Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

671 questions · 731 findings · 61 reviews · Drugs and Alcohol

No studies found 57 · 7.8%GRADE not reported 39 · 5.3%Very low 186 · 25.4%Low 239 · 32.7%Moderate 171 · 23.4%High 39 · 5.3%

Dihydrocodeine vs buprenorphine

Abstinence · individuals dependent on illicit opiates

Dihydrocodeine showed no clear difference in abstinence Assessed by urinalysis post‐detoxification compared with buprenorphine (low certainty).

3 findings from 1 review

Alcoholics Anonymous (AA)/Twelve‐Step Facilitation (TSF) (manualized) vs other clinical interventions

Abstinence · adults (> 18 years) with alcohol use disorder, alcohol abuse, or alcohol dependence

Alcoholics Anonymous (AA)/Twelve‐Step Facilitation (TSF) (manualized) leads to higher abstinence compared with other clinical interventions (high certainty).

2 findings from 1 review

Alcoholics Anonymous (AA)/Twelve‐Step Facilitation (TSF) (non‐manualized) vs a different type of TSF

Abstinence · adults (> 18 years) with alcohol use disorder, alcohol abuse, or alcohol dependence

Alcoholics Anonymous (AA)/Twelve‐Step Facilitation (TSF)… probably leads to higher abstinence compared with a different type of TSF (moderate certainty).

2 findings from 1 review

Alcoholics Anonymous (AA)/Twelve‐Step Facilitation (TSF) (non‐manualized) vs a different type of TSF

Drinking Intensity · adults (> 18 years) with alcohol use disorder, alcohol abuse, or alcohol dependence

The review found no eligible studies for this question.

2 findings from 1 review

Alcoholics Anonymous (AA)/Twelve‐Step Facilitation (TSF) (non‐manualized) vs a different type of TSF

Alcohol‐related consequences · adults (> 18 years) with alcohol use disorder, alcohol abuse, or alcohol dependence

The review found no eligible studies for this question.

2 findings from 1 review

Alcoholics Anonymous (AA)/Twelve‐Step Facilitation (TSF) (non‐manualized) vs a different type of TSF

Addiction Severity Index alcohol score · adults (> 18 years) with alcohol use disorder, alcohol abuse, or alcohol dependence

The review found no eligible studies for this question.

2 findings from 1 review