Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,252 questions · 2,353 findings · 210 reviews · Neonatal

No studies found 432 · 18.4%GRADE not reported 99 · 4.2%Very low 609 · 25.9%Low 737 · 31.3%Moderate 385 · 16.4%High 91 · 3.9%

Volume‐targeted vs pressure‐limited ventilation: additional findings

Respiratory acidosis pH < 7.25 and pCO2 > 60 mmHg/8 kPa · neonates up to 44 weeks' postmenstrual age

Volume‐targeted showed no clear difference in respiratory acidosis pH < 7.25 and pCO2 > 60 mmHg/8 kPa compared with pressure‐limited ventilation: additional findings (low certainty).

1 finding from 1 review

Volume‐targeted vs pressure‐limited ventilation: additional findings

Either hypocarbia or respiratory acidosis · neonates up to 44 weeks' postmenstrual age

Volume‐targeted showed no clear difference in either hypocarbia or respiratory acidosis compared with pressure‐limited ventilation: additional findings; GRADE not reported.

1 finding from 1 review

Volume‐targeted vs pressure‐limited ventilation: additional findings

BPD or death at 36 weeks' postmenstrual age№ of participants: 0 (0 RCTs) · neonates up to 44 weeks' postmenstrual age

Volume‐targeted probably leads to lower death or BPD (36 weeks) compared with pressure‐limited ventilation: main findings (moderate certainty).

1 finding from 1 review

Volume‐targeted vs pressure‐limited ventilation: additional findings

Severe (grade 3 or greater) intraventricular hemorrhage (IVH) on cranial ultrasound ‐ not reported · neonates up to 44 weeks' postmenstrual age

Volume‐targeted probably leads to lower IVH grade 3‐4 compared with pressure‐limited ventilation: main findings (moderate certainty).

1 finding from 1 review