Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,495 questions · 1,554 findings · 140 reviews · Heart

No studies found 272 · 17.5%GRADE not reported 44 · 2.8%Very low 329 · 21.2%Low 464 · 29.9%Moderate 319 · 20.5%High 126 · 8.1%

Oxygen vs air

All‐cause mortality in hospital for participants with AMI · patients with acute myocardial infarction

It is very uncertain whether oxygen changes all‐cause mortality in hospital for participants with AMI compared with air (very low certainty).

1 finding from 1 review

Oxygen vs air

All‐cause mortality in hospital for all participants (including those without confirmed AMI) · patients with acute myocardial infarction

It is very uncertain whether oxygen changes all‐cause mortality in hospital for all participants (including… compared with air (very low certainty).

1 finding from 1 review

Oxygen vs air

All‐cause mortality in hospital for all participants (including those without confirmed AMI) trials done in the revascularisation era · patients with acute myocardial infarction

Oxygen showed no clear difference in all‐cause mortality in hospital for all participants (including… compared with air (low certainty).

1 finding from 1 review

Oxygen vs air

Opiate use (as a proxy measure for pain) for all participants on ITT (including those without confirmed AMI) · patients with acute myocardial infarction

Oxygen showed no clear difference in opiate use (as a proxy measure for pain) for all participants on ITT… compared with air (low certainty).

1 finding from 1 review

Oxygen vs air

Recurrent myocardial infarction (or ischaemia) · patients with acute myocardial infarction

Oxygen showed no clear difference in recurrent myocardial infarction (or ischaemia) compared with air (low certainty).

1 finding from 1 review

Intervention not reported

Mortality (all cause) Long‐term · people with chronic ischaemic heart disease and congestive heart failure

The intervention may leads to lower mortality (all cause) Long‐term (low certainty).

1 finding from 1 review

Intervention not reported

Non‐fatal myocardial infarction Long‐term · people with chronic ischaemic heart disease and congestive heart failure

The intervention may leads to lower non‐fatal myocardial infarction Long‐term (low certainty).

1 finding from 1 review

Intervention not reported

Rehospitalisation due to heart failure Long‐term · people with chronic ischaemic heart disease and congestive heart failure

The intervention showed no clear difference in rehospitalisation due to heart failure Long‐term (low certainty).

1 finding from 1 review

Intervention not reported

Composite MACE Long‐term · people with chronic ischaemic heart disease and congestive heart failure

The intervention showed no clear difference in composite MACE Long‐term (low certainty).

1 finding from 1 review

Does treatment guided by serial BNP or NT‐proBNP monitoring improve outcomes vs treatment guided by clinical assessment alone?

All‐cause mortality · patients with heart failure

Does treatment guided by serial BNP or NT‐proBNP monitoring improve… showed no clear difference in all‐cause mortality compared with treatment guided by clinical assessment alone? (low certainty).

1 finding from 1 review

Does treatment guided by serial BNP or NT‐proBNP monitoring improve outcomes vs treatment guided by clinical assessment alone?

Heart failure mortality · patients with heart failure

Does treatment guided by serial BNP or NT‐proBNP monitoring improve… showed no clear difference in heart failure mortality compared with treatment guided by clinical assessment alone? (low certainty).

1 finding from 1 review

Does treatment guided by serial BNP or NT‐proBNP monitoring improve outcomes vs treatment guided by clinical assessment alone?

Heart failure hospitalisation (RR) · patients with heart failure

Does treatment guided by serial BNP or NT‐proBNP monitoring improve… may leads to lower heart failure admissions compared with treatment guided by clinical assessment alone? (low certainty).

1 finding from 1 review

Does treatment guided by serial BNP or NT‐proBNP monitoring improve outcomes vs treatment guided by clinical assessment alone?

Hospital admissions · patients with heart failure

Does treatment guided by serial BNP or NT‐proBNP monitoring improve… showed no clear difference in all‐cause admissions compared with treatment guided by clinical assessment alone? (low certainty).

1 finding from 1 review