SVMR Weighted Median From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.094 [0.884, 1.354] | 489106 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability Lumbar spine bone mineral density · European GWAS participants · SVMR IVW From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | BETA 0.055 [0.008, 0.102] | 28498 participants | Ungraded |
Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS Postmenopausal osteoporosis with pathological fracture · European GWAS participants · SVMR Weighted Median From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.214 [0.746, 1.977] | 281786 participants | Ungraded |
Genetically predicted periodontitis vs Reference (lower genetically predicted periodontitis liability) Fracture of forearm · European-ancestry adults · Lifelong genetic liability, MVMR (IVW), adjusted for DMFS From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 0.995 [0.953, 1.039] | 490889 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability Femur fracture · European GWAS participants · SVMR Weighted Median From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.055 [0.979, 1.136] | 489106 participants | Ungraded |
Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability Femur fracture · European GWAS participants · SVMR Maximum Likelihood From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) | OR 1.044 [0.983, 1.109] | 489106 participants | Ungraded |