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Evidence found and GRADE certainty

4,860 questions · 64,864 findings · 4,913 reviews · Headline outcomes only

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No studies found 13,869 · 21.4%GRADE not reported 3,491 · 5.4%Very low 16,300 · 25.1%Low 17,338 · 26.7%Moderate 10,900 · 16.8%High 2,966 · 4.6%

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Summary of findings table ‐ Vitamin B12 supplementation vs no supplementation or placebo

Maternal anaemia · pregnant women

It is very uncertain whether summary of findings table ‐ Vitamin B12 supplementation changes maternal anaemia compared with placebo/no vitamin B12 supplementation (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Vitamin B12 supplementation vs no supplementation or placebo

Maternal vitamin B12 deficiency · pregnant women

It is very uncertain whether summary of findings table ‐ Vitamin B12 supplementation changes maternal vitamin B12 deficiency compared with placebo/no vitamin B12 supplementation (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Vitamin B12 supplementation vs no supplementation or placebo

Low birthweight · pregnant women

Summary of findings table ‐ Vitamin B12 supplementation showed no clear difference in low birthweight (< 2500 g) compared with placebo/no vitamin B12 supplementation (low certainty).

1 finding from 1 review

Summary of findings table ‐ Vitamin B12 supplementation vs no supplementation or placebo

Preterm birth · pregnant women

Summary of findings table ‐ Vitamin B12 supplementation showed no clear difference in preterm birth (< 37 weeks) compared with placebo/no vitamin B12 supplementation (low certainty).

1 finding from 1 review

Intrauterine infusion of autologous platelet‐rich plasma vs no intervention

Live birth or ongoing pregnancy · women undergoing assisted reproduction

It is very uncertain whether intrauterine injection of autologous platelet‐rich plasma changes live birth (or ongoing pregnancy) compared with no intervention (very low certainty).

1 finding from 1 review

Intrauterine infusion/injection of autologous platelet‐rich plasma vs placebo or no intervention

Adverse events: preterm delivery · women undergoing assisted reproduction

Intrauterine infusion/injection of autologous platelet‐rich plasma may leads to higher adverse events: preterm delivery compared with no intervention or placebo (low certainty).

1 finding from 1 review

Intrauterine infusion of autologous platelet‐rich plasma vs intrauterine infusion of granulocyte colony‐stimulating factor

Live birth or ongoing pregnancy · women undergoing assisted reproduction

It is very uncertain whether intrauterine infusion of autologous platelet‐rich plasma changes live birth (or ongoing pregnancy compared with intrauterine infusion of granulocyte colony‐stimulating factor (very low certainty).

1 finding from 1 review

Intrauterine infusion of autologous platelet‐rich plasma vs intrauterine infusion of granulocyte colony‐stimulating factor

Miscarriage · women undergoing assisted reproduction

It is very uncertain whether intrauterine infusion of autologous platelet‐rich plasma changes miscarriage compared with intrauterine infusion of granulocyte colony‐stimulating factor (very low certainty).

1 finding from 1 review

Intrauterine infusion of autologous platelet‐rich plasma vs intrauterine infusion of granulocyte colony‐stimulating factor

Clinical pregnancy · women undergoing assisted reproduction

It is very uncertain whether intrauterine infusion of autologous platelet‐rich plasma changes clinical pregnancy compared with intrauterine infusion of granulocyte colony‐stimulating factor (very low certainty).

1 finding from 1 review

Intrauterine infusion of autologous platelet‐rich plasma vs no intervention

Adverse events: ectopic pregnancy · women undergoing assisted reproduction

It is very uncertain whether intrauterine injection of autologous platelet‐rich plasma changes adverse events: ectopic pregnancy compared with no intervention (very low certainty).

1 finding from 1 review