> 50% reduction in depressive symptoms · depression in adults
S‐adenosyl methionine as monotherapy showed no clear difference in proportions of participants responding to treatment ≥ 50% reduction… compared with SSRI antidepressant agent (low certainty).
1 finding from 1 review
Depression remission · depression in adults
S‐adenosyl methionine as monotherapy showed no clear difference in proportions of participants achieving remission depression rating… compared with SSRI antidepressant agent (low certainty).
1 finding from 1 review
Acceptability. Participants experiencing troublesome adverse effects of any nature · depression in adults
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Change in depressive symptoms · depression in adults
1 finding from 1 review
Secondary outcome: acceptability of treatment · depression in adults
It is very uncertain whether S‐adenosyl methionine as adjunctive treatment changes acceptability Participants dropping out of treatment during the… compared with placebo (very low certainty).
1 finding from 1 review
Proportions of participants responding to treatment ≥ 50% reduction in depression score from baseline to end of treatment. A larger RR indicates greater response to treatment in the SAMe group · depression in adults
S‐adenosyl methionine as adjunctive treatment may leads to higher proportions of participants responding to treatment ≥ 50% reduction… compared with placebo (low certainty).
1 finding from 1 review
Depression remission · depression in adults
S‐adenosyl methionine as adjunctive treatment may leads to higher proportions of participants achieving remission depression rating… compared with placebo (low certainty).
1 finding from 1 review
Secondary outcome: acceptability of treatment · depression in adults
S‐adenosyl methionine as monotherapy showed no clear difference in acceptability Participants dropping out of treatment during the… compared with placebo (low certainty).
1 finding from 1 review
Acceptability. Participants experiencing troublesome adverse effects of any nature · depression in adults
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
> 50% reduction in depressive symptoms · depression in adults
S‐adenosyl methionine as monotherapy showed no clear difference in proportions of participants responding to treatment ≥ 50% reduction… compared with placebo (low certainty).
1 finding from 1 review
Depression remission · depression in adults
S‐adenosyl methionine as monotherapy showed no clear difference in proportions of participants achieving remission Depression rating… compared with placebo (low certainty).
1 finding from 1 review
Acceptability. Participants experiencing troublesome adverse effects of any nature · depression in adults
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Change in depressive symptoms · depression in adults
1 finding from 1 review
Secondary outcome: acceptability of treatment · depression in adults
It is very uncertain whether S‐adenosyl methionine as monotherapy changes acceptability Participants dropping out of treatment during the… compared with tricyclic antidepressant agent (very low certainty).
1 finding from 1 review
> 50% reduction in depressive symptoms · depression in adults
It is very uncertain whether S‐adenosyl methionine as monotherapy changes proportions of participants responding to treatment ≥ 50% reduction… compared with tricyclic antidepressant agent (very low certainty).
1 finding from 1 review
Depression remission · depression in adults
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Clinically important improvement in anxiety at post‐treatment Indexed by a standardized interview or clinically accepted measure cut‐off score1 · patients with anxiety disorders
Therapist‐supported ICBT may leads to higher clinically important improvement in anxiety at post‐treatment… compared with waiting list, attention, information, or online discussion group… (low certainty).
1 finding from 1 review
Quality of life at post‐treatment Indexed by self‐report measures of quality of life or functional disability · patients with anxiety disorders
1 finding from 1 review
Adverse events at post‐treatment not reported · patients with anxiety disorders
1 finding from 1 review
Participant satisfaction Indexed by a mix of qualitative and quantitative self‐report measures · patients with anxiety disorders
1 finding from 1 review