Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,923 questions · 1,956 findings · 143 reviews · Musculoskeletal

No studies found 555 · 28.4%GRADE not reported 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%

Febuxostat 80 mg/day vs placebo

Acute gout attacks · people with chronic gout

Febuxostat 80 mg/day showed no clear difference in incidence of gout flares compared with placebo (low certainty).

1 finding from 1 review

Febuxostat 80 mg/day vs placebo

Serum uric acid <6.0 mg/dL at final visit · people with chronic gout

Febuxostat 80 mg/day may leads to higher serum uric acid <6.0 mg/dL at final visit compared with placebo (low certainty).

1 finding from 1 review

Muscle relaxant vs control

Total Number of Adverse Events ‐ only studies >24hrs duration · patients with pain management in rheumatoid arthritis

It is very uncertain whether muscle relaxant changes total Number of Adverse Events ‐ only studies >24hrs duration compared with control (very low certainty).

1 finding from 1 review

Muscle relaxant vs control

Total Number of Adverse Events ‐ single dose studies · patients with pain management in rheumatoid arthritis

It is very uncertain whether muscle relaxant changes total Number of Adverse Events ‐ single dose studies compared with control (very low certainty).

1 finding from 1 review