Findings

What do systematic reviews say?

1,139 questions · 1,173 findings · 89 reviews · Neuromuscular

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No studies found 302 · 25.7%GRADE not reported 119 · 10.1%Very low 267 · 22.8%Low 239 · 20.4%Moderate 177 · 15.1%High 69 · 5.9%

Strengthening exercise vs no exercise

Change in maximal isometric voluntary contraction force (Nm) · patients with people with peripheral neuropathy

1 finding from 1 review

Exercise for people with peripheral neuropathy 2004 · Cochrane Headline outcomes only
no estimate extracted
1 study · 26 participants
Moderate

Lower limb strengthening and balance exercise vs upper limb strengthening exercise

% Change in activities specific balance confidence scale scores ABC scale. Scale from: 0 to 100. · patients with people with peripheral neuropathy

1 finding from 1 review

Exercise for people with peripheral neuropathy 2004 · Cochrane Headline outcomes only
no estimate extracted
1 study · 16 participants
Moderate

Home‐based exercise therapy vs no exercise

Change in average muscle scores AMS. Scale from: 0 to 10. · patients with people with peripheral neuropathy

1 finding from 1 review

Exercise for people with peripheral neuropathy 2004 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
Moderate

Home‐based exercise therapy vs no exercise

Change in left handgrip force (Kg) · patients with people with peripheral neuropathy

1 finding from 1 review

Exercise for people with peripheral neuropathy 2004 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
Moderate

Home‐based exercise therapy vs no exercise

Change in right handgrip force (Kg) · patients with people with peripheral neuropathy

1 finding from 1 review

Exercise for people with peripheral neuropathy 2004 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
Moderate

Any CNTF vs placebo

Deaths · patients with the treatment of amyotrophic lateral sclerosis or motor neuron disease

Any CNTF showed no clear difference in deaths compared with placebo (high certainty).

1 finding from 1 review

Ciliary neurotrophic factor (CNTF) for amyotrophic lateral sclerosis or motor neuron disease 2004 · Cochrane Headline outcomes only
RR 1.07 [0.81, 1.41]
2 studies · 1300 participants
High

Any CNTF vs placebo

Muscle strength · patients with the treatment of amyotrophic lateral sclerosis or motor neuron disease

1 finding from 1 review

Ciliary neurotrophic factor (CNTF) for amyotrophic lateral sclerosis or motor neuron disease 2004 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1300 participants
High

Any CNTF vs placebo

FVC (% predicted) Change from baseline · patients with the treatment of amyotrophic lateral sclerosis or motor neuron disease

1 finding from 1 review

Ciliary neurotrophic factor (CNTF) for amyotrophic lateral sclerosis or motor neuron disease 2004 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1300 participants
High

Changes in quality of life (SIP) change in Sickness Impact Profile (SIP) scores (range from 0 = best health to 100 = worst health). · patients with the treatment of amyotrophic lateral sclerosis or motor neuron disease

1 finding from 1 review

Ciliary neurotrophic factor (CNTF) for amyotrophic lateral sclerosis or motor neuron disease 2004 · Cochrane Headline outcomes only
no estimate extracted
1 study · 503 participants
High

Any CNTF vs placebo

Asthenia · patients with the treatment of amyotrophic lateral sclerosis or motor neuron disease

Any CNTF showed no clear difference in asthenia compared with placebo (high certainty).

1 finding from 1 review

Ciliary neurotrophic factor (CNTF) for amyotrophic lateral sclerosis or motor neuron disease 2004 · Cochrane Headline outcomes only
RR 1.02 [0.81, 1.28]
1 study · 570 participants
High

Any CNTF vs placebo

Nausea · patients with the treatment of amyotrophic lateral sclerosis or motor neuron disease

Any CNTF showed no clear difference in nausea compared with placebo (high certainty).

1 finding from 1 review

Ciliary neurotrophic factor (CNTF) for amyotrophic lateral sclerosis or motor neuron disease 2004 · Cochrane Headline outcomes only
RR 1.35 [0.92, 1.99]
1 study · 570 participants
High

Any CNTF vs placebo

Increased salivation · patients with the treatment of amyotrophic lateral sclerosis or motor neuron disease

Any CNTF showed no clear difference in increased salivation compared with placebo (high certainty).

1 finding from 1 review

Ciliary neurotrophic factor (CNTF) for amyotrophic lateral sclerosis or motor neuron disease 2004 · Cochrane Headline outcomes only
RR 1.08 [0.78, 1.5]
1 study · 570 participants
High

Prednisone vs prednisone and plasma exchange (Gajdos 1983)

Score (MMS) day 30

1 finding from 1 review

Plasma exchange for generalised myasthenia gravis 2002 · Cochrane Headline outcomes only
no estimate extracted
1 study · 14 participants
Low

Prednisone vs prednisone and plasma exchange (Gajdos 1983)

Score (MMS) month 12

1 finding from 1 review

Plasma exchange for generalised myasthenia gravis 2002 · Cochrane Headline outcomes only
no estimate extracted
1 study · 14 participants
Low

IVIg vs plasma exchange

Week 1

1 finding from 1 review

Plasma exchange for generalised myasthenia gravis 2002 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Very low

IVIg vs plasma exchange

Week 4

1 finding from 1 review

Plasma exchange for generalised myasthenia gravis 2002 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
Very low

PE vs intravenous immunoglobulin (IVIG)

Change in score (MMS) day 0 to day 15

1 finding from 1 review

Plasma exchange for generalised myasthenia gravis 2002 · Cochrane Headline outcomes only
no estimate extracted
1 study · 87 participants
High

PE vs no plasma exchange before thymectomy (Kamel 2009)

Duration of MV (days)

1 finding from 1 review

Plasma exchange for generalised myasthenia gravis 2002 · Cochrane Headline outcomes only
no estimate extracted
1 study · 45 participants
Low

PE vs no plasma exchange before thymectomy (Kamel 2009)

Duration of ICU stay

1 finding from 1 review

Plasma exchange for generalised myasthenia gravis 2002 · Cochrane Headline outcomes only
no estimate extracted
1 study · 45 participants
Low