Findings

What do systematic reviews say?

1,562 questions · 1,645 findings · 107 reviews · Wounds

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No studies found 651 · 39.6%GRADE not reported 84 · 5.1%Very low 554 · 33.7%Low 283 · 17.2%Moderate 64 · 3.9%High 9 · 0.5%

Topical phenytoin vs simple dressing

Adverse events · people with pressure ulcers

1 finding from 1 review

Topical phenytoin for treating pressure ulcers 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 81 participants
GRADE not reported

Topical phenytoin vs simple dressing

Pain · people with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Topical phenytoin for treating pressure ulcers 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical phenytoin vs hydrocolloid dressing

The proportion of pressure ulcers healed · people with pressure ulcers

Topical phenytoin may leads to lower proportion of ulcers healed within trial period (eight weeks) compared with hydrocolloid dressing (low certainty).

1 finding from 1 review

Topical phenytoin for treating pressure ulcers 2017 · Cochrane Headline outcomes only
RR 0.55 [0.33, 0.92]
1 study · 56 participants
Low

Topical phenytoin vs hydrocolloid dressing

Adverse events · people with pressure ulcers

1 finding from 1 review

Topical phenytoin for treating pressure ulcers 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 84 participants
GRADE not reported

Topical phenytoin vs hydrocolloid dressing

Pain · people with pressure ulcers

1 finding from 1 review

Topical phenytoin for treating pressure ulcers 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
GRADE not reported

Topical phenytoin vs triple antibiotic ointment

Time to complete healing · people with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Topical phenytoin for treating pressure ulcers 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical phenytoin vs triple antibiotic ointment

The proportion of pressure ulcers healed · people with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Topical phenytoin for treating pressure ulcers 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical phenytoin vs triple antibiotic ointment

Adverse events · people with pressure ulcers

1 finding from 1 review

Topical phenytoin for treating pressure ulcers 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
GRADE not reported

Topical phenytoin vs triple antibiotic ointment

Pain · people with pressure ulcers

1 finding from 1 review

Topical phenytoin for treating pressure ulcers 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 28 participants
GRADE not reported

Topical phenytoin vs simple dressing

Time to complete healing · people with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Topical phenytoin for treating pressure ulcers 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antimicrobial dressings vs non‐antimicrobial dressings

Proportion of wounds healed · people with diabetes and foot ulcers

Antimicrobial dressings may leads to higher proportion of wounds healed Up to 24 weeks' compared with non‐antimicrobial dressings (low certainty).

1 finding from 1 review

Topical antimicrobial agents for treating foot ulcers in people with diabetes 2017 · Cochrane Headline outcomes only
RR 1.28 [1.12, 1.45]
5 studies · 945 participants
Low

Topical antimicrobial agent vs an alternative topical antimicrobial agent

Incidence of infection Up to 24 weeks' · people with diabetes and foot ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Topical antimicrobial agents for treating foot ulcers in people with diabetes 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical antimicrobial agent vs an alternative topical antimicrobial agent

Resolution of infection · people with diabetes and foot ulcers

It is very uncertain whether one topical antimicrobial agent changes resolution of infection Up to 24 weeks' compared with an alternative topical antimicrobial agent (very low certainty).

1 finding from 1 review

Topical antimicrobial agents for treating foot ulcers in people with diabetes 2017 · Cochrane Headline outcomes only
RR 1.45 [0.97, 2.17]
1 study · 37 participants
Very low

Topical antimicrobial agent vs an alternative topical antimicrobial agent

Adverse events Up to 24 weeks' · people with diabetes and foot ulcers

1 finding from 1 review

Topical antimicrobial agents for treating foot ulcers in people with diabetes 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 41 participants
Very low

Topical antimicrobial agent vs systemic antimicrobial agent

Proportion of wounds healed · people with diabetes and foot ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Topical antimicrobial agents for treating foot ulcers in people with diabetes 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical antimicrobial agent vs systemic antimicrobial agent

Incidence of infection · people with diabetes and foot ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Topical antimicrobial agents for treating foot ulcers in people with diabetes 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical antimicrobial agent vs systemic antimicrobial agent

Resolution of infection · people with diabetes and foot ulcers

It is very uncertain whether topical antimicrobial agent changes resolution of infection compared with systemic antimicrobial agent (very low certainty).

1 finding from 1 review

Topical antimicrobial agents for treating foot ulcers in people with diabetes 2017 · Cochrane Headline outcomes only
RR 1.51 [0.91, 2.49]
2 studies · 102 participants
Very low

Topical antimicrobial agent vs systemic antimicrobial agent

Adverse events · people with diabetes and foot ulcers

Topical antimicrobial agent showed no clear difference in adverse events compared with systemic antimicrobial agent (moderate certainty).

1 finding from 1 review

Topical antimicrobial agents for treating foot ulcers in people with diabetes 2017 · Cochrane Headline outcomes only
RR 0.91 [0.78, 1.06]
4 studies · 937 participants
Moderate

Topical antimicrobial agent vs growth factor

Proportion of wounds healed · people with diabetes and foot ulcers

It is very uncertain whether topical antimicrobial agent changes proportion of wounds healed compared with growth factor (very low certainty).

1 finding from 1 review

Topical antimicrobial agents for treating foot ulcers in people with diabetes 2017 · Cochrane Headline outcomes only
RR 0.5 [0.28, 0.89]
1 study · 40 participants
Very low

Topical antimicrobial agent vs growth factor

Incidence of infection · people with diabetes and foot ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Topical antimicrobial agents for treating foot ulcers in people with diabetes 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found