Findings

What do systematic reviews say?

2,119 questions · 2,206 findings · 117 reviews · Common Mental Disorders

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No studies found 387 · 17.5%GRADE not reported 111 · 5%Very low 635 · 28.8%Low 568 · 25.7%Moderate 449 · 20.4%High 56 · 2.5%

Selective serotonin reuptake inhibitors vs SNRIs

Leaving the study early · adults with panic disorder

SSRIs showed no clear difference in total number of dropouts compared with SNRIs (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.11 [0.74, 1.65]
2 studies · 991 participants
Low

Selective serotonin reuptake inhibitors vs SNRIs

Failure to remit at endpoint · adults with panic disorder

SSRIs showed no clear difference in failure to remit compared with SNRIs (high certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.05 [0.91, 1.21]
2 studies · 991 participants
High

Selective serotonin reuptake inhibitors vs SNRIs

panic symptoms · adults with panic disorder

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 945 participants
High

Selective serotonin reuptake inhibitors vs SNRIs

Withdrawals due to adverse events · adults with panic disorder

SSRIs showed no clear difference in number of dropouts due to adverse effects compared with SNRIs (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.86 [0.49, 7.05]
2 studies · 991 participants
Low

Selective serotonin reuptake inhibitors vs NaSSAs

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Selective serotonin reuptake inhibitors vs NaSSAs

Leaving the study early · adults with panic disorder

SSRIs showed no clear difference in total number of dropouts compared with naSSAs (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.5 [0.29, 7.73]
1 study · 30 participants
Low

Antidepressants vs benzodiazepines

panic symptoms · adults with panic disorder

2 findings from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1144 participants
Very low
Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Low

Selective serotonin reuptake inhibitors vs NaSSAs

Failure to remit at endpoint · adults with panic disorder

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Selective serotonin reuptake inhibitors vs NaSSAs

panic symptoms · adults with panic disorder

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 22 participants
Low

Selective serotonin reuptake inhibitors vs NaSSAs

Withdrawals due to adverse events · adults with panic disorder

SSRIs showed no clear difference in number of dropouts due to adverse events compared with naSSAs (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.5 [0.29, 7.73]
1 study · 30 participants
Low

Antidepressants vs benzodiazepines

Withdrawals due to adverse events · adults with panic disorder

Antidepressants may leads to higher number of dropouts due to adverse effects compared with benzodiazepines (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.72 [1.03, 2.87]
3 studies · 1002 participants
Low

Tricyclic antidepressants vs benzodiazepines

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

It is very uncertain whether TCAs changes failure to respond compared with benzodiazepines (very low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.02 [0.63, 1.67]
1 study · 61 participants
Very low

Tricyclic antidepressants vs benzodiazepines

Leaving the study early · adults with panic disorder

It is very uncertain whether TCAs changes total number of dropouts compared with benzodiazepines (very low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.67 [0.93, 2.99]
6 studies · 1295 participants
Very low

Tricyclic antidepressants vs benzodiazepines

Failure to remit at endpoint · adults with panic disorder

TCAs showed no clear difference in failure to remit compared with benzodiazepines (moderate certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.19 [1, 1.41]
2 studies · 848 participants
Moderate

Comparison 1: CBT‐based psychotherapy vs treatment

Repetition of SH at post‐intervention · adults who engage in SH

Comparison 1: CBT‐based psychotherapy showed no clear difference in repetition of SH at post‐intervention compared with treatment (low certainty).

1 finding from 1 review

Psychosocial interventions for self‐harm in adults 2016 · Cochrane Headline outcomes only
OR 0.66 [0.36, 1.21]
1 study · 313 participants
Low

Comparison 2: Interventions for multiple repetition of SH/probable personality disorder vs treatment

DBT vs TAU · adults who engage in SH

The review found no eligible studies for this question.

1 finding from 1 review

Psychosocial interventions for self‐harm in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Comparison 2: Interventions for multiple repetition of SH/probable personality disorder vs treatment

Repetition of SH at 12 months · adults who engage in SH

Comparison 2: Interventions for multiple repetition of SH/probable… showed no clear difference in repetition of SH at 12 months' compared with treatment (low certainty).

2 findings from 1 review

Psychosocial interventions for self‐harm in adults 2016 · Cochrane Headline outcomes only
OR 0.36 [0.05, 2.47]
2 studies · 172 participants
Low
Psychosocial interventions for self‐harm in adults 2016 · Cochrane Headline outcomes only
OR 1.18 [0.35, 3.95]
1 study · 97 participants
Very low

Comparison 2: Interventions for multiple repetition of SH/probable personality disorder vs treatment

Repetition of SH at final · adults who engage in SH

Comparison 2: Interventions for multiple repetition of SH/probable… showed no clear difference in repetition of SH at final compared with treatment (low certainty).

1 finding from 1 review

Psychosocial interventions for self‐harm in adults 2016 · Cochrane Headline outcomes only
OR 0.57 [0.21, 1.59]
3 studies · 247 participants
Low

Comparison 2: Interventions for multiple repetition of SH/probable personality disorder vs treatment

Repetition of SH at 6 months' · adults who engage in SH

Comparison 2: Interventions for multiple repetition of SH/probable… showed no clear difference in repetition of SH at 6 months' compared with treatment (low certainty).

1 finding from 1 review

Psychosocial interventions for self‐harm in adults 2016 · Cochrane Headline outcomes only
OR 0.67 [0.08, 5.68]
1 study · 18 participants
Low

Comparison 2: Interventions for multiple repetition of SH/probable personality disorder vs treatment

Frequency of SH at 12 months · adults who engage in SH

1 finding from 1 review

Psychosocial interventions for self‐harm in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Low