Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,252 questions · 2,353 findings · 210 reviews · Neonatal

No studies found 432 · 18.4%GRADE not reported 99 · 4.2%Very low 609 · 25.9%Low 737 · 31.3%Moderate 385 · 16.4%High 91 · 3.9%

Antibiotics on removal of central venous catheter vs no antibiotics

Central line‐associated blood stream infection · newborn infants undergoing removal of central venous catheter

Antibiotics on removal of central venous catheter showed no clear difference in central line‐associated blood stream infection compared with no antibiotics (low certainty).

1 finding from 1 review

Respiratory support vs no respiratory support before cord clamping

Mortality ≤2 years after hospital discharge · preterm infants

Respiratory support showed no clear difference in mortality ≤2 years after hospital discharge compared with no respiratory support before cord clamping (low certainty).

1 finding from 1 review

Respiratory support vs no respiratory support before cord clamping

Blood transfusion during neonatal admission · preterm infants

Respiratory support showed no clear difference in blood transfusion during neonatal admission compared with no respiratory support before cord clamping (moderate certainty).

1 finding from 1 review

Respiratory support vs no respiratory support before cord clamping

Severe intraventricular haemorrhage · preterm infants

It is very uncertain whether respiratory support changes severe intraventricular haemorrhage grade 3 or 4 compared with no respiratory support before cord clamping (very low certainty).

1 finding from 1 review

Probiotics administered to pregnant women at risk of preterm birth vs placebo or no intervention

Gestational age (preterm birth < 37 weeks) · preterm infants

Probiotics administered to pregnant women at risk of preterm birth showed no clear difference in preterm birth < 37 weeks' gestation compared with placebo or no intervention (low certainty).

1 finding from 1 review

Probiotics administered exclusively after birth in mothers of preterm infants vs placebo or no intervention

Necrotising enterocolitis · preterm infants

Probiotics administered exclusively after birth in mothers of… showed no clear difference in any necrotizing Enterocolitis (NEC) compared with maternal placebo or no intervention (low certainty).

1 finding from 1 review

Probiotics administered exclusively after birth in mothers of preterm infants vs placebo or no intervention

Mortality before hospital discharge · preterm infants

Probiotics administered exclusively after birth in mothers of… showed no clear difference in death prior to hospital discharge compared with maternal placebo or no intervention (low certainty).

1 finding from 1 review

Probiotics administered exclusively after birth in mothers of preterm infants vs placebo or no intervention

Death or NEC · preterm infants

Probiotics administered exclusively after birth in mothers of… showed no clear difference in death or NEC compared with maternal placebo or no intervention (low certainty).

1 finding from 1 review

Probiotics administered exclusively after birth in mothers of preterm infants vs placebo or no intervention

NEC‐related surgery during study period · preterm infants

Probiotics administered exclusively after birth in mothers of… showed no clear difference in surgery for NEC compared with maternal placebo or no intervention (low certainty).

1 finding from 1 review

Probiotics administered exclusively after birth in mothers of preterm infants vs placebo or no intervention

Neonatal sepsis · preterm infants

Probiotics administered exclusively after birth in mothers of… showed no clear difference in neonatal sepsis compared with maternal placebo or no intervention (low certainty).

1 finding from 1 review