Acceptability: total withdrawals · Patients receiving methotrexate for rheumatoid arthritis
Folinic acid probably leads to lower total withdrawals compared with placebo (moderate certainty).
1 finding from 1 review
Stomatitis / mouth sores (incidence) · Patients receiving methotrexate for rheumatoid arthritis
Folic or folinic acid (any) showed no clear difference in stomatitis / mouth sores (incidence) compared with placebo (moderate certainty).
1 finding from 1 review
Number of swollen joints with folinic acid (≤7 mg/wk) Change in number of swollen joints · Patients receiving methotrexate for rheumatoid arthritis
1 finding from 1 review
Number of tender joints with folinic acid (≤7 mg/wk) Change in number of tender joints · Patients receiving methotrexate for rheumatoid arthritis
1 finding from 1 review
Liver toxicity (incidence of transaminase elevation) · Patients receiving methotrexate for rheumatoid arthritis
Folic or folinic acid (any) probably leads to lower liver toxicity (incidence of transaminase elevation) compared with placebo (moderate certainty).
1 finding from 1 review
Haematological disorders (neutropenia, etc) · Patients receiving methotrexate for rheumatoid arthritis
Folic or folinic acid (any) showed no clear difference in haematological disorders (neutropenia, etc) compared with placebo (low certainty).
1 finding from 1 review
Acceptability: total withdrawals · Patients receiving methotrexate for rheumatoid arthritis
Folic or folinic acid (any) probably leads to lower total withdrawals compared with placebo (moderate certainty).
1 finding from 1 review
Swollen joints Number of swollen joints Scale from 0 to 28 · Patients receiving methotrexate for rheumatoid arthritis
1 finding from 1 review
Number of tender joints Change in number of tender joints · Patients receiving methotrexate for rheumatoid arthritis
1 finding from 1 review
GI side effects (ie, incidence of nausea, vomiting, abdominal pain) · Patients receiving methotrexate for rheumatoid arthritis
Folic acid showed no clear difference in GI side effects (ie, incidence of nausea, vomiting, abdominal pain) compared with placebo (moderate certainty).
1 finding from 1 review
Stomatitis / mouth sores (incidence) · Patients receiving methotrexate for rheumatoid arthritis
Folic acid showed no clear difference in stomatitis / mouth sores (incidence) compared with placebo (moderate certainty).
1 finding from 1 review
Response to treatment (20% improvement)* · patients with neuropsychiatric involvement in systemic lupus erythematosus
It is very uncertain whether cyclophosphamide changes response to treatment (20% improvement)* compared with methylprednisolone (very low certainty).
1 finding from 1 review
Urinary tract infection · patients with neuropsychiatric involvement in systemic lupus erythematosus
It is very uncertain whether cyclophosphamide changes adverse events ‐ Urinary tract infections compared with methylprednisolone (very low certainty).
1 finding from 1 review
Adverse events ‐ Death · patients with neuropsychiatric involvement in systemic lupus erythematosus
It is very uncertain whether cyclophosphamide changes adverse events ‐ Death compared with methylprednisolone (very low certainty).
1 finding from 1 review
SLICC scores (damage index) Scale: from 0 to 48 (lower is better) · patients with neuropsychiatric involvement in systemic lupus erythematosus
1 finding from 1 review
Disease activity · patients with neuropsychiatric involvement in systemic lupus erythematosus
1 finding from 1 review
Prednisone sparing · patients with neuropsychiatric involvement in systemic lupus erythematosus
1 finding from 1 review
Seizures · patients with neuropsychiatric involvement in systemic lupus erythematosus
It is very uncertain whether cyclophosphamide changes seizures compared with methylprednisolone (very low certainty).
1 finding from 1 review
Pain VAS 0‐100 (higher means worse) · patients with osteoarthritis
1 finding from 1 review
Function (short‐term) WOMAC scale from: 0 to 100 (higher is worse function). · patients with osteoarthritis
1 finding from 1 review