Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,187 questions · 1,248 findings · 108 reviews · Stroke

No studies found 275 · 22%GRADE not reported 56 · 4.5%Very low 269 · 21.6%Low 349 · 28%Moderate 216 · 17.3%High 83 · 6.7%

Systemic antispasticity drugs vs placebo

Indirect measure of spasticity Modified Ashworth Scale · people with spasticity following stroke

It is very uncertain whether systemic antispasticity drugs changes indirect measure of spasticity Modified Ashworth Scale compared with placebo (very low certainty).

1 finding from 1 review

Self‐management interventions vs usual care

Quality of life Change scores/post intervention SF‐12 or ‐36: physical or mental functioning EuroQol; SAQoL; SSQoL · people with stroke

Self management programmes showed no clear difference in quality of life Change scores/post intervention SF‐12 or ‐36:… compared with usual care (low certainty).

1 finding from 1 review

Very early cerebral revascularization vs delayed treatment

Perioperative death and strokes · people with recently symptomatic carotid artery stenosis

It is very uncertain whether very early cerebral revascularization changes stroke and Death < 30 days compared with delayed treatment (very low certainty).

2 findings from 1 review

Intervention not reported

Fatigue severity at the end of pharmacological treatment (assessed by different fatigue scales) · people with stroke with fatigue

It is very uncertain whether the intervention changes fatigue severity at the end of pharmacological treatment (assessed… (very low certainty).

1 finding from 1 review