Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,119 questions · 2,206 findings · 117 reviews · Common Mental Disorders

No studies found 387 · 17.5%GRADE not reported 111 · 5%Very low 635 · 28.8%Low 568 · 25.7%Moderate 449 · 20.4%High 56 · 2.5%

Antidepressant plus antipsychotic vs placebo plus antidepressant

Clinical response of depression · adults with psychotic depression

It is very uncertain whether antidepressant plus antipsychotic changes clinical response of depression compared with placebo plus antidepressant (very low certainty).

2 findings from 1 review

Antidepressant plus antipsychotic vs placebo plus antidepressant

Leaving the study early · adults with psychotic depression

It is very uncertain whether antidepressant plus antipsychotic changes overall dropouts compared with placebo plus antidepressant (very low certainty).

2 findings from 1 review

Antidepressant plus antipsychotic vs placebo plus antidepressant

Change in depression severity from baseline · adults with psychotic depression

The review found no eligible studies for this question.

2 findings from 1 review

Antidepressant plus antipsychotic vs placebo plus antidepressant

Acceptability ‐ dropouts due to adverse effects · adults with psychotic depression

The review found no eligible studies for this question.

2 findings from 1 review