Cochrane · systematic review · CD008966
B‐type natriuretic peptide‐guided treatment for heart failure
McLellan, J, Heneghan, CJ, Perera, R, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
HeartAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 6 · 85.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Does treatment guided by serial BNP or NT‐proBNP monitoring improve outcomes compared to treatment guided by clinical assessment alone?
Population: patients with heart failure
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Does treatment guided by serial BNP or NT‐proBNP monitoring improve outcomes vs treatment guided by clinical assessment alone? | RR 0.87 [0.76, 1.01] | 15 studies · 3169 participants | Low Downgraded: risk of bias, imprecision |
Heart failure mortality Does treatment guided by serial BNP or NT‐proBNP monitoring improve outcomes vs treatment guided by clinical assessment alone? | RR 0.84 [0.54, 1.3] | 6 studies · 853 participants | Low Downgraded: risk of bias, imprecision |
Heart failure admissions Does treatment guided by serial BNP or NT‐proBNP monitoring improve outcomes vs treatment guided by clinical assessment alone? | RR 0.7 [0.61, 0.8] | 10 studies · 1928 participants | Low Downgraded: risk of bias, inconsistency |
All‐cause admissions Does treatment guided by serial BNP or NT‐proBNP monitoring improve outcomes vs treatment guided by clinical assessment alone? | RR 0.93 [0.84, 1.03] | 6 studies · 1142 participants | Low Downgraded: risk of bias, imprecision |
Adverse events Does treatment guided by serial BNP or NT‐proBNP monitoring improve outcomes vs treatment guided by clinical assessment alone? | no estimate extracted | 6 studies · 1144 participants | Low Downgraded: risk of bias |
Cost Does treatment guided by serial BNP or NT‐proBNP monitoring improve outcomes vs treatment guided by clinical assessment alone? | no estimate extracted | 4 studies · 1051 participants | Low Downgraded: risk of bias |
Quality of life Scale from: 0 to 105. Does treatment guided by serial BNP or NT‐proBNP monitoring improve outcomes vs treatment guided by clinical assessment alone? | no estimate extracted | 8 studies · 1812 participants | Very low Downgraded: risk of bias, inconsistency |