Findings

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Evidence found and GRADE certainty

762 questions · 830 findings · 43 reviews · Orthodontics

No studies found 186 · 22.4%GRADE not reported 410 · 49.4%Very low 122 · 14.7%Low 79 · 9.5%Moderate 30 · 3.6%High 3 · 0.4%

Coated superelastic NiTi wire (BioCosmetic, Titanol, TP Aesthetic or Tooth Tone) vs A different coated superelastic NiTi wire

Alignment rate · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
1 finding from 1 review

Multistrand stainless steel wire vs Wires of other materials (conventional stainless steel, superelastic NiTi, thermoelastic NiTi)

Alignment rate · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
1 finding from 1 review
  • Initial arch wires used in orthodontic treatment with fixed appliances 2024 · Cochrane All outcomes
    6 weeks to 6 months
    Multistrand StSt versus other materials (conventional StSt, superelastic NiTi, thermoelastic NiTi); alignment rate not pooled due to clinical heterogeneity (Cobb 1998; Evans 1998; Quintao 2005; West 1995); results…
    4 studies · 281 participants
    Very low

Facemask with rapid maxillary expansion (RME) vs Reverse Twin Block with lip pads and rapid maxillary expander (RME)

Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Facemask with rapid maxillary expansion (RME) led to lower wits appraisal compared with reverse Twin Block with lip pads and rapid maxillary expander (RME); GRADE not reported.

1 finding from 1 review

Facemask (RME) or modified facemask vs Surgically-anchored appliance (miniscrews or miniplates)

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Facemask (RME) or modified facemask showed no clear difference in ANB compared with surgically-anchored appliance (miniscrews or miniplates) (low certainty).

1 finding from 1 review

Adhesive flash-free ceramic brackets vs Adhesive precoated ceramic brackets

Enamel demineralization (QLF ΔF) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

Flash-free brackets showed no clinical WSL reduction, with certainty not graded.

1 finding from 1 review

Clearfil Protect Bond antibacterial fluoride-releasing primer vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control

White spot lesion rate and volume · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

Clearfil Protect Bond showed no WSL-rate difference versus conventional adhesive, with certainty not graded.

1 finding from 1 review

Transbond XT with 1% chitosan and 1% TiO2 nanoparticles vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control

Enamel mineral content · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

Chitosan and TiO2 adhesive showed no enamel mineral-content difference, with certainty not graded.

1 finding from 1 review

Experimental adhesive containing ammonium-based methacrylate monomer (MADQUAT) vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control

Enamel remineralization / carious lesion development · Human enamel specimens around orthodontic brackets (in vitro)

In vitro, an ammonium-based methacrylate-containing adhesive showed significant remineralization/anti-demineralization versus control in a single study (ungraded).

1 finding from 1 review

Hybrid Hyrax (RME) with miniscrews and Class III elastics vs Conventional Hyrax (RME) with miniscrews and Class III elastics

Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Hybrid Hyrax (RME) with miniscrews and Class III elastics showed no clear difference in wits appraisal compared with conventional Hyrax (RME) with miniscrews and Class III elastics; GRADE not reported.

1 finding from 1 review

Facemask (with frame internal fixation) vs Frankel III functional appliance

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Facemask (with frame internal fixation) showed no clear difference in ANB compared with frankel III functional appliance; GRADE not reported.

1 finding from 1 review

Facemask (RME) or modified facemask vs Other non-surgical orthodontic treatments (mini maxillary protractor, Pushing Splints, modified tandem, Reverse Forsus, reverse Twin Block, reverse chin cup, tongue appliance, Frankel III)

Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

It is very uncertain whether facemask (RME) or modified facemask changes overjet compared with other non-surgical orthodontic treatments (mini maxillary… (very low certainty).

1 finding from 1 review

Indirect bonding using flowable composite adhesive (Opal Bond MV) vs Direct bonding (conventional, Transbond XT)

White spot lesion formation (QLF: fluorescence loss, lesion area) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)

A single RCT found indirect bonding with flowable composite reduced white spot lesion formation versus direct bonding (ungraded).

1 finding from 1 review

Bone-anchored intermaxillary traction (BAIMT) vs Removable mandibular retractor (RMR)

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Bone-anchored intermaxillary traction (BAIMT) led to higher ANB compared with removable mandibular retractor (RMR); GRADE not reported.

1 finding from 1 review

Hybrid Hyrax (RME) with miniscrews and Class III elastics vs Conventional Hyrax (RME) with miniscrews and Class III elastics

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Hybrid Hyrax (RME) with miniscrews and Class III elastics showed no clear difference in ANB compared with conventional Hyrax (RME) with miniscrews and Class III elastics; GRADE not reported.

1 finding from 1 review

Fixed orthodontic treatment with fixed (multibracket) appliances (exposure) vs None (single-group prevalence/incidence estimate)

Incidence of new ICLs (proportion of subjects developing new lesions) · Patients undergoing fixed orthodontic treatment with fixed (multibracket) appliances, followed for development of new ICLs

About 48% of patients developed new ICLs during fixed orthodontic treatment (pooled incidence 0.48, 95% CI 0.33-0.63; very low certainty; very high heterogeneity).

1 finding from 1 review

Fixed orthodontic treatment with fixed (multibracket) appliances (exposure) vs None (single-group prevalence/incidence estimate)

Prevalence of ICLs (proportion of tooth surfaces affected) · Patients (permanent dentition) during or after fixed orthodontic treatment with fixed (multibracket) appliances

About 22% of tooth surfaces showed ICLs during/after fixed orthodontic treatment (pooled 0.22, 95% CI 0.14-0.33; very low certainty; extreme heterogeneity).

1 finding from 1 review