Cochrane · systematic review · CD009807
Monoamine oxidase inhibitors (MAOIs) for fibromyalgia syndrome
Tort, S, Urrútia, G, Nishishinya, MB, et al. · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
MusculoskeletalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
5
No studies
2
Included studies
NR
No studies 2 · 28.6%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 71.4%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
MAOIs compared to placebo for fibromyalgia syndrome
Population: patients with fibromyalgia syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain (VAS) VAS from: 0 to 10 MAOIs vs placebo | no estimate extracted | 2 studies · 121 participants | Low Downgraded: risk of bias, imprecision |
Tender points Tender point score and number of tender points MAOIs vs placebo | no estimate extracted | 2 studies · 121 participants | Low Downgraded: risk of bias, imprecision |
Global assessment (by patient) VAS from: 0 to 10 MAOIs vs placebo | no estimate extracted | 2 studies · 121 participants | Low Downgraded: risk of bias, imprecision |
Physical function MAOIs vs placebo | no estimate extracted | NR | No studies |
Discontinuation due to adverse events MAOIs vs placebo | no estimate extracted | 2 studies · 149 participants | Low Downgraded: risk of bias, imprecision |
Adverse events (nausea and vomiting) MAOIs vs placebo | no estimate extracted | 1 study · 89 participants | Low Downgraded: risk of bias, imprecision |
Sleep disturbance MAOIs vs placebo | no estimate extracted | NR | No studies |