Muscle pain at rest · People with temporomandibular disorders (TMD)
It is very uncertain whether occlusal splint changes muscle pain at rest compared with physical therapy (ultrasound, exercise, sensorimotor training,… (very low certainty).
1 finding from 1 review
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
It is very uncertain whether tongue depressor stretches (physiotherapy) changes maximal mouth opening (interincisal distance) compared with intralesional steroid plus hyaluronidase injections (very low certainty).
1 finding from 1 review
Rotation of the mandibular second permanent molar · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
After mandibular first molar extraction, the second molar was rotated in about 77% of cases (2 studies; very imprecise; not GRADE-rated).
1 finding from 1 review
Caries presence in primary teeth · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age
It is very uncertain whether prophylaxis (teeth cleaning) and CHX or iodine-NaF solution… changes caries presence in primary teeth compared with placebo (very low certainty).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Mature permanent teeth with irreversible pulpitis and carious pulp exposure (treated with full pulpotomy)
Platelet-rich fibrin and calcium hydroxide showed no significant difference in success (ungraded; effect size not reported).
1 finding from 1 review
Aesthetics · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Streptococcus mutans count · Children and/or adolescents (<18 years) without background systemic disease
Probiotics probably reduce Streptococcus mutans count versus control (MD -0.40 CFU/mL, 95%CI -0.57 to -0.24; moderate certainty).
1 finding from 1 review
Bacterial growth inhibition · Streptococcus mutans (in vitro cultures and biofilms)
Grape seed extract inhibits S. mutans growth in vitro (MIC ~0.5 mg/mL to 250 mg/mL across 5 studies; ungraded).
1 finding from 1 review
GSE inhibited S. mutans growth across ~0.5-250 mg/mL (Abstract): inhibition at 250-500 mg/mL (Swadas), 4 mg/mL (Zhao), MIC 1000 ug/mL and MBC 4000 ug/mL (Furiga), MIC 0.5 mg/mL (Smullen), and MIC 19.07 mg/mL for…
5 studies
GRADE not reported
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
In the mandible, extraction at Demirjian stage E (vs later F-H) increases odds of space closure (OR 3.81; low certainty).
1 finding from 1 review
Pocket closure · Adults (> 18 years) with peri-implant mucositis, receiving active treatment
The review found no eligible studies for this question.
1 finding from 1 review
Dental caries · Adults from Japanese and European cohorts (present-study Japanese direct-to-consumer cohort + GLIDE consortium and UK Biobank European…
Meta-analysis identified a novel genome-wide-significant locus for dental caries at rs10974056 in GLIS3 (P=3.93E-08); ungraded.
1 finding from 1 review
Patient satisfaction · Adults (> 18 years) with recurrent periodontitis, receiving supportive (maintenance) periodontal care
The review found no eligible studies for this question.
1 finding from 1 review
Severity of joint noise · People with temporomandibular disorders (TMD)
The review found no eligible studies for this question.
1 finding from 1 review
Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
One study found space closure more likely with crowding than spacing (OR 5.9; single study; not GRADE-rated).
1 finding from 1 review
Difficulty in mouth opening (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
Antioxidants (lycopene, curcumin, Oxitard) led to lower difficulty in mouth opening (participant-reported proxy) compared with placebo or no active treatment; GRADE not reported.
1 finding from 1 review
Dental pain or sensitivity · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
1 finding from 1 review
Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years
It is very uncertain whether started toothbrushing with fluoride toothpaste before 12 months… changes fluorosis (percentage prevalence in permanent teeth) compared with started after 12 months (later start) (very low certainty).
1 finding from 1 review
Serum 25-hydroxyvitamin D level · Children aged 6 years or younger (preschool children)
Children with severe ECC had significantly lower serum 25(OH)D than caries-free children (WMD -18.64 nmol/l; ungraded).
1 finding from 1 review
Dental caries prevalence · Institutionalized orphan children (roughly 3 to 18 years)
Institutionalized orphan children may be at higher risk of dental caries than parented children (pooled RR 1.19), but the estimate is imprecise and not statistically significant (very low certainty).
1 finding from 1 review
Caries arrest · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
2 findings from 1 review