What do systematic reviews say?

Intervention not reported

The intervention showed no clear difference in serum/plasma creatinine levels (μmol/L) (low certainty).

• Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  11 studies · 918 participants
  Low

Intervention not reported

The intervention showed no clear difference in failure to close a patent ductus arteriosus (PDA) (after 3 doses) (low certainty).

• Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants 2020 · Cochrane Headline outcomes only
  RR 0.96 [0.73, 1.27]
  8 studies · 272 participants
  Low

High protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 114 participants
  Low

Very high protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

The review found no eligible studies for this question.

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Very high protein vs high protein intake (restricted to studies meeting all a priori inclusion criteria)

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 77 participants
  Moderate

Very high protein vs high protein intake (restricted to studies meeting all a priori inclusion criteria)

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 77 participants
  Moderate

Very high protein vs high protein intake (restricted to studies meeting all a priori inclusion criteria)

The review found no eligible studies for this question.

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Very high protein vs high protein intake (restricted to studies meeting all a priori inclusion criteria)

The review found no eligible studies for this question.

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Very high protein vs high protein intake (restricted to studies meeting all a priori inclusion criteria)

The review found no eligible studies for this question.

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

High protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 48 participants
  Low

High protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 18 participants
  Very low

High protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

The review found no eligible studies for this question.

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

High protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 46 participants
  Low

Very high protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

The review found no eligible studies for this question.

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Very high protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

The review found no eligible studies for this question.

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Very high protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

The review found no eligible studies for this question.

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Very high protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

The review found no eligible studies for this question.

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The intervention probably leads to lower presence of PDA on third to fourth day of life (after 72 hours of… (moderate certainty).

• Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants 2020 · Cochrane Headline outcomes only
  RR 0.39 [0.31, 0.48]
  9 studies · 1029 participants
  Moderate

Intervention not reported

• Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 827 participants
  High

Intervention not reported

The intervention probably leads to lower need for surgical closure of PDA (during hospital stay) (moderate certainty).

• Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants 2020 · Cochrane Headline outcomes only
  RR 0.46 [0.22, 0.96]
  7 studies · 925 participants
  Moderate