Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,494 questions · 1,521 findings · 132 reviews · Hepato-Biliary

No studies found 303 · 19.9%GRADE not reported 39 · 2.6%Very low 876 · 57.6%Low 216 · 14.2%Moderate 65 · 4.3%High 22 · 1.4%

Peginterferon plus ribavirin vs non‐pegylated interferon plus ribavirin

Discontinuation of medication due to adverse events · people with chronic hepatitis C

Peginterferon plus ribavirin showed no clear difference in adverse events leading to treatment discontinuation compared with non‐pegylated interferon plus ribavirin (low certainty).

1 finding from 1 review

Peginterferon plus ribavirin vs non‐pegylated interferon plus ribavirin

Sustained virological response · people with chronic hepatitis C

It is very uncertain whether peginterferon plus ribavirin changes sustained virological response compared with non‐pegylated interferon plus ribavirin (very low certainty).

1 finding from 1 review

Peginterferon alpha‐2a vs peginterferon alpha‐2b

All‐cause mortality Deaths during and after the treatment · people with chronic hepatitis C

It is very uncertain whether peginterferon alpha‐2a changes all‐cause mortality Deaths during and after the treatment compared with peginterferon alpha‐2b (very low certainty).

1 finding from 1 review

Peginterferon alpha‐2a vs peginterferon alpha‐2b

Discontinuation of medication due to adverse events · people with chronic hepatitis C

Peginterferon alpha‐2a showed no clear difference in adverse events leading to treatment discontinuation Number of events compared with peginterferon alpha‐2b (low certainty).

1 finding from 1 review

Intervention vs control

Selective bowel decontamination versus inactive control · people undergoing liver transplantation

It is very uncertain whether intervention changes selective bowel decontamination versus inactive control compared with control (very low certainty).

2 findings from 1 review

Intervention vs control

Granulocyte‐colony stimulating factor (G‐CSF) versus placebo · people undergoing liver transplantation

It is very uncertain whether intervention changes granulocyte‐colony stimulating factor (G‐CSF) versus placebo compared with control (very low certainty).

2 findings from 1 review

Intervention vs control

Selective bowel decontamination versus prebiotics with probiotics · people undergoing liver transplantation
2 findings from 1 review

Intervention vs control

Selective bowel decontamination versus prebiotics · people undergoing liver transplantation
2 findings from 1 review

Intervention vs control

Prebiotics with probiotics versus prebiotics · people undergoing liver transplantation
2 findings from 1 review