Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,494 questions · 1,521 findings · 132 reviews · Hepato-Biliary

No studies found 303 · 19.9%GRADE not reported 39 · 2.6%Very low 876 · 57.6%Low 216 · 14.2%Moderate 65 · 4.3%High 22 · 1.4%

Intervention not reported

All‐cause mortality or liver‐related morbidity · patients with chronic hepatitis C

It is very uncertain whether the intervention changes all‐cause mortality or liver‐related morbidity (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events · patients with chronic hepatitis C

The intervention showed no clear difference in adverse events (moderate certainty).

1 finding from 1 review

Intervention not reported

Failure of end of treatment virological response Absence of clearance of HCV RNA from the blood at end of treatment · patients with chronic hepatitis C

The intervention showed no clear difference in failure of end of treatment virological response Absence of… (moderate certainty).

1 finding from 1 review

Intervention not reported

Failure of sustained virological response Absence of clearance of HCV RNA from the blood 6 months after treatment · patients with chronic hepatitis C

The intervention showed no clear difference in failure of sustained virological response Absence of clearance of… (moderate certainty).

1 finding from 1 review

Intervention not reported

Quality of life Different QoL scales · patients with chronic hepatitis C
1 finding from 1 review

Intervention not reported

Failure of normalisation of ALT at end of treatment · patients with chronic hepatitis C

The intervention may leads to lower failure of normalisation of ALT at end of treatment (low certainty).

1 finding from 1 review

Intervention not reported

Failure of normalisation of ALT at end of · patients with chronic hepatitis C

The intervention showed no clear difference in failure of normalisation of ALT at end of (low certainty).

1 finding from 1 review

T‐cell antibody induction vs corticosteroid induction

Infection Number of participants who experienced at least 1 episode of infection · liver transplant recipients

T‐cell antibody induction showed no clear difference in infection Number of participants who experienced at least 1 episode… compared with corticosteroid induction (low certainty).

1 finding from 1 review

T‐cell antibody induction vs corticosteroid induction

Hepatitis C recurrence Number of participants diagnosed with hepatitis C virus recurrence · liver transplant recipients

T‐cell antibody induction showed no clear difference in hepatitis C recurrence Number of participants diagnosed with… compared with corticosteroid induction (low certainty).

1 finding from 1 review

T‐cell antibody induction vs placebo or no intervention

Graft loss including death · liver transplant recipients

T‐cell antibody induction may leads to lower graft loss including death Graft loss including death at latest compared with placebo/no intervention (low certainty).

1 finding from 1 review

T‐cell antibody induction vs placebo or no intervention

Acute rejection · liver transplant recipients

T‐cell antibody induction probably leads to lower acute rejection Number of participants who experienced at least 1… compared with placebo/no intervention (moderate certainty).

1 finding from 1 review