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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Population

Intervention or exposure

Comparison

Outcome

Any field or review title

Field or topic

Source

Review versions

4 questions in 3 reviews · intervention: Exposure/condition: systemic-oral · outcome domain: Microbiological/plaque

current versions

No studies 0 · 0%Ungraded 3 · 75%Very low 1 · 25%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Intervention categories, outcome domains and clusters are a proposed key pending human validation. Clear all filters

Question	Effect	Evidence	Status / GRADE
Periodontitis vs No periodontitis High salivary P. gingivalis (over 10^4 CFU/ml) · Adults · Overall Association between periodontitis and dental caries: a systematic review and meta-analysis. (2024)	OR 3.38 [1.46, 7.83]	2 studies	Ungraded
Periodontitis vs No periodontitis High salivary S. mutans (over 10^4 CFU/ml) · Adults · Overall Association between periodontitis and dental caries: a systematic review and meta-analysis. (2024)	OR 0.82 [0.44, 1.51]	2 studies	Ungraded
Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive) Salivary immunoglobulin A (SIgA) concentration · Children and adolescents (<18 years) living with HIV (CLWH) Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and… (2022)	Two studies gave divergent results: Subramaniam (2015) reported higher SIgA in children on ART for more than 3 years than pre-ART (8.6 (SD 2.9) vs 6.2 (SD 1.7) mg/dL; p < 0.001), whereas Pomarico (2009) found lower…	2 studies	Very low
Gastroesophageal or laryngopharyngeal reflux (GERD/LPR) vs Healthy individuals (controls) Salivary function impairment (buffering capacity, flow rate, oral pH) · Adults with GERD/LPR reflux Laryngopharyngeal reflux, gastroesophageal reflux and dental disorders: A systematic review. (2020)	Mixed/controversial salivary findings: reduced salivary buffering capacity supported in three studies (Correa, Holbrook, Filipi) with low oral pH and reduced flow as additional factors in GERD patients, but Meurman and Schroeder found no significant salivary abnormalities; no pooled estimate.	6 studies	Ungraded