Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,252 questions · 2,353 findings · 210 reviews · Neonatal

No studies found 432 · 18.4%GRADE not reported 99 · 4.2%Very low 609 · 25.9%Low 737 · 31.3%Moderate 385 · 16.4%High 91 · 3.9%

Vitamin A vs no supplementation

Death or chronic lung disease · promoting growth and development in very low birth weight infants receiving human milk

Supplemental vitamin A probably leads to lower death or chronic lung disease (oxygen use at 28 days) compared with no supplementation (moderate certainty).

2 findings from 1 review

Vitamin A vs no supplementation

Death before 36 weeks' postmenstrual age · promoting growth and development in very low birth weight infants receiving human milk

Supplemental vitamin A showed no clear difference in death before 36 weeks' postmenstrual age compared with no supplementation (moderate certainty).

1 finding from 1 review

Vitamin A vs no supplementation

Neurodevelopmental impairment at 18 to 22 months · promoting growth and development in very low birth weight infants receiving human milk

Supplemental vitamin A showed no clear difference in neurodevelopmental impairment at 18 to 22 months compared with no supplementation (low certainty).

1 finding from 1 review

Intervention not reported

PIPP at 30 s after heel lance Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA. A lower score = less pain (Stevens 1996) · neonates with heel lance‐associated pain
1 finding from 1 review

Intervention not reported

PIPP score Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a) · neonates with heel lance‐associated pain
1 finding from 1 review

Intervention not reported

PIPP score Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a) · neonates with heel lance‐associated pain
1 finding from 1 review

Intervention not reported

Revised NFCS Range of scale 0‐10 in term infants 0‐9 in preterm infants A lower score = less pain Grunau 1987 · neonates with pain associated with heel lance
1 finding from 1 review

Intervention not reported

Revised NFCS Range of scale 0‐10 in term infants 0‐9 in preterm infants A lower score = less pain Grunau 1987 · neonates with pain associated with heel lance
1 finding from 1 review

Intervention not reported

Revised NFCS Range of scale 0‐10 in term infants 0‐9 in preterm infants A lower score = less pain Grunau 1987 · neonates with pain associated with heel lance
1 finding from 1 review

Intervention not reported

PIPP at 60 s after heel lance Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants >3 6 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a) · neonates with heel lance‐associated pain
1 finding from 1 review

Intervention not reported

NIPS score in term and preterm infants Range of scale 0‐7 A lower score = less pain Lawrence 1993 · neonates with pain associated with venipuncture
1 finding from 1 review

Intervention not reported

PIPP score during venipuncture Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a) · neonates with pain associated with venipuncture
1 finding from 1 review

Intervention not reported

PIPP score Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a) · neonates with pain associated with venipuncture
1 finding from 1 review

Intervention not reported

PIPP score during post‐injection period Range of scale 0‐21 for infants < 28 weeks PMA and 0‐18 for infants > 36 weeks PMA A lower score = less pain (Stevens 1996; Stevens 2014a) · neonates with pain associated with venipuncture
1 finding from 1 review

Intervention not reported

DAN score during venipuncture (preterm infants) Range of scale 0‐10 A lower score = less pain (Carbajal 1997) · neonates with pain associated with venipuncture
1 finding from 1 review