Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,510 questions · 2,653 findings · 194 reviews · Gynaecology and Fertility

No studies found 531 · 20%GRADE not reported 76 · 2.9%Very low 826 · 31.1%Low 855 · 32.2%Moderate 341 · 12.9%High 24 · 0.9%

Recombinant luteinizing hormone (rLH) combined with recombinant follicle‐stimulating hormone (rFSH) vs rFSH alone

Live birth rate · Women undergoing ovarian stimulation with gonadotrophins in IVF and ICSI procedures

It is very uncertain whether recombinant luteinizing hormone (rLH) combined with recombinant… changes live birth rate compared with rFSH alone (very low certainty).

1 finding from 1 review

Recombinant luteinizing hormone (rLH) combined with recombinant follicle‐stimulating hormone (rFSH) vs rFSH alone

OHSS · Women undergoing ovarian stimulation with gonadotrophins in IVF and ICSI procedures

Recombinant luteinizing hormone (rLH) combined with recombinant… showed no clear difference in OHSS incidence compared with rFSH alone (low certainty).

1 finding from 1 review

Recombinant luteinizing hormone (rLH) combined with recombinant follicle‐stimulating hormone (rFSH) vs rFSH alone

Ongoing pregnancy · Women undergoing ovarian stimulation with gonadotrophins in IVF and ICSI procedures

Recombinant luteinizing hormone (rLH) combined with recombinant… probably leads to higher ongoing pregnancy rate compared with rFSH alone (moderate certainty).

1 finding from 1 review

Recombinant luteinizing hormone (rLH) combined with recombinant follicle‐stimulating hormone (rFSH) vs rFSH alone

Miscarriage · Women undergoing ovarian stimulation with gonadotrophins in IVF and ICSI procedures

Recombinant luteinizing hormone (rLH) combined with recombinant… showed no clear difference in miscarriage rate compared with rFSH alone (moderate certainty).

1 finding from 1 review

Recombinant luteinizing hormone (rLH) combined with recombinant follicle‐stimulating hormone (rFSH) vs rFSH alone

Cancellation rate for low response · Women undergoing ovarian stimulation with gonadotrophins in IVF and ICSI procedures

Recombinant luteinizing hormone (rLH) combined with recombinant… showed no clear difference in cancellation rate for low response compared with rFSH alone (low certainty).

1 finding from 1 review

Recombinant luteinizing hormone (rLH) combined with recombinant follicle‐stimulating hormone (rFSH) vs rFSH alone

Cancellation rate for imminent OHSS · Women undergoing ovarian stimulation with gonadotrophins in IVF and ICSI procedures

It is very uncertain whether recombinant luteinizing hormone (rLH) combined with recombinant… changes cancellation rate for imminent OHSS compared with rFSH alone (very low certainty).

1 finding from 1 review

Combined oral contraceptive pill vs no pretreatment

Live birth or ongoing pregnancy · women undergoing assisted reproduction

Combined oral contraceptive pill probably leads to lower live birth or ongoing pregnancy (COCP + Ant vs Ant) compared with no pretreatment (moderate certainty).

2 findings from 1 review

Summary of findings table ‐ Progestogens vs placebo or no pretreatment

Live birth or ongoing pregnancy · ovarian stimulation protocols for women undergoing ART

Progestogen showed no clear difference in live birth or ongoing pregnancy (Prog + Ant vs Ant) compared with placebo or no pretreatment (low certainty).

2 findings from 1 review

Summary of findings table ‐ Progestogens vs placebo or no pretreatment

Pregnancy loss · ovarian stimulation protocols for women undergoing ART

Progestogen showed no clear difference in pregnancy loss (Prog + Ag vs Ag) compared with placebo or no pretreatment (low certainty).

2 findings from 1 review

Summary of findings table ‐ Progestogens vs placebo or no pretreatment

Multiple pregnancy rate · ovarian stimulation protocols for women undergoing ART

The review found no eligible studies for this question.

2 findings from 1 review

Summary of findings table ‐ Progestogens vs placebo or no pretreatment

OHSS · ovarian stimulation protocols for women undergoing ART

The review found no eligible studies for this question.

2 findings from 1 review

Oestrogen vs no pretreatment

Live birth or ongoing pregnancy · ovarian stimulation protocols for women undergoing ART

Oestrogen showed no clear difference in live birth or ongoing pregnancy (Oestr + Ant vs Ant) compared with no pretreatment (moderate certainty).

2 findings from 1 review

Oestrogen vs no pretreatment

Pregnancy loss · ovarian stimulation protocols for women undergoing ART

It is very uncertain whether oestrogen changes pregnancy loss (Oestr + Ant vs Ant) compared with no pretreatment (very low certainty).

2 findings from 1 review

Oestrogen vs no pretreatment

Multiple pregnancy rate · ovarian stimulation protocols for women undergoing ART

The review found no eligible studies for this question.

2 findings from 1 review