Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,293 questions · 2,395 findings · 172 reviews · Gut

No studies found 420 · 17.5%GRADE not reported 60 · 2.5%Very low 821 · 34.3%Low 602 · 25.1%Moderate 397 · 16.6%High 95 · 4%

Intervention not reported

Overall survival Hazard ratio · patients with resectable thoracic esophageal cancer

The intervention probably leads to lower overall survival Hazard ratio (moderate certainty).

1 finding from 1 review

Intervention not reported

Complete resection (R0) Histology · patients with resectable thoracic esophageal cancer

The intervention probably leads to higher complete resection (R0) Histology (moderate certainty).

1 finding from 1 review

Intervention not reported

Local‐regional recurrence Radiology · patients with resectable thoracic esophageal cancer

The intervention showed no clear difference in local‐regional recurrence Radiology (moderate certainty).

1 finding from 1 review

Intervention not reported

Distant recurrence Radiology · patients with resectable thoracic esophageal cancer

The intervention showed no clear difference in distant recurrence Radiology (moderate certainty).

1 finding from 1 review

Intervention not reported

Any complication Clinical · patients with resectable thoracic esophageal cancer

The intervention showed no clear difference in any complication Clinical (moderate certainty).

1 finding from 1 review

Intervention not reported

Postoperative death Clinical · patients with resectable thoracic esophageal cancer

The intervention showed no clear difference in postoperative death Clinical (low certainty).

1 finding from 1 review

Intervention not reported

Anastomotic leaks Clinical/radiology · patients with resectable thoracic esophageal cancer

The intervention showed no clear difference in anastomotic leaks Clinical/radiology (moderate certainty).

1 finding from 1 review

Intervention not reported

Overall survival (surviving rates) · patients with resectable disease

The intervention showed no clear difference in overall survival (surviving rates) (low certainty).

1 finding from 1 review

Intervention not reported

Disease specific survival (surviving rates) · patients with resectable disease

The intervention probably leads to lower disease specific survival (surviving rates) (moderate certainty).

1 finding from 1 review

Intervention not reported

Disease free survival (surviving rates) · patients with resectable disease

The intervention showed no clear difference in disease free survival (surviving rates) (moderate certainty).

1 finding from 1 review

Intervention not reported

Postoperative mortality (within 30 days from surgery) · patients with resectable disease

The intervention leads to higher postoperative mortality (within 30 days from surgery) (high certainty).

1 finding from 1 review

Laparoscopic fundoplication vs medical management

Serious adverse events · Patients with gastro‐oesophageal reflux disease (GORD) in adults

It is very uncertain whether laparoscopic fundoplication changes serious adverse events compared with medical management (very low certainty).

1 finding from 1 review

Laparoscopic fundoplication vs medical management

(5 years or more) · Patients with gastro‐oesophageal reflux disease (GORD) in adults

It is very uncertain whether laparoscopic fundoplication changes (5 years or more) compared with medical management (very low certainty).

1 finding from 1 review