Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,252 questions · 2,353 findings · 210 reviews · Neonatal

No studies found 432 · 18.4%GRADE not reported 99 · 4.2%Very low 609 · 25.9%Low 737 · 31.3%Moderate 385 · 16.4%High 91 · 3.9%

Early vs late continuous positive airway pressure (CPAP)

Pulmonary air leak defined as pneumothorax · preterm infants with respiratory distress for initial respiratory support

Early showed no clear difference in air leak (pneumothorax) compared with late continuous positive airway pressure (CPAP) (low certainty).

1 finding from 1 review

Early vs late continuous positive airway pressure (CPAP)

Bronchopulmonary dysplasia at 36 weeks' postmenstrual age · preterm infants with respiratory distress for initial respiratory support

It is very uncertain whether early changes bronchopulmonary dysplasia at 36 weeks' postmenstrual age compared with late continuous positive airway pressure (CPAP) (very low certainty).

1 finding from 1 review

Intervention not reported

Serum/plasma creatinine levels (μmol/L) after treatment Normal values for male and female newborns 17.7 to 88.4 µmol/L · preterm infants with patent ductus arteriosus

The intervention showed no clear difference in serum/plasma creatinine levels (μmol/L) after treatment Normal… (low certainty).

1 finding from 1 review

Intervention not reported

Failure to close a patent ductus arteriosus after 3 doses of ibuprofen · preterm infants with patent ductus arteriosus

The intervention probably leads to lower failure to close a patent ductus arteriosus after 3 doses of ibuprofen (moderate certainty).

1 finding from 1 review

Intervention not reported

Failure to close a patent ductus arteriosus (PDA) (after single or 3 doses) · preterm infants with patent ductus arteriosus

The intervention showed no clear difference in failure to close a patent ductus arteriosus (PDA) (after single or 3… (moderate certainty).

1 finding from 1 review